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Biomedical subjects

Bedri Seven

Publications and source records attributed to Bedri Seven.

12 recordsLinked to original sources
PubMed2007

Evaluation of the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients by rhinoscintigraphy.

OBJECTIVE: The purpose of this study was to assess the effect of levocetirizine on nasal mucociliary clearance in allergic rhinitis patients using rhinoscintigraphy. METHODS: Twenty patients with allergic rhinitis (12 males and eight females, mean age 37.7 +/- 10.5 years) were evaluated. All the patients received levocetirizine (5 mg x day(-1)) for 4 weeks, and the speed of nasal mucociliary clearance was assessed before and after treatment. Twenty healthy controls (11 males and nine females, mean age 39.4 +/- 7.8 years) were also evaluated. RESULTS: The clearance values obtained for the treated group before and after treatment were significantly lower than those of the control group (P = 0.0001), but there was no significant difference in clearance speeds before and after treatment in the patient group (P = 0.444). CONCLUSION: The study demonstrated that levocetirizine did not affect the speed of nasal mucociliary clearance in allergic rhinitis patients, and that nasal mucociliary clearance can easily be evaluated by rhinoscintigraphy.

Adult↗
PubMed2006

Comparison of extraarticular leakage values of radiopharmaceuticals used for radionuclide synovectomy.

OBJECTIVES: Radionuclide synovectomy is a reliable therapy in patients with chronic synovitis. However, radiation doses delivered to non-target organ systems due to leakage of radioactive material from the articular cavity are an important disadvantage of this procedure. In this study we compared extraarticular leakage values of the 3 commonly used radiopharmaceuticals; 90Y-citrate, 90Y-silicate and 186Re-sulfide colloid. MATERIALS AND METHODS: Thirty-five patients with persistent synovitis were enrolled in the study. Twenty-two hemophilic, 8 rheumatoid arthritis and 5 patients with pigmented villonodular synovitis were studied. 90Y labeled silicate and citrate were used for knee joints and 186Re-sulfide for intermediate sized joints. Radiocolloid leakage values were evaluated using a gamma camera with 20% window centered over the bremsstrahlung photopeak of 90Y and a respective window over the 137 keV photopeak of 186Re. Regions of interest were drawn over the injection site, the regional lymph nodes and the background areas. Leakage of radiocolloid was calculated by dividing the counts/pixel in the regional lymph node area to the counts/pixel in the injection site. RESULTS: No visible leakage was observed. The median leakage values calculated for 90Y-citrate, 90Y-silicate and 186Re-sulfide were found as 1.9%, 2.4% and 2.7%, respectively. The difference between the variability of leakage values was not statistically significant (p > 0.05). CONCLUSION: There was no significant difference in terms of extraarticular leakage between 9Y-citrate, 9Y-silicate and 186Re-sulfide radiocolloids.

Adolescent↗
PubMed2006

Morphological asymmetry in thyroid lobes, and sex and handedness differences in healthy young subjects.

The aim of the present study was to investigate sex and handedness differences in the sizes of the right and left thyroid lobes. Subjects were 72 healthy university students (36 female and 36 male), 18 to 23 years of age. Hand preference was assessed using the Edinburgh Handedness Inventory. The volumes of the right and left thyroid lobes were measured by ultrasonography. The right lobe was larger than the left. The right and left lobes were larger in men than in women. There were no handedness difference in the total thyroid volume and the volume of right lobe. But, the left lobe was larger in right-handed subjects than in the left handed ones. The difference (right minus left) was statistically larger in left-handers than in right-handers. The sex-related differences may be attributed to the sex differences in body weight. It can be stated that handedness is associated with the asymmetry of thyroid lobes.

Adolescent↗
PubMed2006

99mTc-labelled red blood cell single-photon emission computed tomography for the diagnosis and follow-up of juvenile nasopharyngeal angiofibroma.

AIM: To confirm the usefulness of blood pool scintigraphy with Tc-labelled red blood cells ((99m)Tc-RBCs) in the diagnosis and follow-up of juvenile nasopharyngeal angiofibroma. METHODS: A prospective study design was used. (99m)Tc-RBCs were prepared by a modified in-vivo method. After the rapid intravenous injection of 370-740 MBq of (99m)Tc-RBCs, dynamic imaging of 1-min duration was performed. After dynamic imaging, static acquisitions at 5 min (second phase: blood pool phase) and 2 h (third phase: static image) were obtained. In addition, single-photon emission computed tomography (SPECT) imaging was performed at 2 h. SPECT images were obtained using a rotating gamma camera (GE-Starcam 4000 XR/T). RESULTS: All patients showed no activity in the first phase and mild activity in the second phase (blood pool phase). All patients with juvenile nasopharyngeal angiofibroma showed a prominent increased activity in the third phase and in SPECT images. CONCLUSIONS: This study shows that blood pool scintigraphy with (99m)Tc-RBC SPECT is very accurate, easy to perform and a suitable alternative to pre-operative and post-operative imaging techniques, including computed tomography scan, magnetic resonance imaging (MRI) and MRI angiography, for the detection of juvenile nasopharyngeal angiofibroma.

Adolescent↗
PubMed2006

The evaluation of myocardial damage in 83 young adults with carbon monoxide poisoning in the East Anatolia region in Turkey.

