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Beata Urban

Publications and source records attributed to Beata Urban.

16 recordsLinked to original sources
PubMed2006

[Correlation analysis between diabetic retinopathy and early atherosclerotic changes in adolescents with type 1 diabetes -- preliminary report].

OBJECTIVE: Recent studies have shown a correlation between advanced diabetic retinopathy and late stages of atherosclerosis. There are no findings on a possible relation between diabetic retinopathy and diseases of the cardiovascular system at their earliest stage in young people with diabetes type 1. The purpose of the study was to analyze a correlation between diabetic retinopathy and early atherosclerotic changes in adolescents with type 1 diabetes. RESEARCH DESIGN AND METHODS: The study included 28 adolescents aged 17.6+/-1.4 years suffering from type 1 diabetes mellitus for 7.9+/-3.1 years, the mean age of the disease onset - 9.5+/-3.7 years, a mean level of HbA1c - 8.6+/-1.9%. Eight patients with developing simple retinopathy, were separated from the whole group of young people. First control group consisted of the remaining patients with type 1 diabetes chosen with regard to age and sex, without disease complications. Second control group consisted of 11 healthy young people. The function of endothelium by measuring the brachial artery dilatation -- FMD and the intima-media complex thickness of the common carotid arteries were evaluated ultrasonographically. RESULTS: Young people with retinopathy had higher systolic pressure: 133+/-19 mmHg in comparison with patients without complications: 117+/-14 mmHg (p<0.05) and healthy people: 115+/-8 mmHg (p<0.05). All patients with diabetes showed significantly lower FMD (7.6+/-5.1%, p<0.05). In the group with retinopathy, FMD equaled 7.8+/-4.1% (p=0.04) and in the group without retinopathy - 7.6+/-5.5% (p<0.05) in comparison with 12.1+/-5.1% in healthy volunteers. Significantly higher IMT was found in all patients with diabetes in comparison with healthy young people: 0.49+/-0.06 vs. 0.42+/-0.03 mm (p<0.001). Patients with retinopathy had a significantly higher value of IMT in comparison not only with controls but also with patients without complications: 0.56+/-0.06 vs. 0.47+/-0.03 mm (p<0.001). CONCLUSIONS: 1. Young people with type 1 diabetes had a significantly impaired function of endothelium and higher IMT in comparison with healthy young people. 2. Adolescents with retinopathy were characterized by significantly higher values of systolic arterial blood pressure when compared to patients without complications 3. Higher IMT was found in patients with diabetic retinopathy in comparison with patients without complications, which may suggest that macrovascular changes are more advanced in case of complications than in patients without retinopathy.

Adolescent↗
PubMed2006

[The assessment of 24-hour ambulatory blood pressure monitoring (ABPM), microalbuminuria and diabetic autonomous neuropathy in children with type 1 diabetes and hypertension].

INTRODUCTION: The late complications of diabetes consisted of autonomic neuropathy, nephropathy, which more often coexist with hypertension in children with type 1 diabetes mellitus. THE AIM OF THE STUDY was to assess the connections between changes in the autonomous nervous system, 24-hour ABPM and daily albumin excrection in children with hypertension and type 1 diabetes mellitus. MATERIAL: The group consisted of 72 patients with diabetes (diabetes duration time 6.5+/-1.5 years). 34 patients of that group have hypertension. The control group consisted of 30 healthy children matched according to age and sex. RESULTS: In children with hypertension we found significantly often occurrence of microalbuminuria (13/34 i 1/38, p<0.001). In 17 patients from the group with hypertension and 17 patients without hypertension we affirm signs of autonomic neuropathy. The values of heart rate variability (HRV) were significantly decreased in the group with hypertension as compared to the control group. A stepwise multiple regression analysis with hypertension as a dependent variable and diabetes duration time, microalbuminuria, HbA1c level, HRV parameters and a presence of autonomous neuropathy as predictors proved that hypertension is associated with higher HbA1c level (b=0.35), the presence of autonomous neuropathy (b=0.28), and lower HF values (b=0.41) (p<0.01). CONCLUSIONS: Hypertension in children with type 1 diabetes mellitus is correlated with the presence of autonomous neuropathy, higher HbA1c level and lowered values of heart rate variability parameters.

Adolescent↗
PubMed2005

[Effect of human growth hormone treatment on the eyes of patients with somatotropic pituitary insufficiency and in girls with Turner's syndrome].

