PubMed Health⌕ Search

Biomedical subjects

Bruce Hultgren

Publications and source records attributed to Bruce Hultgren.

2 recordsLinked to original sources

The precision of computer-generated surgical splints.

PURPOSE: The purpose of this study was to assess the precision of stereolithographic surgical splints generated by the authors' computer-aided design and manufacturing (CAD/CAM) technique by comparing them with the conventional acrylic splints. MATERIALS AND METHODS: Seven volunteers were used. A pair of surgical splints, stereolithographic and conventional acrylic splints, was fabricated for each subject. A novel method was developed to quantify the airspace between the teeth and the splint. Conventional acrylic surgical splints served as a control group. The airspaces were recorded by impression materials and sliced cross-sectionally. Corresponding areas of the cross-sectional airspaces between stereolithographic and acrylic splints were measured and compared. Pearson's correlation coefficient and linear regression tests were performed. RESULTS: Seven pairs of surgical splints were created. The areas of 98 pairs of cross-sectional airspaces were measured. The average difference between the conventional and the STL splints was 0.24 +/- 0.23 mm(2). The correlation coefficient (r) of the airspace areas between the stereolithographic and conventional acrylic splints was 1.00, and the regression coefficient (beta) was 1.03 (P <.01). CONCLUSIONS: The results indicated that the stereolithographic splints, generated by the authors' CAD/CAM technique, had a high degree of accuracy. The fit of the STL splints was the same as the conventional surgical splints. In the future, traditional plaster dental model surgery will be replaced by computer-assisted surgical planning. The surgical splints will be made in the computer and the treatment plan will be directly transferred to the patient.

Acrylic Resins↗

Transgenic mice expressing human fibroblast growth factor-19 display increased metabolic rate and decreased adiposity.

The fibroblast growth factors (FGFs), and the corresponding receptors, are implicated in more than just the regulation of epithelial cell proliferation and differentiation. Specifically, FGF23 is a regulator of serum inorganic phosphate levels, and mice deficient in FGF receptor-4 have altered cholesterol metabolism. The recently described FGF19 is unusual in that it is nonmitogenic and appears to interact only with FGF receptor-4. Here, we report that FGF19 transgenic mice had a significant and specific reduction in fat mass that resulted from an increase in energy expenditure. Further, the FGF19 transgenic mice did not become obese or diabetic on a high fat diet. The FGF19 transgenic mice had increased brown adipose tissue mass and decreased liver expression of acetyl coenzyme A carboxylase 2, providing two mechanisms by which FGF19 may increase energy expenditure. Consistent with the reduction in expression of acetyl CoA carboxylase 2, liver triglyceride levels were reduced.

Adipose Tissue↗