Carbon monoxide (CO) poisoning is the leading cause of death from intoxication. In CO poisoning, it is important to know if there are any symptoms regarding myocardial damage, which are usually unobserved as a result of hypoxia. This study was planned to assess myocardial damage in young healthy patients with CO poisoning. Eighty-three young healthy cases who had been exposed to CO were included in this study. The demographic and clinical characteristics, the origin of CO gas and smoking habits of the patients were recorded. The evaluation of ECG, peripheral ABG, complete blood count and serial cardiac biomarkers (creatine kinase, creatine kinase-myocardial band and troponin I) measurements were performed in all cases. Additionally, echocardiogram (ECHO) and myocardial perfusion single-photon emission computed tomography (SPECT) were performed at the appropriate times in all cases. The mean age of the patients was 27.3 +/- 10.9 years. The main complaint of the patients was loss of consciousness with a 62.7% rate. The average carboxyhaemoglobin level of the patients was 34.4 +/- 15.9%. Sinus tachycardia was present in 26.5% of patients. Diagnostic ischaemic ECG changes were present in 14.4% of patients. In myocardial SPECT, myocardial ischaemic damage was observed in 9 cases, in 6 of whom ECHO findings were also confirmed. Myocardial damage due to CO poisoning should not be ignored. If patients are at risk in terms of myocardial damage, further studies, such as ECHO and scintigraphy are needed to determine myocardial damage resulting from CO poisoning. However, in the young adults of the risk group, if the baseline ECG and serial cardiac biomarkers are normal, further studies such as ECHO and scintigraphy, considering the length of exposure and the severity of poisoning, may not be necessary for the evaluation of myocardial damage due to CO poisoning.

Adolescent↗
PubMed2005

Evaluation of the anti-inflammatory effect of erythromycin on aseptic inflammation of temporomandibular joint in rabbit: a scintigraphic and histopathologic study.

This article investigates the anti-inflammatory effects of erythromycin (EM) on aseptic inflammation of temporomandibular joint (TMJ) space using by Tc-99 m HIG scintigraphy and histopathology. In this experimental study, 33 adult male New Zealand White rabbits were divided into three groups. The animals in the first group were treated with EM 25 mg kg(-1); the animals in the second group were treated with methylprednisolone (MP) 2 mg kg(-1) and the animals in the third group were given saline solution (control group). Each drug was given by intraperitoneal injection twice a day for 7 days. Two hours after the last injection, carrageenan was injected into right TMJ of rabbits for aseptic inflammation. After carrageenan injection, each rabbit was given an intravenous injection of 111 Mbq (3 mCi) Tc-99 m human HIG, and scanning was performed 4 h later. Later, all animals were killed and TMJ and periarticular tissues were resected. Histopathologically, the distance between synovial surface epithelium (SSE) and muscle layer (ML) in each section was measured by using SAMBA 200 Cell image processor with software. Scintigraphically, when lesion activity/adjacent region activity (L/N) was evaluated there was a significant difference between the control group and the other two groups (P < 0.05 for EM and MP). However, no significant difference was found between the EM and MP groups. Histopathologically, the mean distance between SSE and ML in the sections was found longer in the control group (78.6 +/- 10.7 microm) than in the EM (44.38 +/- 18.26 microm) and MP (44.05. +/- 18.25 microm) groups. We think that administration of EM, which is a well-known macrolid antibiotic, might be very effective in the treatment of aseptic inflammation of TMJ space. Because corticosteroid administration has many side effects, EM may be a preferable drug in the treatment of inflammation of TMJ.

Animals↗
PubMed2005

Genotoxicity of thallium-201 in patients with angina pectoris undergoing myocardial perfusion study.

Thallium-201 (201Tl) has been widely used as a nuclear reagent for myocardial blood flow imaging. The purpose of this study was to investigate genotoxic effects of 201Tl in patients with angina pectoris (n = 21), who had undergone myocardial perfusion imaging. Lymphocytes were isolated from each patient before, and 3, 30 and 90 days after 201Tl administration (111 MBq, 3 mCi) and were analyzed for chromosomal aberrations, sister chromatid exchanges, mitotic index and replicative index. There were significant increases in chromosomal aberrations and sister chromatid exchanges 3 days after 201Tl administration (p < 0.001), although no difference was noted in these values after 30 and 90 days (p > 0.05). Moreover, decreased mitotic index and replicative index were noted after 3 days of 201Tl administration (p < 0.001). These results suggest that the administration of 201Tl for myocardial blood flow imaging may induce genetic damage.

Angina Pectoris↗
PubMed2004

Handedness and bilateral femoral bone densities in men and women.

To examine the relation of hand preference to bilateral femoral bone mineral density (BMD), the right and left total and regional (neck, trochanter, intertrochanteric, and Ward's triangle) proximal femur BMDs (g/cm2) were measured using dual-energy X-ray absorbtiometry (DEXA) in 32 right- and 26 left-handed university students. The mean total BMD of the total right-handers and the mean trochanteric BMD of the right- handed males were greater in the left femur than the right femur. Contrarily, the total left-handers had higher mean intertrochanteric BMD in the right side than in the left side. There were negative correlations between R-L BMD differences and Geschwind scores of total, male, and female subjects. The results suggest that femur-BMD may be related to hand preference.

Absorptiometry, Photon↗