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Biomedical subjects

Bruce Elliott

Publications and source records attributed to Bruce Elliott.

At least 19 recordsLinked to original sources
PubMed2006

5. Recent advances in sports medicine.

New research has changed our perception and management of common injuries. Magnetic resonance imaging and arthroscopy of the hip have shown that labral injuries, chondral injuries, rim lesions, synovitis and tears of the ligament teres are common causes of hip, groin and low-back pain. Hip arthroscopy is used both as a diagnostic and therapeutic tool; it has been shown to be of benefit in recent traumatic labral injury, but disappointing in the management of chronic hip pain (which may be associated with degenerative change, and chondral lesions of the acetabulum). The McConnell multimodal physiotherapy regimen is effective in treating patellofemoral pain. Anterior cruciate ligament rupture is three to five times more common in women, but neuromuscular training appears to decrease its incidence. Patellar tendon and hamstring grafts appear to be equally effective in anterior cruciate ligament reconstruction. Articular cartilage defects remain a significant problem, and the efficacy of treatments such as autologous chondrocyte implantation is still unclear.

Adolescent↗
PubMed2006

The relationship between shoulder alignment and elbow joint angle in cricket fast-medium bowlers.

The aim of this study was to examine the relationship between shoulder alignment and elbow angle during the delivery action of fast-medium bowlers. The elbow and upper trunk alignment were recorded for 13 high-performance bowlers (mean age 20 years) using a 12-camera Vicon motion analysis system operating at 250 Hz. The three highest velocity trials for "good" and "short" length deliveries were analysed. Results showed that bowlers with a more front-on shoulder alignment at back-foot impact and when the upper arm was horizontal to the ground experienced a significantly greater elbow flexion--extension range when compared with those who had a more side-on orientation at the same point in the delivery action. Bowlers with greater shoulder counter-rotation also recorded higher elbow flexion and subsequently extension during the period from upper arm horizontal to ball release. Shoulder alignment and elbow angles were similar for "short" and "good" length deliveries. It was concluded that bowlers with a more front-on shoulder orientation at back-foot impact demonstrated a higher elbow extension from upper arm horizontal to ball release and are therefore more likely to infringe International Cricket Council elbow tolerance levels, compared with those who adopt a more side-on shoulder orientation at back-foot impact.

Adult↗
PubMed2006

Performance tolerance and boat set-up in elite sprint kayaking.

The aim of this study was to examine the inter-relationship between athlete morphology, equipment set-up and performance in elite sprint kayaking. Correlations applied to data from the 2000 Olympics were used to select the most important links between morphology and boat set-up--paddle grip width and foot-bar distance. Associations between body size and the above selected equipment set-ups were calculated using a Pearson correlation matrix, to facilitate the logical selection of independent variables as input for regression analyses. Significant (p < 0.01) regression equations were developed for the prediction of foot-bar distance (r2 = 0.589: standard error of estimate (SEE) = 4.48) and paddle grip width (r2 = 0.541: SEE = 3.08). Three national-standard sprint kayakers used their preferred set-up together with modifications of their predicted set-up, derived from Olympic data, to test performance tolerance in sprint kayaking. Mean coefficients of multiple determination over three trials for the three paddlers of 0.91, 0.91 and 0.92 for left paddle force, right paddle force, and paddle angle at water entry, respectively, were recorded when using their preferred set-up. These data showed that the paddlers produce consistent patterns of motion. The intervention of altering the boat set-up resulted in varying changes to boat speed. The mean preferred speed for the three paddlers of 4.47 m/s was reduced by 0.07 and 0.10 m/s when the above boat set-up was modified to a predicted and 'predicted plus one standard deviation'respectively. These changes in boat speed were the result of alterations in the mechanics of paddling technique.

Adult↗
PubMed2006

Telehealth home health applications for adults with developmental disabilities.

Telehealth technology for application in home healthcare for adult persons with developmental disabilities was examined. Utilization of telehealth by clinicians, including the physician, nurse and physician assistant, physical therapist, occupational therapist, speech language pathologist, the dietitian, and psychologist for the healthcare needs of adults with developmental disabilities is discussed. Such utilization results in improved access to needed health services by reducing time and distance for this population. A telehealth model is offered, as are shifts in healthcare using telehealth technology in home health.

