Antiangiogenic therapy in metastatic prostate carcinoma complicated by cutaneous lupus erythematodes.
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Angiogenesis Inhibitors↗
Biomedical subjects
Brigitte Coras
Publications and source records attributed to Brigitte Coras.
Fibroadenoma of the axilla.
BACKGROUND: Ectopic, axillary breast tissue can develop any disease that affects the normal breast, including fibroadenoma. OBJECTIVE: To report and discuss a case of fibroadenoma of the axilla in a 23-year-old woman. METHODS: Case report and discussion of the rare entity of fibroadenoma of the axilla. RESULTS: The histology was identical to the fibroadenomas seen in the breast and those observed along the milk line. CONCLUSION: Differential diagnosis of an axillary tumor should include ectopic breast tissue.
Adult↗
Comparison of two absorbable monofilament polydioxanone threads in intradermal buried sutures.
BACKGROUND AND OBJECTIVES: Two absorbable polydioxanone threads are compared regarding intraoperative handling qualities, scar dehiscence, and possible side effects. METHODS: In 30 excisions, half of each suture was performed with PDS II (Ethicon GmbH, Norderstedt, Germany), whereas the other half was closed with Serasynth (Serag-Wiessner, Naila, Germany). Clinical evaluation for scar spreading, spitting of the sutures, hypertrophic scarring, or suture granuloma was performed 3 and 6 months after surgery. RESULTS: No significant difference in scar spreading, hypertrophic scarring, or the incidence of suture granuloma was noted. A significantly lower frequency of spitting was seen with Serasynth than with PDS. The handling and suturing properties of SerasynthM were estimated to be slightly superior compared with those of PDS. CONCLUSION: Our study shows that PDS and Serasynth provide equal cosmetic results when applied in an appropriate suturing technique. Possibly owing to its better pliability, the frequency of spitting was lower with Serasynth.
Absorbable Implants↗
Congenital cartilaginous rests of the neck (wattles).
BACKGROUND: Congenital cartilaginous rests of the neck (wattles) are very rare, probably branchiogenic malformations. OBJECTIVE: To discuss the clinical and histologic features and the therapy of wattles. METHODS: We report a 4-year-old patient with symmetric exophytic nodules of the neck that had been present since birth. RESULTS: The two lesions, 0.5 3 0.5 cm, were removed. The histopathologic examination confirmed ectopic cartilaginous tissue. CONCLUSION: Wattles must be excised, including their cartilaginous core, after having sonographically excluded fistulae or sinuses.
Cartilage Diseases↗
Early recurrence of eruptive vellus hair cysts after Er:YAG laser therapy: case report and review of the literature.
BACKGROUND: Therapy of eruptive vellus hair cysts (EVHCs) often leads to unsatisfying results or recurrences. Recently, erbium:yttrium-aluminum-garnet (Er:YAG) laser therapy has been recommended in this condition. OBJECTIVE: To report the results of Er:YAG laser treatment and discuss the treatment options in EVHC, presenting a review of the literature. METHODS: Full-face Er:YAG laser therapy was performed in a 30-year-old female patient with a 15-year history of cosmetically bothersome facial EVHCs. RESULTS: Immediately after the laser treatment, the ablated skin showed an even surface, presenting no residual signs of EVHCs. After reepithelialization, however, early recurrence of EVHCs occurred. Recurrence was also observed in the previously treated test spot, where slight atrophy indicated deeper ablation. CONCLUSION: Er:YAG laser therapy might be a treatment option for distinct lesions of EVHCs but proved to be ineffective in a case of EVHCs in the face, where the depth of ablation is limited owing to the risk of atrophy or scarring and where deep enucleation of distinct single cysts was not possible owing to the dense dissemination of the lesions. Despite numerous treatment options reported in the literature, therapy for EVHCs is still challenging owing to recurrences or side effects.
Adult↗
Antiangiogenic therapy with pioglitazone, rofecoxib, and trofosfamide in a patient with endemic kaposi sarcoma.
