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Bernd J Wintersperger

Publications and source records attributed to Bernd J Wintersperger.

33 records · Page 2Linked to original sources
PubMed2005

Practical approaches to the evaluation of signal-to-noise ratio performance with parallel imaging: application with cardiac imaging and a 32-channel cardiac coil.

In this work, two practical methods for the measurement of signal-to-noise-ratio (SNR) performance in parallel imaging are described. Phantoms and human studies were performed with a 32-channel cardiac coil in the context of ultrafast cardiac CINE imaging at 1.5 T using steady-state free precession (SSFP) and TSENSE. SNR and g-factor phantom measurements using a "multiple acquisition" method were compared to measurements from a "difference method". Excellent agreement was seen between the two methods, and the g-factor shows qualitative agreement with theoretical predictions from the literature. Examples of high temporal (42.6 ms) and spatial (2.1x2.1x8 mm3) resolution cardiac CINE SSFP images acquired from human volunteers using TSENSE are shown for acceleration factors up to 7. Image quality agrees qualitatively with phantom SNR measurements, suggesting an optimum acceleration of 4. With this acceleration, a cardiac function study consisting of 6 image planes (3 short-axis views, 3 long-axis views) was obtained in an 18-heartbeat breath-hold.

Female↗
PubMed2005

Basics of cardiac MDCT: techniques and contrast application.

The purpose of this article is to review the basic techniques of cardiac MDCT including the most recent 64-slice scanner generation. Besides the technical developments of different MDCT generations within recent years, the basic principles of ECG-related CT algorithms are discussed. Retrospective ECG-gated data acquisitions are considered as a prerequisite for reliable and reproducible calcium scoring as well as for volumetric assessment of the coronary artery tree. While data acquisition itself is rather straightforward, the optimization of image quality, the knowledge of adequate scan protocols and especially knowledge of possibly arising artefacts is mandatory for a stable high image quality. As data acquisition is becoming faster with the most recent advent of 64-slice MDCT, protocols have to be adapted to this new scanner generation. On the other hand, the improvement in spatial as well as in temporal resolution shows impact on the accuracy and stability of coronary CT angiography. However, the use of dose-reducing technical improvements is strongly recommended.

Coronary Angiography↗
PubMed2005

Brain tumor enhancement in magnetic resonance imaging: comparison of signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) at 1.5 versus 3 tesla.

OBJECTIVE: The objective of this study was to compare the difference in lesion enhancement between 1.5 and 3 T using an extracellular gadolinium chelate in a rat brain glioma model. METHODS: Five rats (CDF Fischer 344) with implanted C6/LacZ brain gliomas were evaluated using matched T1-weighted spin echo techniques and hardware configurations at 1.5 and 3 T. Serial imaging over 10 minutes after gadoteridol (ProHance) administration was performed. Contrast enhancement (CE), signal-to-noise ratios (SNR) for brain and tumor, as well as contrast-to-noise ratios (CNR) were evaluated using region-of-interest (ROI) analysis at both field strengths. All gliomas were also evaluated by histopathology. RESULTS: CE at 3 T increased by 106% to 137% (all P<0.05) with maximum CE occurring at 5 minutes for both 1.5 and 3 T (9.8+/-2.2 vs 21.1+/-3.5; P=0.0004). At 3 T, SNR increased for normal brain by 66% to 76% (P<0.01) and SNR for tumor increased by 70% to 89% (P<0.01). CNR increased by 101% to 137% (P<0.05) depending on the time postcontrast. The highest CNR for both 1.5 T and 3 T occurred 5 minutes after contrast (1.5 T: 9.4+/-1.1 vs 3 T: 20.3+/-2.4; P<0.0004). CONCLUSION: Using a standardized animal model and matched scan techniques, this study shows a significant benefit of 3 T compared with 1.5 T in contrast-enhanced brain tumor magnetic resonance imaging.

Animals↗
PubMed2005

Cardiovascular screening with parallel imaging techniques and a whole-body MR imager.

The purpose of this study was to integrate parallel acquisition techniques into a comprehensive whole-body cardiovascular screening protocol to image all relevant organ systems without compromising spatial or temporal resolution. The study was approved by the institutional review board, and oral and written informed consent was obtained from each subject. Fifty subjects underwent whole-body magnetic resonance imaging that included imaging of heart, blood vessels, brain, lungs, and abdominal organs with a standard eight-channel imager. Image quality and pathologic findings were evaluated by two readers. The same protocol was then implemented with a new 32-channel whole-body imager. Depiction of 1476 (73.2%) of 2016 vessel segments was rated as good to excellent, and that of 1744 (86.5%), as without venous overlay. Interobserver agreement was good in evaluation of image quality and excellent in evaluation of pathologic findings. Acquisition time was reduced significantly (P < .05) with use of the whole-body imager and parallel acquisition techniques, which provided high-quality fast cardiovascular imaging.

Adult↗
PubMed2004

MDCT-imaging of peripheral arterial disease.

