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Biomedical subjects

Barton H Hamilton

Publications and source records attributed to Barton H Hamilton.

10 recordsLinked to original sources

Evaluating individual surgeons based on total hospital costs: evidence for variation in both total costs and volatility of costs.

BACKGROUND: There is increasing interest in evaluating quality in health care, extending to the assessment of outcomes, including costs, for individual surgeons. STUDY DESIGN: Surgical patients entered in the private sector National Surgical Quality Improvement Program at the University of Michigan Medical Center between September 2003 and September 2004 were included. Patient level characteristics and outcomes measures were combined with internal hospital cost data. Analysis was performed at the individual surgeon level using hospital costs as the outcomes variable, controlling for patient case-mix variables and procedural complexity. We used an econometric statistical model combining ordinary least squares and quantile regression methods, which allowed us to examine the effect of individual surgeons on costs. RESULTS: Considerable variation in costs across surgeons is demonstrated, holding patient case mix and procedural complexity constant. This is shown for mean estimates (p<0.001) and estimates of 10th (p=0.001), 50th (p<0.001), and 90th (p=0.013) percentiles. Examining the 10th to 90th interquantile range also demonstrates substantial variation in the ranges of costs for surgeons (p=0.005), implying volatility in costs across providers, again holding patient case mix and procedural complexity constant. In dollar terms, 6 of 28 surgeons differ from a reference surgeon by 39% or more. CONCLUSIONS: Individual surgeons appear to have statistically and clinically significant differences in their costs and volatility of costs when holding patient factors and procedural complexity constant. Implications for quality improvement and incentive programs are discussed.

Costs and Cost Analysis↗

Impact of isolated clinical performance feedback on clinical productivity of an academic surgical faculty.

BACKGROUND: There is increasing financial pressure to maximize clinical productivity for academic physicians. We examined whether clinical performance feedback alone could contribute to improving the clinical productivity of surgeons in an academic department of surgery. STUDY DESIGN: We implemented a clinical performance feedback program in January 2003. We then compared clinical productivity in terms of relative value units (RVUs) of surgeons for 18 months before and 18 months after this intervention, using each surgeon as his or her own control. Regression was performed with dependent variable ln (monthly RVUs) and independent variables "calendar month," "pre/post" January 2003, and "surgeon." The coefficient on "pre/post" reflected average change in RVUs. We also surveyed faculty on their use of and attitudes toward this feedback. RESULTS: There was a 58% survey response. Ninety-two percent of responding faculty reported that they viewed and used the performance feedback, and that it affected their practice. Ninety-two percent believed the information accurately reflected their performance, 89% thought that the comparisons were useful, and 79% desired more feedback information, specifically, comparisons with external benchmarks. When RVU data were examined, the coefficient on change pre- and postintervention indicated a 7.4% increase in productivity (p < 0.001), or a 6.0% increase (p=0.003) after exclusion of outliers. CONCLUSIONS: Performance feedback was associated with a small (6.0%) but significant improvement in productivity in this academic surgical faculty group. Performance feedback can be useful and should be used in conjunction with other management tools for this population.

Academic Medical Centers↗

The assembly of organic radical anions between metal-borate scaffolds.

Metal-organic frameworks based on the Pb[B(Im)(4)](+) unit form layered structures analogous to those observed in clays and double layered hydroxide minerals. These layers can act as scaffolds for the organization of anionic organic guests. In this report, we use this scaffold to assemble TEMPO and PROXYL carboxylates in the interlayer spacings of Pb[B(Im)(4)](4-carboxy-TEMPO) 1 and Pb[B(Im)(4)](3-carboxy-PROXYL)(H(2)O)2, respectively. The resultant materials are paramagnetic, and the organization of the radical units differs between the two compounds. This results in changes in electronic structure of the radical unit, as observed by EPR spectroscopy.

Journal Article↗

Sequestering perrhenate with a borate-based coordination polymer: a model for pertechnetate separation.

Crystals of the layered metal organic framework solid Pb[B(Im)4](NO3)(nH2O) can undergo exchange of the nitrate for perrhenate, a model for pertechnetate, forming Pb[B(Im)4](ReO4). We can monitor this reaction by 207Pb solid-state NMR and can isolate single crystals of the resultant material through growth in the presence of an excess of perrhenate. Such a synthetic metal-organic framework solid represents a new candidate for pertechnetate-sequestering materials.

Journal Article↗

Lead and thallium tetrakis(imidazolyl)borates: modifying structure by varying metal and anion.

We are using the coordinating anions tetrakis(imidazolyl)borate and tetrakis(4-methylimidazolyl)borate to construct new metal-organic framework structures. In this report, we are exploring materials similar in composition to the previously reported layered network structure Pb[B(Im)(4)](NO(3))(nH(2)O). The metal in this compound can be replaced with isoelectronic Tl(I), affording Tl[B(Im)(4)], and the borate can be modified by using 4-methylimidazole, resulting in Pb[B(4-MeIm)(4)](NO(3)) and Tl[B(4-MeIm)(4)]. Like the parent Pb[B(Im)(4)](NO(3))(nH(2)O), Tl[B(Im)(4)] and Tl[B(4-MeIm)(4)] are layered network structures but both lack anions or solvent molecules in the interlayer spacing. The material Pb[B(4-MeIm)(4)](NO(3)), however, exhibits a 3D network structure that lacks an open topology, resulting from the increased stereochemical activity (greater steric bulk toward other ligands) of the 4-methylimidazole ring. Both of the Tl(I) solids display longer M-N bonds than observed in the analogous Pb(II) compounds; these lengths account for the decreased effect of the stereochemical activity of the 4-methylimidazole ring in Tl[B(4-MeIm)(4)].

