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Brad W Neville

Publications and source records attributed to Brad W Neville.

11 recordsLinked to original sources
PubMed2006

Oral premalignant lesions induce immune reactivity to both premalignant oral lesions and head and neck squamous cell carcinoma.

Head and neck squamous cell carcinoma (HNSCC) is an aggressive malignancy, and despite advances in treatments, the 5-year survival has remained at less than 50%. One treatment strategy is to focus on patients with premalignant oral lesions that carry a high-risk for developing recurrent premalignant lesions and HNSCC disease. As an initial attempt to determine if immune therapy has the potential to be protective in these patients, studies determined if premalignant lesions express tumor antigens that have previously been shown to be expressed on HNSCC. Immunohistochemical analyses showed prominent expression of epidermal growth factor receptor in premalignant lesions, even in lesions with mild dysplasia. MUC-1 and carcinoembryonic antigen were expressed in most patient samples, while NY-ESO-1 was less frequently expressed. Each of these antigens was expressed on HNSCC. This provided the rationale for determining if premalignant oral lesions could be used to stimulate autologous peripheral blood mononuclear leukocytes (PBML) to react against heterologous premalignant lesions and HNSCC. Following sensitization with autologous premalignant lesions, PBML responded to a challenge with either heterologous premalignant oral lesion cells or HNSCC by releasing IFN-gamma. In addition, sensitization with autologous premalignant lesion lysates generated cytolytic activity by both PBML and T cells against allogeneic premalignant lesion cells and HNSCC. These studies show the feasibility of using premalignant oral lesions to stimulate immune reactivity against both premalignant oral lesions as well as HNSCC.

Antigens, Neoplasm↗
PubMed2006

AAOMP case challenge: a solitary gingival nodule.

A 38-year-old Hispanic female presented for evaluation of a gingival nodule of eight months duration. The nodule, which was slightly painful to palpation, had increased in size over time. The patient denied any history of trauma to the area.

Adult↗
PubMed2005

AAOMP case challenge: painful oral ulcers.

This 33-year old Caucasian female presents complaining of a history of recurrent oral ulcers since childhood. In the past these ulcers typically lasted approximately 7-10 days and recurred every few months. However, more recently she has developed more persistent areas of irritation and ulceration, which tend to come and go. The patient reports the most severe areas of involvement to be the buccal mucosa bilaterally and the lateral tongue. Although in the past her braces seemed to exacerbate her condition, she has not noted significant improvement despite recent removal of her braces by her orthodontist.

Adult↗
PubMed2005

Epithelioid hemangioendothelioma of the oral cavity: report of two cases and review of the literature.

The epithelioid hemangioendothelioma is an uncommon vascular neoplasm of borderline or intermediate malignant potential. Although numerous sites of involvement are possible, these tumors most commonly arise in soft tissue, liver, and lung. Involvement of the oral cavity is rare. Only 12 cases of intraoral epithelioid hemangioendothelioma have been reported in the English language literature. We review the salient features of these previously reported cases and present 2 additional intraoral cases--one presenting as an asymptomatic radiolucency in the posterior mandible of a 23-year-old female, and the other presenting as an asymptomatic, erythematous to purplish gingival nodule in a 28-year-old female. Intraoral tumors most commonly involve the gingival soft tissues and often are associated with adjacent alveolar bone resorption. Although it is not possible to estimate with accuracy the potential for recurrence and metastasis among intraoral tumors given the small number of previously reported cases, wide local excision with close clinical follow-up appears to be the treatment of choice for these tumors because of their unpredictable clinical behavior.

Adult↗
PubMed2004

AAOMP case challenge: Multiple painful oral ulcers.

A 66-year old white male was referred with a chief complaint of multiple painful oral and pharyngeal ulcerations (Figure 1). He stated his symptoms began four months earlier with the occurrence of a mild sore throat, which was followed by the development of numerous ulcers throughout the rest of his mouth. Because of the pain from these lesions, the patient suffered from dysphagia and resultant weight loss.

Aged↗
PubMedDate not supplied

Oral cancer and precancerous lesions.

In the United States, cancers of the oral cavity and oropharynx represent approximately three percent of all malignancies in men and two percent of all malignancies in women. The American Cancer Society estimates that 28,900 new cases of oral cancer will be diagnosed in 2002, and nearly 7,400 people will die from this disease. Over 90 percent of these tumors are squamous cell carcinomas, which arise from the oral mucosal lining. In spite of the ready accessibility of the oral cavity to direct examination, these malignancies still are often not detected until a late stage, and the survival rate for oral cancer has remained essentially unchanged over the past three decades. The purpose of this article is to review the clinical features of oral cancer and premalignant oral lesions, with an emphasis on early detection.

Carcinoma, Squamous Cell↗