With the design and development of advanced computed tomography (CT) techniques and applications, like the newest generation of 16-detector-row CTs, CT angiography of the lower limb becomes a feasible tool for imaging peripheral vascular disease. Due to several advantages, compared with conventional digital subtraction angiography (DSA), including minimal invasiveness, CT angiography competes against diagnostic DSA in several clinical situations. 16-DCT offers the possibility to acquire thin slices from the diaphragm to the ankle in less than 40 sec. Easily, a data set of 800 to 1200 transverse slices may be created. To use transverse reconstructions alone to read these volumetric data sets is not appropriate. Powerful post-processing tools for volumetric analysis are required so that routine interpretation can be performed as efficiently and accurately as transverse section review. Because of its widespread availability and applicability, CT angiography of the lower extremities may be applied to patients in a pre- or post-procedural situation and also serves as a first line modality in patients with acute onset of clinical symptoms. Although multidetector CT arteriography is rapidly achieving clinical acceptance, further studies need to be performed to fully evaluate the clinical value of this method of peripheral arterial imaging. This article reviews the current status of multidetector CT peripheral arteriography, including indications, technical details, image post-processing, radiation exposure, and clinical results.

Angiography↗
PubMed2004

Multidetector-row CT angiography of the aorta and visceral arteries.

Within recent years, technical developments of multidetector-row CT (MDCT) have dramatically changed the application of CT angiography in the assessment of abdominal vascular pathologies. The simultaneous acquisition of multiple thin collimated slices in combination with enhanced gantry rotation speed offers thin slice coverage of extended volumes without any loss in spatial resolution. Using 4 detector-row CT scanners, the scan volume still has to be restricted and focused on dedicated abdominal vessel territories in order to provide high spatial resolution (1-2 mm), while 16 detector-row technology now enables full abdominal coverage from the diaphragm to the groin with full spatial resolution. Therefore, comprehensive CT angiography of the abdomen can be performed without the necessity of focusing on any vascular territory. This technique enables the evaluation of the whole arterial visceral vasculature (e.g., hepatic vessels, mesenteric vessels, renal arteries) and the aortic-iliac axis in a single data acquisition.

Angiography↗
PubMed2003

Multidetector-row computed tomography of the coronary arteries: predictive value and quantitative assessment of non-calcified vessel-wall changes.

The aim of this study was to quantitatively assess non-calcified coronary artery plaques and to determine their predictive value for the detection of coronary artery disease (CAD). A total of 179 patients underwent a calcium screening examination and a contrast-enhanced multidetector-row computed tomography angiography (MDCT) of the coronary arteries for various indications. The traditional calcium scores were evaluated and all examinations were reviewed for the presence of non-calcified plaques with an attenuation of 0-130 Hounsfield units (HU). The number, mean attenuation, and volume of these non-calcified plaques were recorded. All patients also underwent conventional catheter angiography. Coronary calcium was detected in 73% (131 of 179) of the patients. Overall incidence of purely non-calcified plaques was 30% (53 of 179). In 27% of the patients (48 of 179) no calcium was detected; however, 15% of these patients without calcifications showed non-calcified plaques (7 of 48). Significant correlations were found between the volume of calcified plaques, volume of non-calcified plaques, and total plaque volume. There were significant differences in plaque composition comparing different risk factor profiles and different stages of CAD. Volumetric assessment of non-calcified coronary artery plaques is feasible using contrast-enhanced MDCT. Screening for non-calcified plaques identifies patients with signs of CAD that are missed in a calcium screening examination.

Calcinosis↗
PubMed2003

Single breath-hold real-time cine MR imaging: improved temporal resolution using generalized autocalibrating partially parallel acquisition (GRAPPA) algorithm.

The purpose of this study was to test parallel imaging techniques for improvement of temporal resolution in multislice single breath-hold real-time cine steady-state free precession (SSFP) in comparison with standard segmented single-slice SSFP techniques. Eighteen subjects were examined on a 1.5-T scanner using a multislice real-time cine SSFP technique using the GRAPPA algorithm. Global left ventricular parameters (EDV, ESV, SV, EF) were evaluated and results compared with a standard segmented single-slice SSFP technique. Results for EDV ( r=0.93), ESV ( r=0.99), SV ( r=0.83), and EF ( r=0.99) of real-time multislice SSFP imaging showed a high correlation with results of segmented SSFP acquisitions. Systematic differences between both techniques were statistically non-significant. Single breath-hold multislice techniques using GRAPPA allow for improvement of temporal resolution and for accurate assessment of global left ventricular functional parameters.

Algorithms↗
PubMed2003

Ultra-low-dose coronary artery calcium screening using multislice CT with retrospective ECG gating.

