[Notch1 receptor: structure and role during T-cell development].
The Notch family are proteins which function both as cell surface receptors and regulators of gene transcription. Notch proteins influence cell-fate decisions during lymphopoesis, neurogenesis and myogenesis. During lymphopoesis Notch1 is implicated in differentiation of lymphoid precursor CLP towards T-cells bot not B-cells lineage. In spite of earlier results suggesting involvement of Notch1 in commitment towards alpha beta and gamma delta or CD4 and CD8 T cell lineage, later experiments didn't confirm this possibility.
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