INTRODUCTION: The increased use of human growth hormone (hGH) in numbers of children rise questions concerning the safety of GH replacement therapy (GHRT). Adverse effects of hGH treatment (pseudotumor cerebri, papilloedema, retinal changes mimicking diabetic retinopathy, neovascularization) have been reported in some papers. PURPOSE: The aim of this study was to evaluate the influence of hGH therapy on the organ of vision. MATERIAL AND METHODS: 10 girls with Turner's syndrome aged 12-16 years (mean 13.8+/-1.69) and 20 patients with somatotropic pituitary insufficiency aged 7-18 years (mean 12.98+/-2.81) were studied. The mean duration of GHRT in patients with Turner's syndrome was 3.05+/-1.42 years (from 1 year to 5 year), in patients with somatotropic pituitary insufficiency was 2.45+/-2.32 years (from 8 months to 10 years). All patients underwent ophthalmic examination, including contrast sensitivity, direct and indirect ophthalmoscopy and fluorescein angiography. RESULTS: All parts of ophthalmological examination were normal. There were no abnormalities in fluorescein angiography. Contrast sensitivity was correct in all eyes. CONCLUSIONS: There was no harmful effect of GHRT on the retina and optic nerve in young patients. The follow-up and ophthalmologic evaluation is advisable.

Adolescent↗
PubMed2005

[Evaluation of corneal endothelium after pediatric cataract surgery in children and adolescents].

PURPOSE: to evaluate the effects of cataract extraction and lens implantation on corneal endothelium morphology. MATERIAL AND METHODS: In 21 eyes of 14 children with congenital or developmental cataract, corneal endothelium was studied. Patient age was 9 to 19 years (mean 12.9 years). In all eyes extracapsular cataract extraction (ECCE) with PMMA intraocular lens implantation was performed, without primary posterior capsulotomy or anterior vitrectomy. Lens wearers, patients with traumatic cataract or external eye diseases and ocular surgery in history were excluded. The endothelium was imaged by non-contact microscope Topcon SP-2000P. This examination was done preoperatively and 1 month, 6 months and 1 year postoperatively. Corneal thickness (T), corneal endothelial density (ECD) and mean cell area (AVG) of endothelial cells were examined. RESULTS: Mean corneal thickness was 0.55 mm after 1 month, 0.54 mm after 6 months and 0.54 mm after 12 months. The mean preoperative endothelial cell density was 3231.1 cells/mm2. ECD after 1.6 and 12 months was 2874.3; 2639.2 and 2479.9 cells/mm2 respectively. Mean endothelial cell loss was 10.94% after 1 month, 17.85% after 6 months and 22.68% after 12 months. AVG before operation was 315.8 mm2, after 1 month 355.8 mm2, after 6 months 382.4 mm2 and 399.5 mm2 after 12 months. CONCLUSIONS: Changes in corneal endothelium morphology had no effect on transparency of the cornea.

Adolescent↗
PubMed2005

[Progression of diabetic retinopathy in patient with Graves' disease].

The authors present the case of 16-year old girl with diabetes mellitus type 1. She had progression of diabetic retinopathy because of occurrence of Graves' disease. Surgical intervention (strumectomy subtotal, bilateral), was performed and regression of retinal changes was observed.

Adult↗
PubMed2004

[Assessment of growth factor levels in adolescents with type 1 diabetes mellitus and the beginning of diabetic microangiopathy].

OBJECTIVE: The purpose of the study was the evaluation of growth hormone (GH), insulin-like growth factor (IGF-1), insulin-like growth factor binding protein (IGFBP-3) and vascular endothelial growth factor (VEGF) in adolescents with type 1 diabetes as well as the relationship between the concentration of examined proteins and the early development of diabetic microangiopathy. RESEARCH DESIGN AND METHODS: The study included 68 patients aged 15.54+/-2.9 years with type 1 diabetes. They were divided into groups: I - adolescents with the beginning of vascular complications, II - without complications. Controls consisted of healthy adolescents. GH, IGF-1, IGFBP-3 and VEGF were determined with use of ready kits. RESULTS: The increased levels of GH were found in diabetic adolescents in comparison with controls (10.11+/-16.21 vs. 2.89+/-4.03 micro IU/ml, p<0.05). The levels of IGF 1 were lower in adolescents with type 1 diabetes than in controls (283.48+/-117.36 vs. 427.95+/-177.48 ng/ml, p<0.05), as well as the levels of IGFBP-3 (5555.21+/-1158 vs. 6622.18+/-1110 pg/ml, p<0.05). Significantly higher concentration of VEGF was revealed in diabetic adolescents in comparison with controls (328.68+/-251 vs. 132.19+/-85 pg/ml, p<0.05). The highest levels of VEGF were reported in diabetic patients with retinopathy in comparison with patients without complications. CONCLUSIONS: The impaired activity of GH-IGF-1-IGFBP-3 axis may be responsible for the development of diabetic microangiopathy. The evaluation of VEGF concentration can be a sensitive early marker of microangiopathy.

