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Barbara Frosi

Publications and source records attributed to Barbara Frosi.

4 recordsLinked to original sources
PubMed2003

Lipid composition in atheromatous plaque: evaluation of the lipid three-phase percentage.

There is a renewed interest in the study of plaque lipid composition because it is recognized that it, rather than the luminal narrowing, influences the plaque stability and determines patient symptoms. At this purpose, we quantitatively evaluated in the carotid plaque of different categories of patients the expression of triglycerides, phospholipids, cholesterol, free cholesterol, esters of cholesterol, and the percentages of the three-phases (cholesterol, esters of cholesterol, phospholipids) by using the "Roozeboom triangle". Significant differences in the content of specific lipid and the percentage of the three-phases were detected among the different types of plaque evaluated in this study. The analysis of the three-phases by "Roozeboom triangle" may open a new approach in the study of atheromatous plaque and give new information on development of the disease.

Aged↗
PubMed2002

Purine nucleotide catabolism in rat liver: labelling of uric acid and allantoin after administration of various labelled precursors.

Uric acid and allantoin are the key compounds of purine nucleotide catabolism formed in liver and many other organs of the rat. We observed that, after administration of 14C-formate, incorporation of radioactivity into uric acid and allantoin is not similar, as one would expect. The phenomenon was demonstrated to be specific to liver and perfused liver, and not to other organs such as heart, jejunal mucosa, lung, spleen, and kidney. To interpret these results, the specific radioactivity of uric acid and allantoin in rat liver were analysed comparatively, after administration of the following labelled precursors: 14C-glycine, 14C-formate, 14C-hypoxanthine, 14C-uric acid and 14C-adenine. After administration of 14C-formate the specific radioactivity of allantoin was higher than that of uric acid and the same behavior was observed after 14C-uric acid and 14C-hypoxanthine, but not after 14C-glycine and 14C-adenine administration. The results indicate that the rate of their incorporation into uric acid and allantoin, and the subsequent export of these compounds into serum, can only partially explain the observed phenomenon, while the presence of different pools of uric acid and allantoin may give a complete explanation.

Adenine↗