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Biomedical subjects

C A Bach

Publications and source records attributed to C A Bach.

9 recordsLinked to original sources
PubMed1999

High-performance liquid chromatographic analysis of the D4 receptor antagonist SCH 66712 in rat plasma.

SCH 66712 is a potent and selective dopamine D4 receptor antagonist. An HPLC method was developed for the analysis of SCH 66712 in the plasma of rats, a species used for safety evaluation of this compound. The method involved solid-phase extraction on an ethyl cartridge and HPLC separation on a reversed-phase C8 column with quantitation using a fluorescence detector. The calibration curve was linear over a concentration range of 5-100 ng/ml. The limit of quantitation was 5 ng/ml, where the coefficient of variation (C.V.) was 2.9% and the bias was 6%. The precision of the method was satisfactory as indicated by an intra-day C.V. of < or = 4% and an inter-day C.V. of < or = 6%. The accuracy was also satisfactory as shown by an intra-day bias of < or = 8% and an inter-day bias of < or = 9%. The assay was shown to be sensitive, specific, accurate, precise, and reliable for use in pharmacokinetic or toxicokinetic studies.

Animals↗
PubMedDate not supplied

Traveling with technology.

This article reports on a 2-week trip in a motor home through the southeastern United States with an oxygen- and ventilator-dependent young woman with muscular dystrophy. The article describes the planning, implementation, and evaluation of traveling with technology. Discussed are the amount and types of equipment and supplies to take on such a trip, modification of equipment and the motor home, the roles and responsibilities of the nurses, interactions with the client and family, and legal issues. The impact of the trip on the client's behavior--which was to transform her from a passive recipient of care to an actively involved participant--is reported.

Adult↗
PubMedDate not supplied

Quality of life in quadriplegic adults: a focus group study.

This article describes a study whose purpose was to provide additional information about the components of quality of life for quadriplegic individuals. A focus group technique was used to determine subjects' opinions about what constitutes an acceptable quality of life. Three focus groups with a total of 14 subjects met to discuss the topic. Transcripts of the interviews were analyzed to determine themes and to identify components of quality of life for these individuals. Findings indicate that the factors influencing quality of life for quadriplegics include inner strength/survival, finances, relationships, job/productivity, health, level of activity, assertiveness, and independence/dependence. These findings will provide health professionals and policymakers with information about what factors quadriplegics consider important to maintaining an acceptable quality of life. This knowledge is necessary for public policy development, resource allocation, and interventions that will enhance the quality of life for people affected by quadriplegia.

Activities of Daily Living↗
PubMedDate not supplied

Concept analysis of outcomes for advanced practice nursing.

The importance of accurately measuring health care outcomes is mentioned frequently in the literature. To do so, a common understanding of what constitutes a care delivery outcome is needed. In this article, a concept analysis of outcomes is provided, with identification of potential outcomes relevant to advanced practice.

Health Promotion↗
PubMedDate not supplied

Nursing research. Making it easier.

Conducting nursing research, whether to fulfill a requirement for a graduate degree or to satisfy professional curiosity, often is frustrating for the novice researcher. This article presents strategies that can be used by staff development educators to assist nurse researchers in conducting research more efficiently.

Humans↗
PubMedDate not supplied

Posters: innovative and cost-effective tools for staff development.

Nursing staff development educators can use the poster as a time- and cost-effective means to present essential information about policies and procedures as well as current, pertinent information about research findings. In this article, the authors present guidelines for preparation of successful poster presentations.

Audiovisual Aids↗