Adolescent↗
PubMed2004

[The effectiveness of latanoprost for the treatment of pediatric glaucoma].

Latanoprost is a prostaglandin F2alpha analog that reduces intraocular pressure by 20-40% in adults with open-angle glaucoma. The efficacy and safety of this drug in children has not been widely reported. In our study we evaluated the effect of latanoprost in 14 children aged 12-18 years (mean 15 years): 10 patients with glaucoma juvenile (I group); 2 patients with secondary glaucoma because of uveitis recidivans and 2 patients with aniridia and albinismus (II group). In the I group the average IOP decrement was 9 mmHg or 36.5% (range 29-44%). In the II group the average IOP decrement was 6.5 mmHg or 23.5% (range 11-33%). In one child with aniridia after one year of treatment IOL rose again to 26 mmHg and antiglaucomatous surgery was necessary. Ocular side effects in children of latanoprost are mild.

Adolescent↗
PubMed2004

[Effect of pentoxifylline on Doppler blood flow parameters in the central retinal artery and the short posterior ciliary arteries in adolescents with progressive myopia].

PURPOSE: To evaluate the effect of pentoxifylline on blood flow in the central retinal artery and the short posterior ciliary arteries in patients with progressive myopia. MATERIAL AND METHODS: 48 eyes of 24 healthy patients aged between 12 and 18 years (mean 15.1 years) with myopia from -5.0 to -12.75 Dsph (mean -7.56 Dsph), were examined using color Doppler ultrasonography. The examination was performed before and after 10 days of intravenous administration of 200 mg of pentoxifylline. The peak-systolic, end-diastolic flow velocities, pulsatility, resistance and systolic/diastolic ratios were measured. RESULTS: The use of pentoxifylline significantly increased PSV and EDV in the central retinal artery and in the short posterior ciliary arteries (p=0.0001) in patients with progressive myopia and in the same time decreased PI, RI and S/D (p=0.0001). There was no correlation between Doppler blood flow parameters and dioptres or axial length. CONCLUSIONS: pentoxifylline increases retinal and choroidal blood flow in young patients with progressive myopia.

Adolescent↗
PubMed2004

[Evaluation of the vascular endothelial growth factor in children and adolescents with type 1 diabetes].

UNLABELLED: Diabetes type 1 is the chronic disease, leading to many acute and late complications. Pathogenesis of the late complications is not fully understood. Lately, growth factors, and especially vascular endothelial growth factor (VEGF) are gaining great interest as potential risk factors of late diabetic complications, mainly nephropathy and retinopathy The aim of the study was evaluation of the level of VEGF in children and adolescents with diabetes type 1, and searching for correlation between level of this cytokine and microangiopathy and metabolic control. MATERIAL AND METHODS: 68 young diabetic type patients were studied, aged 8-20 yrs (x = 15.54 yrs), suffering from diabetes type 1 from 2.3-16.5 yrs (x = 7.84 yrs), 34 boys, 34 girls. They were all under control of Outpatient Diabetic Department. Control group were healthy children, age and gender matched. Metabolic control was assessed on the basis of HbA1c level. All children underwent ophthalmology examination, microalbuminuria was evaluated in 24 hours urine samples. VEGF was estimated with use of immunoenzymatic method (RD Systems). RESULTS: In the study group we found: significantly higher levels of VEGF compared to control group (328.68 +/- 251.6 vs 132.19 +/- 85.51 pg/ml: p<0.05). We did not find any differences between genders in VEGF level. VEGF increases with diabetes duration time, and the highest values are in children with diabetes duration over 10 years, although the differences did not reach statistical significance. VEGF level was significantly higher in children with poor metabolic control of the disease (406.65 +/- 322.11 pg/ml vs 132.19 +/- 85.51 pg/ml; p<0.05). Patients with retinopathy had the highest level of VEGF, compared to children without complications. CONCLUSIONS: Assessment of VEGF level can be useful method in prognosis of diabetes microangiopathic complications. As microalbuminuria occurs relatively late in diabetic complications process, evaluation of VEGF may become a prognostic marker of the earliest phases of this complication.

Adolescent↗
PubMed2004

[MCA/MR anomaly--case report].

