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Biomedical subjects

Benjamin Levy

Publications and source records attributed to Benjamin Levy.

3 recordsLinked to original sources

Immunologic therapies for gastrointestinal cancers.

The treatment of solid tumors has shown a dramatic change in recent years. This revolution has come from an improved understanding of the mechanisms of tumor growth and the relationship of cancers to their microenvironments. As part of this revolution, we have had a dramatic increase in our understanding of the immune system and the role it could play in the management of cancers. This article reviews the current data supporting the use of cancer immunologic therapies for gastrointestinal tract cancers. The scope is focused on the variety of approaches that have been used, citing the clinical data that have been obtained and reviewing future trials.

Antibodies, Monoclonal↗

TRICOM: enhanced vaccines as anticancer therapy.

Renewed interest in immune therapies for the treatment of cancer has sparked a number of different immune stimulation approaches. These include antibody based, dendritic cell-based and vaccine-based therapies. The poxvirus-based vaccines incorporating a TRIad of COstimulatory Molecules (TRICOM) will be reviewed here. Through stimulation of cancer-specific T-cell responses, researchers have demonstrated interesting clinical efficacy in addition to the high safety profile in clinical trials.

Cancer Vaccines↗