Adult↗
PubMed2005

The effect of altered pitch length on performance and technique in junior fast bowlers.

The aim of this study was to assess the effect of pitch length (20.12 m [full length], 18 m and 16 m) on the fast bowling performance and technique of junior cricketers. Performance measures included ball release speed and accuracy, while technique variables evaluated were those shown to be related to the aetiology of lower back injury. Thirty-seven fast bowlers from the under-11 (n=14), under-13 (n=11) and under-15 (n=12) age groups were filmed bowling five deliveries at each of the above pitch lengths. Two synchronized NAC video cameras operating at 200 Hz permitted three-dimensional reconstruction of the hip and shoulder alignments, while a standard digital video camera operating at 50 Hz (positioned perpendicular to the bowling action) was used to measure front knee angle and ball release speed. Accuracy scores were taken from a zoned target at the batsman's stumps. A two-way analysis of variance with repeated measures (with age and pitch length as the between- and within-participant variables, respectively) was used to compare each age group at the 0.05 significance level. Results showed that accuracy improved in all age groups at shorter pitch lengths, although ball velocity remained constant throughout all trials. Shoulder counter-rotation increased significantly for the under-13 bowlers when bowling on the full-length pitch in comparison with the two shorter lengths. Counter-rotation also increased on the full-length pitch in the under-11 age group, although this increase was not significant. The under-15 bowlers' techniques did not change as pitch length increased. As under-11 and under-13 bowlers adopted a "safer" bowling action with superior accuracy on the 18?m compared with the full length pitch, it was concluded that these age groups should bowl on an 18?m pitch to reduce the likelihood of lower back injuries and improve accuracy.

Adolescent↗
PubMed2004

Cell-to-cell adhesion modulates Stat3 activity in normal and breast carcinoma cells.

Stat3 (signal transducer and activator of transcription-3) activity is required for transformation by a number of oncogenes, while a constitutively active form of Stat3 alone is sufficient to induce neoplastic transformation. Although in most instances Stat3 is growth-promoting, the impact of cell density on Stat3 activation status and the biological importance of Stat3 during growth arrest have not been characterized. Previous results indicated that cell density alters tyrosine phosphorylation levels of cultured cells. Since signalling through Stat3 is determined by a key phosphorylation at tyr705, we examined the effects of cell density upon Stat3 activity in normal breast epithelial cells, breast carcinoma lines and normal mouse fibroblasts. Intriguingly, the results revealed a dramatic increase in Stat3, tyr705 phosphorylation and activity with cell density, which gradually declined at later stages. This activation was dependent upon cell-cell contact, since it was eliminated if cell adhesion was disrupted through calcium chelation, while it was reinstated through cell aggregation. Furthermore, this activation was suppressed following inhibition of JAKs (Janus kinases) but not inhibition of Fer, IGF1-R, or kinases of the c-Src family. On the other hand, constitutively active Stat3 in carcinoma lines, known to harbor activated Src, was blocked by pharmacological inhibitors of Src as well as JAKs. These results point to the existence of two distinct pathways of Stat3 activation in breast carcinomas, based on Src dependence. More importantly, our results suggest that Stat3 activity is upregulated during the confluence-mediated growth arrest by a signalling mechanism that requires JAKs.

Animals↗
PubMed2004

Successful live cell harvest from bisected sentinel lymph nodes research report.

Sentinel lymph nodes provide an excellent opportunity to study early immune responses to cancer. However, harvesting live cells has not previously been possible, because it conflicts with the need to preserve tissue for histological interpretation. This study used scrape cytology on 26 sentinel and 8 non-sentinel nodes, harvested from 17 stage I/II melanoma patients undergoing sentinel node biopsy. Numbers of viable cells harvested before and after cryopreservation were measured and the effect on subsequent histology assessed. The mean number of cells harvested from 26 sentinel nodes was 7.06 x 10(6) (range 0.1-32.2), with a mean viability of 99.5% (range 87-100, lower 95% CI 98.5%). Furthermore, counts and viabilities were well maintained after cryopreservation. Flow cytometry confirmed CD3+, CD20+ and lineage-1-/HLA-DR+ subpopulations, consistent with T-lymphocytes, B-lymphocytes and dendritic cells, respectively. Importantly, there was no discernible change in histological detail and the proportion of positive sentinel nodes remained unchanged. This technique will allow more functional and quantitative approaches to sentinel lymph node research.