PURPOSE: MCA/MR (Cohen syndrome) is a multiple congenital anomalies retardation syndrome with autosomal recessive inheritance. The clinical criteria are nonspecific. The diagnosis was based on the triad: hypotonia, truncal obesity and prominent central incisors. Added to the clinical spectrum ophthalmologic findings such as antymongoloid eye slant and retinal changes, are very important to diagnosis. MATERIAL AND METHOD: The authors present a case of 11-year-old boy with MCA/MR. RESULTS: In this patient we found decreased visual acuity, myopia and retinal abnormalities. CONCLUSIONS: Cohen syndrome is a congenital anomaly with general and ophthalmological findings.

Abnormalities, Multiple↗
PubMed2003

[Growth hormone, insulin-like growth factor and insulin-like growth factor binding protein in young type I diabetes patients with the onset of diabetic angiopathy].

UNLABELLED: Growth hormone, insulin-like growth factors and their binding proteins are now gaining a great interest in the development of microvascular complications in diabetic children and adolescents. THE AIM OF THE STUDY WAS: 1. Evaluation of growth hormone (GH), insulin-like growth factor (IGF-1) and insulin-like growth factor binding protein (IGFBP-3) levels in youths with diabetes type 1. 2. Evaluation of correlations between this proteins and the development of microvascular complications and metabolic control. MATERIAL AND METHODS: The study was carried out on 39 young diabetic persons aged (8-20 yrs), mean-14.8, suffering from diabetes mean 7.45 yrs (2.3-15), 20 boys and 19 girls, diabetic outpatient clinic patients. The study group was divided into 2 groups: I, n = 11, with the begin of microangiopathy and group II, n = 28, without any symptoms of vascular complications. Control group consisted of 16 healthy adolescents. GH, IGF-1 and IGFBP-3 levels were estimated by use of radioimmunoenzymatic methods. RESULTS: In adolescents with diabetes we found higher GH levels, and lower IGF-1 as well as IGFBP-3 levels in comparison to control group. Statistically higher were IGF-1 and IGFBP-3 levels in children with diabetes duration longer than 10 years. Metabolic control did not influence GH, IGF-1 or IGFBP-3 levels. CONCLUSIONS: 1. Children and adolescents with diabetes type 1 have elevated level of growth hormone, with lower level of IGF-1 and IGFBP-3. 2. Oversecretion of growth hormone did not depend on metabolic control. 3. Adolescents with diabetic microangiopathy have significantly elevated levels of growth hormone and low levels of IGFBP-3. 4. Disturbances in axis GH-IGF-1--IGFBP-3 seems to be responsible for early development of diabetic microangiopathy. This knowledge may give new opportunities for therapy diabetic children and adolescents with early phases of microangiopathy with recombinated IGF-1.

Adolescent↗
PubMed2003

[The role of vascular endothelial growth factor (VEGF)].

The authors present the role of VEGF in microaneurysm formation, blood-retinal barrier breakdown, development of capillary nonperfusion and retinal neovascularization in pathogenesis of diabetic retinopathy. Inhibitors of VEGF in treatment of diabetic retinopathy are presented.

Aneurysm↗
PubMed2003

[The surgical results of correcting strabismus with inferior oblique hyperfunction].

PURPOSE: To evaluate the surgical results of correcting strabismus with inferior oblique hyperfunction. MATERIAL AND METHODS: A retrospective chart review of 40 patients, who underwent surgery from 1999-2001 was performed. 7 patients had isolated inferior oblique hyperfunction, 5 with hypertropia, 23 patients had esotropia with inferior oblique hyperfunction and 5 patients had exotropia with inferior oblique hyperfunction. The recession of inferior oblique muscle was undergone in cases with inferior oblique hyperfunction, sometimes in hypertropia with anteposito. The recession-resection of rectus muscles with myotomy-tenotomy of inferior oblique muscle or his recession usually were performed in cases with coexisting esotropia or exotropia. RESULTS: In all cases eyes were acceptably aligned. The recession of inferior oblique muscle is the most effective method of operation in high oblique hyperfunction.

Child↗
PubMed2002

[Corneal endothelium in children and adolescents with myopia].

PURPOSE: To determine, whether the myopia could has an influence on corneal endothelium morphology. MATERIAL AND METHODS: Patients' age was from 13-th to 18-th years. Lens wearers and patients with external eye diseases and ocular surgery in the history, were excluded. The endothelium was imaged by non-contact microscope Topcon SP-2000P. The following parameters were examined: corneal thickness, corneal endothelial density, mean cell area of endothelial cells, coefficient of variation of cell size. RESULTS: There were no significant differences in the corneal thickness among various degrees of myopic refractive error. Endothelial cell density (ECD) decreased in eyes with high myopia, but it not correlated either with corneal thickness nor with axial length of eyes. There was correlation between average cell area (AVG) and the degree of myopia.

Adolescent↗