Barbara Macura | PubMed Health

PubMed2006

Lipopolysaccharide aggravates cerebral pathology in B10.PL-derived CD1-/-, beta2m-/-, TCRalpha-/-, and TCRdelta-/- knockout mice.

Adult B10.PL-derived immunological genes knockout mice injected with 100 microg lipopolysaccharide (LPS) showed severe hydrocephalus and meningitis. A consequence of the hydrocephalus is pineal hyperplasia, sponginess of periventricular parenchyma, gliosis and, at the last stage of hydrocephalus formation, disappearance of the ependymal layer and the Gomori-positive subependymal astrocytes. Possible mechanisms for the aggravation of cerebral pathology induced by LPS are discussed.

Animals↗

PubMed2004

[Phytoestrogens: are they really safe?].

The aim of this article was to present a simple classification of phytoestrogens, their approximate content in food products as well as their synthesis, biotransformation and activity in human organism. Having various mechanisms of action, phytoestrogens display both beneficial and adverse effects on physiological processes. Several positive health effects have been associated with phytoestrogens, such as a protective role against the development of cancers, proestrogenic effects (particularly with postmenopausal women) and beneficial influence on cardiovascular and osseous systems. Adverse effects of phytoestrogens have been observed in fetuses and young specimens. Limited studies have displayed disorders in morphology and physiology of the male reproductive system. High plasma phytoestrogens level inhibits a cellular activity of some enzymes, e.g. enzymes involved in the synthesis of steroid hormones. Direct contact with exogenous, environmental estrogens depends on human diet and it can be variable in different populations.

Cardiovascular Diseases↗