Journal Article↗

Lead tetrakis(imidazolyl)borate solids: anion exchange, solvent intercalation, and self assembly of an organic anion.

The coordination polymer Pb[B(Im)(4)](NO(3))(xH(2)O), constructed by using sodium tetrakis(imidazolyl)borate and lead(II) nitrate solutions, is a layered material with the metal centers facing the interlayer spacing. As in naturally occurring layered minerals, this compound can readily undergo anion exchange and reversible intercalation of solvent water in the solid state with retention of crystallinity. We observed changes in solvent intercalation by (207)Pb solid state NMR (SSNMR) and thermogravimetric analysis (TGA). Stoichiometric exchange of (15)N nitrate for nitrate and iodide for nitrate is monitored by (15)N and (207)Pb SSNMR, and single crystals of the iodide-exchanged material Pb[B(Im)(4)]I were isolated. While the iodide compound can be obtained through facile exchange from the nitrate parent compound, the organic anion benzoate is placed in the interlayer spacing for nitrate under self-assembly conditions and forms an alternating monolayer in Pb[B(Im)(4)](C(6)H(5)COO)(0.5H(2)O). The ion exchange versus self-assembly behavior correlates with the structural differences in the three compounds. In both Pb[B(Im)(4)]I and Pb[B(Im)(4)](C(6)H(5)COO)(0.5H(2)O), the lead sites act as Lewis acids for the iodide and benzoate, respectively.

Journal Article↗

Tetrakis(imidazolyl)borate-based coordination polymers: group II network solids, M[B(Im)4]2(H2O)2 (M = Mg, Ca, Sr).

We are using the coordinating anion tetrakis(imidazolyl)borate to construct new metal-organic framework structures. In this report, we present three alkaline earth metal network solids incorporating this anion. All three compounds have the same formula, M[B(Im)(4)](2)(H(2)O)(2) (M = Mg, Ca, Sr), and the same coordination environment about the metal. However, the three compounds have different network structures with different degrees of hydrogen bonding; the Mg material forms a two-dimensional network and the Ca and Sr compounds form one-dimensional chains. In addition, we present the structure of the protonated anion B(HIm)(Im)(3) as a model for the default structure of this anion and discuss how the conformation of tetrakis(imidazolyl)borate can affect the structure of network solids.

Journal Article↗

Construction of a functional layered solid using the tetrakis(imidazolyl)borate coordinating anion.

The coordination polymer Pb[B(Im)(4)](NO(3)), constructed by using tetrakis(imidazolyl)borate and lead(II) nitrate solutions, is a layered material with the metal centers facing the interlayer spacing. As in naturally occurring layered minerals, this compound can readily undergo anion exchange in the solid state with retention of crystallinity. We examined stoichiometric exchange of (15)N-nitrate for nitrate and iodide for nitrate by (15)N and (207)Pb SSNMR and confirmed retention of crystallinity by IR and powder XRD diffraction.

Journal Article↗

Impact of resident duty-hour reform on faculty clinical productivity.

OBJECTIVE: Prior data have shown that resident duty-hour reform has not affected faculty work hours; yet the preservation of faculty hours may have been at the expense of productivity. We sought to examine change in clinical productivity. DESIGN: Anonymous survey and analysis of faculty relative value units (RVU) database. SETTING: A single, large academic medical center. PARTICIPANTS: All clinical faculty in the Department of Surgery. METHODS: An anonymous survey was distributed to surgical faculty 18 months after reform and compared with surveys taken before and after reform. Opinions regarding productivity and working hours were solicited. P values were determined by chi-square or Student t-tests. Relative value unit data, reflecting clinical productivity, were compared before and after reform. Regression was performed with dependent variable "lnRVU" and independent variables "calendar month," "pre/post" July 2003, and "surgeon." The coefficient on "pre/post" reflected average change in RVUs. RESULTS: A total of 49 of 73 surveys were returned (67% response). Faculty reported an average of 68.0+/-7.0 weekly work hours (p=NS compared with previous survey). In the current survey, 35% felt their overall productivity had fallen due to reform. Among these, 83% felt academic productivity had suffered, 11% were unsure, and 1 person (6%) believed academic productivity was preserved. The majority (82%) reported preserved clinical productivity, 6% reported a decrease, and 12% were unsure. Overall, 60% reported doing work previously done by residents. When RVU data were examined, the coefficient on change pre- and post-reform indicated a 5.7% increase in productivity (p=0.005). However, this effect was driven by 5 surgeons with a greater than 75% increase in productivity, all young faculty, early in practice. Excluding these, there was no significant change (0.6% increase, p=0.77). CONCLUSIONS: Faculty have preserved work hours and clinical productivity, despite a tendency to take on work previously done by residents. This suggests that academic activities may have suffered.

Academic Medical Centers↗