The aim of this study was to reduce radiation exposure in multislice CT (MSCT) coronary artery calcium screening using different tube settings, and to determinate its impact on the detection and quantification of coronary artery calcification. Forty-eight patients underwent routine MSCT coronary artery calcium scoring (Somatom VolumeZoom, Siemens, Forchheim, Germany) with retrospective ECG-gated data acquisition. Scanning was performed with a 4 x 2.5-mm collimation. In each patient data acquisition was performed twice using tube settings of 120 kVp with 133 mAs (protocol 1) and of 80 kVp with 300 mAs (protocol 2). Together with the 80-kVp protocol additional online ECG-related tube current modulation (ECG pulsing) was used. Three-millimeter overlapping slices (increment 1.5 mm) were calculated for each data set. Semi-automated calcium quantification was performed calculating absolute Ca-hydroxylapatite mass. In addition to patient examinations, the radiation exposure for both protocols was evaluated using computed tomography dose index (CTDI) phantom measurements. Protocol 2 showed a significantly lower patient radiation exposure than protocol 1 (0.72 vs 2.04 mSv; p<0.0001). The CTDI phantom measurements revealed a 65% reduction of radiation dose. Calcium scoring results of both protocols showed a high correlation ( r=0.99; p<0.0001) for absolute Ca-Hydroxylapatite mass measurements. Using 80-kVp protocols patient radiation exposure can be significantly reduced in MSCT coronary artery calcium screening without affecting the detection and quantification of coronary artery calcification; therefore, this technique should be used with retrospective ECG-gated cardiac CT examinations in patients with regular sinus rhythm.

Calcinosis↗
PubMedDate not supplied

Assessment of myocardial infarctions using multidetector-row computed tomography.

OBJECTIVE: To evaluate the diagnostic power of contrast-enhanced multidetector-row computed tomography (MDCT) in assessing the presence, age, and size of myocardial infarctions. METHODS: One hundred six patients underwent standard MDCT coronary angiography without additional changes in the protocol. In all patients, a complete patient history and left heart catheterization with biplane contrast ventriculography were available. The MDCT images were reviewed for the presence and age of myocardial infarctions in a blinded fashion. Infarct areas were detected as regions of reduced uptake of contrast in the early arterial phase and/or regional wall thinning. Reviewing the computed tomography (CT) images, CT density values (Hounsfield units [HU]) were measured at the site of infarcted and noninfarcted myocardium, and a volumetric assessment of the infarct size was performed. RESULTS: In 27 of 106 patients, myocardial infarctions were present. Multidetector-row computed tomography detected 23 of 27 infarctions (sensitivity of 85%, specificity of 91%, and accuracy of 90%). Comparing the HU of infarcted versus noninfarcted myocardium, the mean HU of infarcted areas was 54 +/- 19 HU versus 117 +/- 28 HU for noninfarcted myocardium (P < 0.01). Multidetector-row computed tomography was able to differentiate between recent and chronic infarctions. The infarct volumes of recent infarctions (6.3 +/- 3.6 cm) showed a negative correlation to the ejection fraction (EF) according to contrast ventriculography (ie, the larger the infarct volumes as measured using MDCT, the worse was the EF [r = -0.72, P < 0.01]). CONCLUSIONS: Performing standard MDCT coronary angiography, areas of infarcted myocardium can be identified with moderate to high sensitivity, without additional scanning or contrast administration. Infarct localization can be assessed accurately as compared with cineventriculography. To some degree, infarct age and infarct volume can be estimated.

Aged↗
PubMedDate not supplied

Assessment of global left ventricular function: comparison of cardiac multidetector-row computed tomography with angiocardiography.

OBJECTIVE: Evaluation of left ventricular function using electrocardiogram (ECG)-gated multidetector row CT (MDCT) by using 3 different volumetric assessment methods in comparison to assessment of the left ventricular function by invasive ventriculography. METHODS: Thirty patients with suspected or known coronary artery disease underwent MDCT coronary angiography with retrospective ECG cardiac gating. Raw data were reconstructed at the end-diastolic and end-systolic periods of the heart cycle. To calculate the volumes of the left ventricle, 3 methods were applied: The 3-dimensional data set (3D), the geometric hemisphere cylinder (HC), and the geometric biplane ellipsoid (BE) methods. End-diastolic volumes (EDV), end-systolic volumes (ESV), the stroke volumes (SV), and ejection fractions (EF) were calculated. The left ventricular volumetric data from the 3 methods were compared with measurements from left ventriculography (LVG). RESULTS: The best results were obtained using the 3D method; EDV (r = 0.73), ESV (r = 0.88), and EF (r = 0.76) correlated well with the LVG data. The EDV volumes did not differ significantly between LVG and the 3D method (P = 0.24); however, ESV, SV, and EF differed significantly. The ESV were significantly overestimated (P < 0.01), leading to an underestimation of the SV (P < 0.01) and the EF (P < 0.01). The HC method resulted in the greatest overestimation of the volumes. The EDV and the ESV were 31.8 +/- 37.6% and 136.4 +/- 92.9% higher than the EDV and ESV volumes obtained by LVG. Bland-Altman analysis showed systematic overestimation of the ESV using the HC method. CONCLUSION: MDCT with retrospective cardiac ECG gating allows the calculation of left ventricular volumes to estimate systolic function. The 3D method had the highest correlation with LVG. However, the overestimation of the ESV is significant, which led to an underestimation of the SV and the EF.

Adult↗