Biomedical subjects

Bruno Bouchet

Publications and source records attributed to Bruno Bouchet.

4 recordsLinked to original sources

PubMed2006

Antithrombin supplementation for anticoagulation during continuous hemofiltration in critically ill patients with septic shock: a case-control study.

INTRODUCTION: Acquired antithrombin III (AT) deficiency may induce heparin resistance and premature membrane clotting during continuous renal replacement therapy (CRRT). The purpose of this study was to evaluate the effect of AT supplementation on filter lifespan in critically ill patients with septic shock requiring CRRT. METHODS: We conducted a retrospective case-control analysis based on a 4-year observational study with prospectively collected data in two medical intensive care units in a university hospital. In all, 106 patients with septic shock underwent CRRT during the study period (55 during 2001 to 2002 and 51 during 2003 to 2004). Of these, 78 had acquired AT deficiency (plasma level below 70%) at onset of renal supportive therapy, 40 in the first 2-year period and 38 in the last 2-year period. In the latter intervention period, patients received AT supplementation (50 IU/kg) during CRRT each time that plasma AT activity, measured once daily, fell below 70%. RESULTS: In a case-control analysis of the 78 patients with acquired AT deficiency, groups were similar for baseline characteristics, except in severity of illness as assessed by a higher Simplified Acute Physiology Score (SAPS) II after 2002. In comparison with controls, cases had a significantly greater AT level after AT supplementation, but not at baseline, and a smaller number of episodes of clots, without excess bleeding risk. The median hemofilter survival time was longer in the AT group than in the heparin group (44.5 versus 33.4 hours; p = 0.0045). The hemofiltration dose, assessed by the ratio of delivered to prescribed ultrafiltration, increased during intervention. AT supplementation was independently associated with a decrease in clotting rate, whereas femoral angioaccess and higher SAPS II were independent predictors of filter failure. However, mortality did not differ between periods, in the control period the observed mortality was significantly higher than predicted by the SAPS II score, unlike in the treatment period. CONCLUSION: In sepsis patients requiring CRRT and with acquired AT deficiency, anticoagulation with unfractionated heparin plus AT supplementation prevent premature filter clotting and may contribute to improving outcome, but the cost-effectiveness of AT remains to be determined.

Adult↗

PubMed2005

The attributable mortality of acute renal failure in critically ill patients with liver cirrhosis.

OBJECTIVE: To determine outcome and mortality risk related to acute renal failure (ARF) in critically ill patients with cirrhosis. DESIGN AND SETTING: A retrospective cohort analysis and two independent case-control analyses in a medical ICU. PATIENTS: 41 and 32 patients who developed mild and severe ARF, respectively, matched (1:2 ratio) with cirrhotic patients without ARF during their ICU stay. MEASUREMENTS AND RESULTS: Cirrhotic patients with ARF had higher MELD, APACHE II, and SOFA scores at baseline that those without ARF. They had more respiratory failure and cardiovascular failure during ICU stay, longer stay in ICU, and a greater crude hospital mortality rate (65% vs. 32%). Multivariate survival analysis identified ARF (hazard ratio, HR, 4.1), alcohol abuse or dependency, and severe sepsis or septic shock as independent predictors of death. In case-control studies both mild and severe ARF were independently associated with mortality (HR, 2.6, and 4.2, respectively). Cirrhotic patients with mild ARF patients had a higher risk of death than those without ARF (relative risk, RR, 2.0). Severe ARF was associated with an increase matched risk of death (RR 2.6), higher mortality of 51%, and higher risk-adjusted mortality rate (2.1 vs. 0.9). CONCLUSIONS: ICU patients with liver cirrhosis still have a high crude mortality. In this specific population ARF is associated with an excess mortality, depending on the severity of renal dysfunction.

Acute Kidney Injury↗

PubMed2002

The evaluation of quality assurance: developing and testing practical methods for managers.

OBJECTIVE OF THE STUDY: To develop an approach for evaluating quality assurance (QA) activities and programs in health care settings and to test different evaluation methods. DESIGN: This was not a formal scientific study, but rather a research and development (R&D) study, which followed the following steps: (1) reviewing the literature; (2) clarifying critical issues for all key aspects of QA activities; (3) drafting a guide to provide a flexible vehicle for different approaches; (4) testing and adapting the guide as it evolved in three countries; and (5) testing two evaluation tools (self-assessment and appreciative evaluation) in Chile. SETTING AND STUDY PARTICIPANTS: The evaluation guide was tested by evaluating QA structures, activities, and programs at the country, regional, and facility levels in Zambia, Niger, and Chile. RESULTS: The study resulted in an evaluation guide, which includes an implementation outline, an evaluation matrix, and an appendix of evaluation tools and methods. The guide helps evaluators: agree on a proposed evaluation's scope and design; develop an evaluation methods plan; and address QA history, advocacy, culture, and structure, as well as QA activities and accomplishments. Specific results of the country evaluations in Zambia, Niger, and Chile are presented in separate articles in this supplement. CONCLUSION: The QA programs in which the evaluation guide was tested differed in many ways, such as health system structure, decision to focus on particular services, political level implementing QA, policy environment, leadership, and program evolution. The implementation guide presents an outline of the key implementation steps for an evaluation, and includes checklists and model forms (e.g. sample agenda for a team planning meeting, sample list of questions to focus the evaluation). The evaluation matrix presents indicators by QA component and key question, and it enables evaluators to build an approach and select methods. The appendix describes the various tools and methods presented in the first two sections of the evaluation guide.

Chile↗

PubMed2002

The Zambia quality assurance program: successes and challenges.

OBJECTIVES: The objectives of the evaluation were to review the performance of the Zambia Quality Assurance Program (ZQAP) and provide recommendations to help design its next phase. DESIGN AND METHODS: Topics for evaluation were identified from a systems analysis of what an 'ideal' quality assurance (QA) program might look like. The evaluation team was made up of six experts who developed questionnaires to guide the interviews and related scoring tools. The evaluation team visited 24 health facilities in nine districts, representing all four regions of Zambia, and interviewed 140 persons, including health personnel from the public and private sectors, and non-health personnel. FINDINGS: In 5 years, senior staff built a QA structure and capacity throughout Zambia, generated enthusiasm for QA, and initiated teamwork on quality of care issues by motivated health staff. Some challenges remain: lack of integration of QA, uncoordinated standards, weak methods of standards communication, poor measurement of compliance with clinical care standards, constraints on the work of the quality improvement teams, and inconsistent support systems. RECOMMENDATIONS: The evaluation team made recommendations regarding a national QA policy, mechanisms to develop standards of care, monitoring of health providers' performance, needs of quality improvement teams, training in QA, and documentation of QA activities. CONCLUSIONS: Despite its success in covering the entire country with a network of QA coaches and trainers, the capacity of the public sector to sustain QA activities at the central and district levels remains a challenge. Lessons from the Zambia experience can benefit QA programs in other developing countries.

Developing Countries↗