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Biomedical subjects

Bernd Schönhofer

Publications and source records attributed to Bernd Schönhofer.

9 recordsLinked to original sources

[Intermediate care units and noninvasive ventilation].

Intermediate care units (IMC) have been introduced to provide optimal patient management according to disease severity and to bridge the gap between intensive care (ICU) and general wards. Most patients that are referred to an IMC need monitoring and intensive analgetic treatment. Over the past years noninvasive ventilation (NIV) and weaning have emerged as important new forms of active treatment in the IMC. Most studies that have been published so far demonstrate that an IMC improves patient outcome and lowers costs, although randomized controlled trials are missing. NIV reduces mortality, the need for intubation as well as ICU and hospital length of stay in patients with chronic obstructive pulmonary disease (COPD) and other disorders that cause respiratory failure. In many cases NIV can be performed in the IMC, a fact that reduces the number of ICU admissions, lowers costs and improves patient care. The high prevalence of pulmonary diseases and NIV emphasizes the importance of pneumologists as directors of both ICU and IMC.

Analgesics↗

Effect of home mechanical ventilation on inspiratory muscle strength in COPD.

BACKGROUND: The mechanism responsible for chronic hypercapnic respiratory failure (HRF) in patients with COPD remains unclear. In this study, we tested the hypothesis that chronic HRF in patients with COPD is associated with low-frequency fatigue (LFF) of the diaphragm. METHODS: To test this hypothesis, we measured the twitch transdiaphragmatic pressure (Tw Pdi) elicited by stimulation of the phrenic nerves in 25 patients with chronic HRF (mean [+/- SD] Paco(2), 55.2 +/- 5.2 mm Hg) due to COPD before and 2 months after the initiation of noninvasive mechanical ventilation (NIV) [pressure-cycled ventilation with inspiratory positive airway pressure of 19.0 +/- 2.5 cm H(2)O]. We reasoned that had LFF been present, Tw Pdi should rise after effective NIV. RESULTS: The treatment compliance with NIV was good (median of machine usage was 7.1 h per night). Paco(2) decreased from 55.2 +/- 5.2 to 48.8 +/- 5.9 mm Hg (p < 0.001), and Pao(2) increased from 53.1 +/- 5.9 to 57.7 +/- 7.0 mm Hg (p = 0.007). Mean Tw Pdi at baseline was 11.1 +/- 6.6 cm H(2)O and after treatment was 11.7 +/- 7.2 cm H(2)O (not significant). Also, maximal static inspiratory mouth pressure did not change significantly (44.3 +/- 15.9 cm H(2)O vs 46.5 +/- 19.7 cm H(2)O). CONCLUSION: LFF of the diaphragm does not accompany chronic HRF in patients with COPD.

Aged↗

Health-related quality of life in patients with chronic respiratory failure after long-term mechanical ventilation.

STUDY OBJECTIVES: This study was aimed at assessing health-related quality of life (HRQL) in patients with chronic respiratory failure (CRF) and long-term survival following prolonged intensive care mechanical ventilation. DESIGN: Observational cohort study. SETTING: Patients with CRF who had been transferred to our specialized weaning centre due to prolonged mechanical ventilation (>14 days) and weaning failure. PATIENTS AND PARTICIPANTS: Out of 87 long-term survivors (>6 months), 73 patients (mean age: 60.3+/-13.6 years, chronic obstructive pulmonary disease (COPD, 43%), thoraco-restrictive (21%) or neuromuscular disorders (15%), various chronic diseases (22%)) returned the MOS 36-Item Short-Form Health Status Survey (SF-36) and the St. George's respiratory questionnaire (SGRQ). MEASUREMENTS AND RESULTS: The total ventilation time was 38.7+/-45.9 days. The time between discharge from ICU and HRQL assessment was 31.0+/-22.2 months. Physical health was markedly reduced compared to general population norm, but mental health was mildly impaired. HRQL was comparable to patients with stable CRF receiving non-invasive ventilation who did not need prolonged invasive MV. In addition, general HRQL was better in patients with restrictive respiratory disease compared to patients with neuromuscular diseases (P<0.05). Physiological parameters such as blood gases or lung function parameters were not correlated to any HRQL measurements. CONCLUSIONS: In patients with CRF surviving prolonged ventilation on ICU, the presence of CRF itself is the major determinant of HRQL. Here, the underlying cause of CRF is the major factor which determines the degree of HRQL impairment with patients suffering from restrictive ventilatory disorders reporting the best HRQL when compared to patients with COPD or neuromuscular diseases. Despite severe physical handicaps due to CRF mental health is only mildly compromised.

Aged↗

Transesophageal echographic determination of aortic invasion by lung cancer.

BACKGROUND: In planning lung cancer therapy, the possibility of mediastinal invasion merits attention. The results of CT and MRI in this respect are unsatisfactory, especially in determining aortic involvement. STUDY OBJECTIVES: To determine the validity of transesophageal echography in proving the invasion of lung cancer into the aortic wall. PATIENTS: Two hundred one patients with lung cancer abutting against the aorta were examined using transesophageal echography and CT. In 97 patients, the results of both imaging techniques were compared with the surgical/pathologic results. RESULTS: In a vast majority, transesophageal echography leads to a definitive result while CT remains equivocal. Controlled by surgical/pathologic results in 97 patients, transesophageal echography yielded a diagnostic accuracy of 91.8%. CONCLUSIONS: In lung cancer abutting against the aorta, the diagnostic procedure should be complemented by transesophageal echography if the therapeutic management depends on whether the aortic wall is invaded by the tumor or not.

