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Biomedical subjects

Benjamin H Ticho

Publications and source records attributed to Benjamin H Ticho.

4 recordsLinked to original sources

Combined strabismus and lens surgery.

BACKGROUND: Simultaneous eye muscle and lens surgery in patients with strabismus and lens abnormalities offers the advantage of avoiding staged surgery. METHODS: Thirty-three combined strabismus and lens surgeries were performed on 30 patients who ranged in age from 22 months to 91 years. Fifteen of the strabismus procedures were performed for esotropia, 12 for exotropia, 4 for vertical deviations, and 2 for combined vertical-horizontal deviations. Surgical amounts often were reduced to lessen the risk of overcorrection, to minimize anesthetic requirements (when using topical rather than general anesthesia), or to avoiding additional surgery on the contralateral or ipsilateral eye. The intraocular surgeries included cataract extraction without or with posterior chamber intraocular lens, secondary intraocular lens implantation, and YAG laser posterior capsulotomy. In 28 cases, muscle and intraocular surgery was performed on the same eye, and in 5 cases the strabismus surgery was performed on the eye opposite the intraocular surgery. RESULTS: The average length of postoperative follow-up was 23.2 months (range, 1-94 months). Surgical, anesthetic, and postoperative complications, other than unsatisfactory ocular alignment, were limited to one retinal detachment in a patient with persistent fetal vasculature. Strabismic undercorrections (>12(Delta) of horizontal deviation or >5(Delta) of vertical deviation) occurred in 11 cases (37%). There were no overcorrections. A poor visual response (<20/50) to the intraocular surgery was encountered in 6 patients, all as the result of amblyopia or preexisting vitreoretinal pathology. CONCLUSIONS: Simultaneous extraocular muscle and lens surgery is an option for patients with strabismus and lens abnormalities. Standard strabismus surgical amounts are recommended.

Adolescent↗

Ocular findings in Gillespie-like syndrome: association with a new PAX6 mutation.

BACKGROUND: Gillespie syndrome is a rare variant form of aniridia, characterized by mental retardation, nonprogressive cerebellar ataxia, and iris hypoplasia. Unlike the more common dominant and sporadic forms of aniridia, there have been no associated PAX6 mutations or Wilms' tumor reported in Gillespie syndrome patients. Ocular findings in 21 cases published since Gillespie's initial description in 1965 include iris and foveal hypoplasia, nystagmus, and small optic discs with pigmentary retinopathy. CASE REPORT: We herein report a case of atypical Gillespie syndrome associated with bilateral ptosis, exotropia, corectopia, iris hypoplasia, anterior capsular lens opacities, foveal hypoplasia, retinal vascular tortuosity, and retinal hypopigmentation. Neurologic evaluation revealed a mild hand tremor and learning disability, but no ataxia or cerebellar abnormalities on neuroimaging. Sequencing studies revealed a substitution in intron 2 of the PAX6 gene (IVS2 + 2T > A). To our knowledge, this is the first mutation of PAX6 gene reported in association with a Gillespie-like syndrome.

Abnormalities, Multiple↗

Strabismus.

The various forms of strabismus present clinicians with interesting diagnostic and treatment dilemmas. The importance in distinguishing the various structural, neurosensory, and developmental forces at work in the interplay between visual acuity, binocularity, and oculomotor function keeps even experienced strabismologists occupied. It is hoped that this article may help pediatricians approach their strabismic patients with a fuller understanding of the subject.

Child↗