Antigens, CD20↗
PubMed2004

An analysis of the rollover backstroke turn by age-group swimmers.

Kinetic (3-D force plate), kinematic (videography) and temporal characteristics of backstroke turns by 20 male and 16 female swimmers were recorded to identify and describe key elements of backstroke turning performance. Data were recorded during a 50 m maximum effort swim in a 25 metre pool. A Pearson product moment correlation matrix revealed that the 5 m RTT was significantly correlated with anthropometric measures of height, mass, trochanteric height and age; kinetic measures of horizontal impulse and peak force; and kinematic measures of wall contact time and peak velocity. The stepwise multiple regression equation to predict 5 m RTT was: 19.6-0.75 trochanteric height-1.8 wall exit velocity-0.03 peak vertical force. Four key factors were identified from a principle components factor analysis--anthropometry and force, post-turn velocity, force preparation and rotational skills. Implications from the findings were that age-group backstrokers should 'hit the wall hard' with relatively extended legs to reduce swim distance and push-off deceleration; use minimal wall contact time, and maximise forces to develop high horizontal velocities in a streamlined position.

Anthropometry↗
PubMed2004

Melanoma vaccines.

Melanoma vaccines offer new hope to patients with metastatic melanoma, although convincing survival advantages have yet to be reported. This review outlines the progress made in this exciting field of research and looks ahead to the future.

Antigens, Neoplasm↗
PubMed2003

Kinematics used by world class tennis players to produce high-velocity serves.

The purpose of this study was to quantify ranges and speeds of movement, from shoulder external rotation to ball impact, in the tennis service actions of world class players. Two electronically synchronised 200 Hz video cameras were used to record 20 tennis players during singles competition at the Sydney 2000 Olympic games. Three-dimensional motion of 20 landmarks on each player and racquet were manually digitized. Based upon the mean values for this group, the elbow flexed to 104 degrees and the upper arm rotated into 172 degrees of shoulder external rotation as the front knee extended. From this cocked position, there was a rapid sequence of segment rotations. The order of maximum angular velocities was trunk tilt (280 degrees/s), upper torso rotation (870 degrees/s), pelvis rotation (440 degrees/s), elbow extension (1510 degrees/s), wrist flexion (1950 degrees/s), and shoulder internal rotation. Shoulder internal rotation was greater for males (2420 degrees/s) than females (1370 degrees/s), which may be related to the faster ball velocity produced by the males (50.8 m/s) than the females (41.5 m/s). Although both genders produced segment rotations in the same order, maximum upper torso velocity occurred earlier for females (0.075 s before impact) than for males (0.058 s). At impact, the trunk was tilted 48 degrees above horizontal, the arm was abducted 101 degrees and the elbow, wrist, and lead knee were slightly flexed. Male and female players should be trained to develop the kinematics measured in this study in order to produce effective high-velocity serves.

Arm↗
PubMed2003

Growth in body size affects rotational performance in women's gymnastics.

National and state representative female gymnasts (n = 37), aged initially between 10 and 12 years, completed a mixed longitudinal study over 3.3 years, to investigate the effect of body size on gymnastic performance. Subjects were tested at four-monthly intervals on a battery of measures including structural growth, strength and gymnastic performance. The group were divided into 'high growers' and 'low growers' based on height (> 18 cm or < 14 cm/37 months, respectively) and body mass (> 15 kg or < 12 kg/37 months, respectively) for comparative purposes. Development of gymnastic performance was assessed through generic skills (front and back rotations, a twisting jump and a V-sit action) and a vertical jump for maximum height. The results show that the smaller gymnast, with a high strength to mass ratio, has greater potential for performing skills involving whole-body rotations. Larger gymnasts, while able to produce more power and greater angular momentum, could not match the performance of the smaller ones. The magnitude of growth experienced by the gymnast over this period has a varying effect on performance. While some activities were greatly influenced by rapid increases in whole-body moment of inertia (e.g. back rotation), performance on others like the front rotation and vertical jump, appeared partly immune to the physical and mechanical changes associated with growth.