Aged↗

Sterile water is unnecessary in a continuous positive airway pressure convection-type humidifier in the treatment of obstructive sleep apnea syndrome.

OBJECTIVE: We investigated the necessity of using sterile water in humidifiers for avoiding respiratory tract infections during nasal continuous positive airway pressure (nCPAP) therapy. METHODS: Water in a convection-type humidifier (Sirius; Heinen and Löwenstein GmbH; Bad Ems, Germany) was labeled with (99m)Tc-diethylenetriamine penta-acetic acid. Low-flow (2 L/min, 4 L/min, or 6 L/min) and high-flow (31 to 46 L/min) rates were applied, rates typical for nCPAP. Heat and moisture exchange filters were placed behind the start of the tube to measure any radioactive aerosol. RESULTS: We demonstrated that no radioactive aerosols were produced, either with low or high flows. CONCLUSIONS: The convection-type humidifier produces water vapor but does not aerosolize the water. We conclude that bacteria, other microorganisms, or even solutes that may be contained in the water cannot be transported into the air and thus will not be deposited in the lung. In order to avoid respiratory tract infections, sterile water is not required, at least in this particular humidifier. We suggest that nonsterile tap water is probably a safe alternative.

Aerosols↗

Non-invasive mechanical ventilation improves walking distance but not quadriceps strength in chronic respiratory failure.

BACKGROUND: In patients with chronic respiratory failure (CRF) nocturnal mechanical ventilation (NMV) confers increased exercise tolerance. The hypothesis tested in the present study was that the increased exercise performance is associated with increased quadriceps strength. METHODS: In 28 patients with CRF due to chronic obstructive pulmonary disease and restrictive thoracic disease (post-tuberculosis-sequelae, scoliosis and obesity-hypoventilation) NMV was started. Before and after 2-month NMV the exercise tests, namely shuttle and 6-min walking distance, were performed. Furthermore, quadriceps strength was measured as the twitch tension elicited by magnetic stimulation the femoral nerve (TwQ) and the maximum voluntary contraction force (MVC). RESULTS: After 2 months therapy with NMV there was significant clinical and blood gas improvement. NMV significantly improved the walking distance by approximately 18% but there was no improvement in TwQ or MVC, the data could exclude a 15% improvement in TwQ with 82% confidence. CONCLUSION: The strength of quadriceps does not change after 2 months of effective NMV in patients with CRF despite a marked increase in endurance time. Factors other than quadriceps strength account for the improved performance.

Activities of Daily Living↗

Effect of nasal valve dilation on effective CPAP level in obstructive sleep apnea.

Nasal problems are frequent at high continuous positive airway pressure (CPAP). We hypothesized that a reduction of the nasal resistance reduces CPAP and investigated the effect of a nasal valve dilator (Nozovent) on CPAP in patients with obstructive sleep apnea. In a randomized cross-over design Nozovent was inserted in 38 patients during one of two nights using AutoSet T. CPAP differences > 1 cm H2O were considered as clinically relevant. With Nozovent the median CPAP pressure was reduced from 8.6 cm H2O to 8.0 H2O (P = 0.023) in all patients, but the number of patients with a reduction of CPAP by 1 cm H2O was not significant. The median CPAP level among 20 patients requiring a CPAP level of above 9 cm H2O was reduced from 10.3 to 9.1 cm H2O, P < 0.05. A clinical improvement with Nozovent was seen in 10 of 20 patients requiring a pressure of above 9 cm H2O compared with 4 of 18 patients who needed lower pressures, P = 0.025. Nozovent reduces the CPAP level 1 cm H2O in 50% of patients requiring a high pressure (> 9 cm H2O). Future studies should identify possible patients benefiting from a nasal dilator during CPAP therapy.

Airway Resistance↗

[Sexuality in patients with restricted breathing].

BACKGROUND: Sexuality in chronic diseases is of increasing significance. In the majority of patients with chronic lung diseases, sexual activity is reduced. Most available data on this topic are based on patients with chronic obstructive pulmonary diseases (COPD). PATHOGENESIS: Dyspnea, cough, muscular weakness, and the associated reduction of physical activity are the main causes of reduced sexual activity in COPD patients. In addition to direct somatic-physical effects of COPD, the associated psychosocial deficits and adverse effects of medication contribute to sexual dysfunction. TREATMENT: An intact communication between physician and patient is an important issue within a therapeutic strategy. Applying both treatment and behavioral strategies enables even patients with severe lung diseases to be sexually active. Somatic therapy consists of both systemic medication and local interventions to treat sexual dysfunction. If oxygen therapy is indicated, it should be administered also during intercourse. In patients with chronic ventilatory failure, sexual activity may profit from noninvasive mechanical ventilation.

Combined Modality Therapy↗

Choice of ventilator types, modes, and settings for long-term ventilation.

Ventilator-associated issues are important for optimum short- and long-term outcome in patients treated with long-term mechanical ventilation, and may even influence compliance. This article discusses the individual choice of type, modeand settings ventilators, based on the efficacy of the intervention and patient-related factors, such as the patient's comfort and safety. Although this strategy may cause some overlap, from a methodological point of view it seems reasonable to deal separately with types, modes and different ventilator settings.

Chronic Disease↗