Biomedical subjects

Betty L Thompson

Publications and source records attributed to Betty L Thompson.

2 recordsLinked to original sources

PubMed2003

Investigation of the early stages in soraphen A biosynthesis.

The unusual benzoate starter unit in soraphen A derives from phenylalanine via cinnamate in a beta-oxidative (plant-like) pathway; 3-phenyl-3-hydroxypropanoate incorporates directly into soraphen by loading onto module 2 of the PKS and indirectly from the beta-oxidative pathway to generate benzoyl CoA.

Antifungal Agents↗

PubMed2003

Novel soraphens from precursor directed biosynthesis.

Six novel halogenated soraphen analogues have been isolated from the wild-type producing organism using precursor directed biosyntheses; the best 'delivery vehicle' for the novel starter acids was cinnamate but ortho substituents were not tolerated by the soraphen PKS.

Antifungal Agents↗