Analysis of Variance↗
PubMed2003

Role of joint torques generated in an optimised Yurchenko layout vault.

The purpose of the study was to quantify the muscle torques required in the performance of an optimised Yurchenko layout vault based on a five-segment rigid link model and using input data from an elite female gymnast. At impact, the wrist torque trajectory indicated an extension-flexion action while the shoulder was characterised by extension. The approximate 100 Nm (wrist flexor) and 125 Nm (shoulder extensor) respective peak torque magnitudes indicated that the impact action is not passive in nature. The contribution of joint torques to the adjoining segments was apportioned to the relative components namely; centripetal, gravity and net joint torque components. Despite the presence of both large wrist and shoulder joint torques, the net turning effect on the upper limb and hand segments about their centre of mass (CM) was small. The principal role of the upper limb joint torques was therefore to effect the appropriate joint motions and to support the weight of the gymnast. The performance of the optimum vault was primarily the result of the interplay between the centripetal and the net joint torque components at the wrist, hip and shoulder joints. This has implications to the performer in that successful execution of the vault is principally concerned with the ability to create a high angular momentum for horse impact and to then apply an appropriate level of joint torques that will make optimal use of the initial kinetic condition.

Algorithms↗
PubMed2003

Accuracy of qualitative analysis for assessment of skilled baseball pitching technique.

Baseball pitching must be performed with correct technique if injuries are to be avoided and performance maximized. High-speed video analysis is accepted as the most accurate and objective method for evaluation of baseball pitching mechanics. The aim of this research was to develop an equivalent qualitative analysis method for use with standard video equipment. A qualitative analysis protocol (QAP) was developed for 24 kinematic variables identified as important to pitching performance. Twenty male baseball pitchers were videotaped using 60 Hz camcorders, and their technique evaluated using the QAP, by two independent raters. Each pitcher was also assessed using a 6-camera 200 Hz Motion Analysis system (MAS). Four QAP variables (22%) showed significant similarity with MAS results. Inter-rater reliability showed agreement on 33% of QAP variables. It was concluded that a complete and accurate profile of an athlete's pitching mechanics cannot be made using the QAP in its current form, but it is possible such simple forms of biomechanical analysis could yield accurate results before 3-D methods become obligatory.

Adolescent↗
PubMed2002

Constitutive activation of met kinase in non-small-cell lung carcinomas correlates with anchorage-independent cell survival.

Lung cancer is currently the most frequent cause of cancer death in North America. Hepatocyte growth factor (HGF) and its receptor Met are frequently over-expressed in non-small-cell lung carcinomas (NSCLC), but their potential role in tumor progression is not clearly known. To assess the role of HGF/Met signaling in lung carcinomas, we have examined the expression, activation status, and function of Met in NSCLC cell lines (n = 7), established from primary tumors or pleural fluids of cancer patients. We observed Met expression in three NSCLC cell lines, two of which exhibited constitutive tyrosine-phosphorylation of Met, and Met kinase activity. In addition, the observed constitutive activation of Met was sustained under anchorage-independent conditions, and correlated with phosphatidyl inositol 3-kinase-dependent cell survival. Immunoreactive HGF-like protein was secreted by two Met-positive and two Met-negative NSCLC cell lines. However HGF activity, as determined by the ability to induce cell scattering and tyrosine-phosphorylation of Met in reporter cell lines, was detected in conditioned medium from only one Met-negative NSCLC cell line: none of the conditioned media from Met-expressing NSCLC cell lines showed detectable HGF activity. Thus, constitutive activation of Met in NSCLC cell lines may occur at least in part through intracrine, or HGF-independent mechanisms. Interestingly, additional paracrine stimulation with exogenous recombinant HGF was required for DNA synthesis and correlated with increased activation of ERK1/2 in all Met-positive NSCLC cell lines, regardless of the basal activation status of Met. These findings indicate that a medium level of constitutive activation of Met occurs in some NSCLC cell lines, and correlates with survival of detached carcinoma cells; whereas additional paracrine stimulation by recombinant HGF is required for DNA synthesis. Thus constitutive and paracrine activation of Met may provide complementary signals that promote survival and proliferation, respectively, during tumor progression of NSCLC.