BACKGROUND: Kaposi sarcoma (KS) in patients who are seronegative and seropositive for human immunodeficiency virus is currently the most common malignant tumor in central Africa. It accounts for 50% of all tumors reported in central African countries. Owing to the rising number of patients and the limitations of current therapies, there is an urgent demand for new strategies to treat KS. OBSERVATION: We describe a 42-year-old dark-skinned patient from Mozambique with endemic KS. The tumor was first diagnosed 8 years earlier when an ulcerated nodule appeared at his right ankle joint. Subsequently, multiple reddish brown nodules appeared on both feet and the left thigh. Results of dermatohistopathological analysis confirmed the diagnosis of KS. Topical therapies including cryotherapy, carbon-dioxide laser, and photodynamic therapy could not prevent new recurrences and further cutaneous dissemination. Therefore, a novel antiangiogenic systemic therapy was started that was previously shown to be effective in angiosarcomas other than KS. The regimen consists of the biomodulators pioglitazone hydrochloride and rofecoxib combined with a metronomic (daily) low-dose chemotherapy with trofosfamide. We observed a partial remission, which has been stable for 18 months. No significant toxic effects were observed. CONCLUSION: The suggested antiangiogenic strategy has the potential to become a cheap, practical, feasible alternative treatment for endemic KS, particularly suitable for the outpatient setting.
Adult↗
[The "red melanoma"--a rare form of amelanotic malignant melanoma].
The two major variants of amelanotic malignant melanoma are the verrucous and the polypoid forms. A further--albeit rare--red eczematous variety has also been described. We report two female patients with reddish, non-pigmented, scaly lesions on the upper arm and the shoulder that had developed 2 to 3 years previously. One biopsy showed the diagnosis of a melanoma growing in situ while the second revealed a highly atypical melanocytic tumour. However, the histopathological examination of the entire tumour showed a superficial spreading amelanotic malignant melanoma. Therefore, in non-healing erythematous lesions, even without pigmentation or ulceration, the rare differential diagnosis of amelanotic malignant melanoma should be taken in consideration and a biopsy should be performed prior to therapy without histological control.
Aged↗
[Porokeratotic eccrine ostial and dermal duct naevus (PEODDN)].
The porokeratotic eccrine ostial and dermal duct naevus or PEODDN represents a very rare hamartoma of the eccrine sweat glands. A 16-year old boy had developed subtle hyperkeratotic skin lesions on his right hallux at six months of age. When he was eight years old, he developed similar lesions on his right palm. Clinically the lesions were coniform hyperkeratoses. The histopathological examination confirmed the diagnosis of a PEODDN showing typical cornoid lamella where the eccrine secretory ducts penetrated the epidermis. Although porokeratotic eccrine ostial and dermal duct naevi are generally considered as unresponsive to conservative treatment, in our patient topical treatment with tazarotene gel 0.1% resulted in a significant improvement within three weeks.
Administration, Topical↗
Spindle cell hemangioma.
BACKGROUND: Spindle cell hemangioma (SCH) is an uncommon benign vascular tumor. OBJECTIVE: To report and discuss a case of SCH in an 11-year-old boy. METHODS: A case report and discussion of the rare entity of SCH are given. RESULTS: The excision of a vascular tumor showed a vascular connection to the great saphenous vein. Histologic examination was consistent with SCH. CONCLUSION: The diagnosis of SCH is supported by typical histologic and immunohistochemical features and by the intraoperative finding of an association with a large vessel.
Child↗
Post-traumatic iatrogenic aggravation of eruptive collagenomas in a child.
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Child↗
Rosai-Dorfman disease with cutaneous manifestation (sinus histiocytosis with massive lymphadenopathy).
We report a 73-year-old woman with the typical findings of "Rosai-Dorfman disease" (RDD) including massive, painless lymphadenopathy, fever and multiple, asymptomatic cutaneous lesions on her face, collum and neck. Histologically, the lesions were marked by characteristic large macrophages exhibiting emperipolesis.
Aged↗