Biomedical subjects

Biljana Vuletić

Publications and source records attributed to Biljana Vuletić.

4 recordsLinked to original sources

PubMedDate not supplied

[Report of a newborn with hemimegalencephaly in association with Klippel-Trenaunay-Weber syndrome].

Klippel-Trenaunay-Weber syndrome (KTW) is a rare phacomatosis whose main characteristics are: cutaneous angiomas (vascular nevi), varicose veins (arteriovenous fistulae) and hemihypertrophy of bones and soft tissues. This is a case report of KTW syndrome which was diagnosed in the first days of life on the basis of characteristic vascular nevi on the skin of the trunk and extremities in addition to hypertrophy of the left part of the body. Neuroradiologically verified hemimegalencephaly associated with temporal hemangioma represents a special particularity in our case. Measures of monitoring the child as well as stimulating and therapeutic actions were the issues of discussion.

Brain↗

PubMedDate not supplied

[Brain abscesses in neonates: neurosonographic diagnosis and long-term follow-up].

Brain abscesses were neurosongraphically diagnosed in 3 out of 44 neonates who had confirmed purulent meningitis. In two cases, the cause was Proteus mirabillis, whereas in one the cause could not be isolated. The ultrasound finding indicated abscess cavities localised in the frontal (in one case bilaterally) and temporal regions of the CNS. Neurosurgical interventions were carried out on all of the neonates who had abscesses (including the evacuation of purulent cavity contents, and later on a ventriculoperitoneal shunt in two cases, because of the development of hydrocephalus). Follow-up on the operated infants revealed that one infant died at the age of 9 months; one, who had a bilateral abscess, demonstrated significant neurodevelopmental retardation in the third month of his life (so far it has not been brought under control); while the third one, whom we monitored until the age of 2, displayed regular psychomotor development (preserved intellect, motor skills, sight, and hearing).

Brain Abscess↗

PubMedDate not supplied

[Molecular epidemiology of rotaviruses in preschool children].

Numerous epidemiological studies, conducted in both developed and developing countries, have shown that the rotavirus is an important aetiological agent in severe diarrhoeal diseases among preschool children. In recent years, different biochemical techniques for the genetic and phenotypic analysis of rotaviruses have been developed. The aim of this study was to define the biological and genetic differences among rotaviruses isolated from the faeces of affected children, by using the Polyacrylamide Gel Electrophoresis technique, as well as to type the viruses and establish the number of strains circulating within our population. In total, 124 faeces samples from children up to 5 years of age were analysed. With the use of the ELISA test, rotaviruses were isolated in 10.3% of cases. The extraction of viral RNA was carried out directly from the faeces samples, which was followed by electrophoresis, and finally observation using a UV lamp, and documentation with a photo camera. The analysis of viral RNA, using Polyacrylamide Gel Electrophoresis (PAGE), revealed equal mobility in all segments of the genome. The results of our analysis demonstrated that the same strains of rotaviruses do circulate within our population. Such a result can be explained as a consequence of our years-long isolation as well as of the decreased mobility of our population. However, the results do not signify that the rotavirus genome in this region will not be susceptible to variations and that, consequently, new strains will not be created.

Child, Preschool↗

PubMedDate not supplied

[Rotavirus gastroenteritis].

Rotavirus is the main etiological agent that causes severe diarrheal diseases in newborns and young children up to two years. Every year, about one million children around the globe die of dehydration caused by Rotaviruses. The problem is even bigger in underdeveloped and developing countries. The results of our 18-month research, in the town Kragujevac and its surrounding area from December 1998 to May 2000 indicate that viruses are an important factor in the etiology of the acute diarrheal diseases in our population. In 124 children, aged 0 to 5, with the acute diarrheal diseases treated at the Pediatric clinic HMC "Kragujevac", viruses were the causes in 27% of the time. The Rotavirus belongs to the family Reoviridae. The infections caused by rotaviruses may be detected around the world. The incidence rate is higher in developed countries. The infection is transmitted orally. The entry of the Rotavirus infection is the upper part of the small intestine. The clinical picture is specific. The disease usually lasts four to seven days. The fastest diagnostic method is direct detection of viruses using the electronic microscope. The agglutination tests ELISA and LATEX are used for the examination of numerous samples. Only symptomatic treatment is required. High morbidity and mortality rates in developing countries are the reason to prevent the Rotavirus disease by active immunization.

Child, Preschool↗