Animals↗
PubMed2002

Biomechanical analysis of the grab, track and handle swimming starts: an intervention study.

This study examined the grab, track and handle swimming racing starts by elitelevel swimmers. Videography was used to analyse these starts before and after a period of dive start practice. Participants underwent 2-4 sessions weekly until 14 +/- 2 practice sessions were completed. Practice sessions comprised 5 grab starts (preferred technique) and 10 handle starts; or 5 grab starts and 10 track starts. The performance criterion measure was time to 10 m. Reaction, movement, block and flight times, flight distance, and the centre of mass at the set position were measured. No significant differences between dive groups in time to 10 m were revealed pre- or post-training. The training period further exaggerated the differences in centre of mass positions in the set position between the three techniques. The handle start revealed a significant change forward in the centre of mass that allowed for decreased movement and block times. The training period improved 10 m, reaction, movement, block and flight times irrespective of the technique used. Hence, regular dive start practice significantly improved the start performances of elite swimmers. Coaches should consider including regular dive practice sessions of approximately 15 minutes to improve dive start performances.

Adolescent↗
PubMed2002

The one- and two-handed backhands in tennis.

The study investigated differences in the one- (SH) and two-handed (DH) backhands when hit flat, across-court (AC) and down-the-line (DL), and with heavy topspin DL (TDL). The ability to disguise each of these backhands when hitting the above strokes was also assessed. Eighteen college-level male tennis players, identified as having a high performance topspin SH (n = 6) or DH (n = 12) backhand drive, participated in the study. Players were required to hit three AC, DL and TDL backhands from the baseline with their preferred technique, while being filmed with two high-speed video cameras operating at 200 Hz. The highest horizontal velocity backhand for each stroke was analysed. Results indicated that the sequential coordination of five body segments (hips, shoulder, upper arm, forearm, and hand/racquet rotations) was required for the execution of the SH stroke. The same number of segments were generally coordinated in the DH stroke (hips, shoulders, and varying degrees of upper arm and forearm rotations followed by hand/racquet movement). Mature players produced comparable racquet horizontal velocities 0.005 s prior to impact using either the SH or DH backhand technique. The SH backhand was characterised by a more rotated shoulder alignment than the DH stroke (SH: 119.1 degrees; DH: 83.4 degrees) at the completion of the backswing. At impact the ball was impacted further in front (SH: 0.59 m: DH: 0.40 m) and a similar distance to the side of the body (SH: 0.75 m: DH: 0.70 m). Players using the DH backhand technique delayed the horizontal acceleration of the racquet towards the ball (SH: 0.13 s: DH: 0.08 s prior to impact) and thus were capable of displaying a similar hitting motion closer to impact than players with a SH technique.

Adult↗
PubMed2002

The RowPerfect ergometer: a training aid for on-water single scull rowing.

The purpose of this study was to compare rowing technique on the dynamic RowPerfect ergometer with a single scull. Eight national-level rowers performed on both the RowPerfect ergometer and in a single scull over 500 m, at rates of 24, 26, and 28 strokes/minute. Blade force and oar angle (on-water) and handle force and stroke length (on the ergometer) were measured. Both force and stroke angle/length were normalised from 0 to 100 (where 100 was the peak value). Body positions of the subjects at both the catch and finish of each of these rowing strokes were also compared for each stroke rate. The coefficient of multiple determination (CMD) was used to measure the consistency of force curves over a sample of five sequential strokes for each rower. Cross-correlations were performed between the left- and right-side on-water sculling force curves and a mean of these values with the ergometer curve for each rower. Stroke angle/length, which did not vary with rate, was similar for both forms of rowing. The CMDs showed a high consistency across the normalised strokes of each subject (approximately 0.98). Cross-correlation values of 0.91, 0.92, and 0.93 were recorded between the force curves from the ergometer and on-water trials for stroke rates of 24, 26, and 28 strokes/minute, respectively. The mean trunk, thigh and lower leg angles at the catch and finish of the stroke were also similar across the stroke rates as determined by t-tests. Results indicate that technique used on the RowPerfect ergometer was similar to that for on-water sculling, thus validating its use in off-water training.

Adolescent↗