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Biomedical subjects

Barry Wilson

Publications and source records attributed to Barry Wilson.

6 recordsLinked to original sources
PubMed2006

Wave drag on human swimmers.

Drag measurements from a towed mannequin show total drag at the surface is up to 2.4 times the drag when fully immersed. This additional drag is due to the energy required to form waves in the wake behind the mannequin. The measurements show that passive wave drag is the largest drag, comprising up to 50-60% of the total at 1.7 m s(-1), much higher than any previous estimates. Comprehensive measurements spanning human swimming speeds and tow depths up to 1.0m demonstrate that wave drag on the mannequin is less than 5% of total drag for tows deeper than 0.5 m at 1 m s(-1) and 0.7 m at 2 m s(-1). Wave drag sharply increases above these depths to a maximum of up to 60% of the mannequin's 100 N total drag when towed at the surface at 1.7 m s(-1). The measurements show that to avoid significant wave drag during the underwater sections of starts and turns, swimmers must streamline at depths greater than 1.8 chest depths below the surface at Froude number (Fr)=0.2, and 2.8 chest depths at Fr=0.42. This corresponds to speeds of 0.9 and 2.0 m s(-1), respectively, for a chest depth of 0.25 m and toe to finger length of 2.34 m.

Computer Simulation↗
PubMed2005

Spectrophotometric determination of plasma and red blood cell cholinesterase activity of 53 fruit farm workers pre- and post-exposed chlorpyrifos for one fruit crop.

We sought to investigate the early biological effects of chlorpyrifos among 53 Thai fruit farm workers by measuring the plasma cholinesterase (PChE) and red blood cell cholinesterase (AChE) activities, a biomarker of organophosphate (OPs) pesticide during one fruit crop. The ChE activity (V(m)/K(m)) was spectrophotometrically analyzed before and after exposing to chlorpyrifos. The V(m)/K(m) values of both non-spraying and spraying seasons are found as normal distribution pattern. The median PChE and AChE activities among farm workers in the non-spraying season were 2.3 x 10(-3) s(-1) and 7.26 x 10(-5) s(-1), respectively. The median PChE and AChE activities of the farm workers in the spraying season were 2.02 x 10(-3) s(-1) and 5.95 x 10(-5) s(-1), respectively. The mean V(m)/K(m) values of PChE shifted left (t-test, p=0.013), indicating a decrease in PChE activity in the farm workers exposed to chlorpyrifos. However, the V(m)/K(m) values of AChE in nonspraying season and in the spraying season were not different (t-test, p=0.246). We propose that PChE activity can be used as a biomarker for monitoring early toxicity induced by chlorpyrifos insecticide.

Adolescent↗
PubMed2004

Differences in stroke phases, arm-leg coordination and velocity fluctuation due to event, gender and performance level in breaststroke.

The purpose of this study was to analyse stroke phases, arm-leg coordination and trunk motion fluctuation during breaststroke in elite male and female 50, 100 and 200 m events at the 9th FINA World Swimming Championships, Fukuoka 2001. Four phases of the arm stroke and three phases of the leg kick as well as phases of simultaneous arm and leg propulsion and recovery were identified from video of swimmers' motions below the surface. The duration of each phase was expressed as a proportion of the whole stroke cycle. Three measures of the arm-leg coordination, percent simultaneous arm-leg recovery time (%SRT), percent arm lag time (%ALT) and percent simultaneous arm-leg propulsion time (%SPT) were calculated. Mean mid-pool swimming hip velocity (V), stroke rate (SR) and stroke length (SL) were also calculated. In addition, the intra-cycle hip velocity of the swimmers was obtained by cinematographic analysis. The SR decreased and SL increased significantly as the event distance increased. For the arm-leg coordination the %ALT, %SPT and %SRT indicated significant differences between event, gender and performance level. In particular, for increasing event distance and for the higher performing swimmer the lower the %SPT and the higher the %SRT. In addition, the range of the intra-cycle hip velocity fluctuation in the lower performing group was greater than the higher performing group. The non-propulsive phase seems to be a key factor for better performance. The breaststroke swimmers must avoid rapid deceleration during the non-propulsive phase by adopting a low resistance posture and stroking technique.

Arm↗
PubMed2003

Drafting distance in swimming.

PURPOSE: This study investigates the effect of the distance separating the lead and draft swimmers on the metabolic and hydrodynamic responses of the draft swimmer. METHODS: A nondrafting swim of 4 min at 95% of the best 1500-m pace for 11 swimmers was compared with swimming in a drafting position at four different distances directly behind another swimmer (0, 50, 100, and 150 cm). Swimming performance was assessed by stroke rate and stroke length; the metabolic response by oxygen uptake, heart rate, and blood lactate; and the rating of perceived exertion by the Borg scale. Passive drag was assessed at these drafting distances by passive towing. Then, passive drag was measured in six swimmers towed in six lateral drafting positions, with swimmers separated by approximately 40 cm, and then measured in two positions at the rear of the lead swimmer with a reduced lateral distance between swimmers of 50 and 0 cm. RESULTS: Oxygen uptake, heart rate, blood lactate, rating of perceived exertion, and stroke rate were significantly reduced and stroke length was significantly increased in all drafting positions compared with the nondrafting position. For drag, the most advantageous drafting distances were 0 and 50 cm back from the toes of the lead swimmer. Drag was reduced by 21% and 20%, respectively. In lateral drafting, drag was significantly reduced by 6% and 7%, respectively, at 50 and 100 cm back from the hands of the lead swimmer. CONCLUSIONS: Swimming behind another swimmer at a distance between 0 and 50 cm back from the toes was the most advantageous, whereas in lateral drafting the optimal distance was 50-100 cm back from the hands of the lead swimmer.

Adult↗
PubMedDate not supplied

Formal heparin anticoagulation protocol improves safety of charcoal-based liver-assist treatments.

Extracorporeal devices have had limited effectiveness in liver failure due to consequences of inadequate anticoagulation. The purpose of this study was to evaluate an anticoagulation protocol developed for Liver Dialysis Unit (LDU) treatments. Twelve patients underwent 19 LDU treatments for acetaminophen overdose (n = 1), subacute liver failure (n = 1), and refractory encephalopathy in cirrhosis (n = 10). The initial 6 patients (group 1) were treated according to the manufacturer's recommendations. The subsequent 6 patients (group 2) were treated using a formal heparin anticoagulation protocol that included 2000 units in prime solution and 30 units/kg induction, activated clotting time (ACT) measurements, and heparin administered by dose-response curve to maintain 300-second ACT. Protamine reversal was used. Treatments were well tolerated and equally effective in both groups. Adequate (ACT > or = 250 seconds) and therapeutic (ACT 250-350 seconds) anticoagulation was maintained more consistently in group 2 (90.9% vs 50.0%, p < 0.0001; and 77.4% vs 45.8%, p < 0.001). There was less consumption of fibrinogen (12.1% vs 43.3%, p < 0.005) and platelets (13.8% vs 29.9%, p < 0.05) and a trend for less blood product used (8.3 vs 15.8 units/patient, p = 0.13) and fewer complications (16.7% vs 66.7%, p = 0.15) in group 2. Anticoagulation using ACT monitoring, heparin dose-response curves, and a target ACT of 300 seconds improves the safety of LDU treatments.

Acetaminophen↗