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Biomedical subjects

C A Dennis

Publications and source records attributed to C A Dennis.

7 recordsLinked to original sources
PubMed1976

Low density and high density lipoprotein turnover following portacaval shunt in swine.

Turnover of 125I-low density lipoprotein (LDL) and of 131I-high density lipoprotein (HDL) was determined before and after end-to-side portacaval shunt in eight swine. LDL (d 1.019-1.063) and HDL (d.1.09-1.21) were isolated by ultracentrifugation and iodinated by the iodine monochloride technique. Immediately postoperatively there was no consistent change in the fractional catabolic rate (FCR) of LDL compared to preoperative control values, while in all animals FCR of HDL was significantly increased (by as much as 300%). After recovery from surgery, neither LDL nor HDL catabolic rates were significantly elevated above control values in four swine. However, plasma levels of LDL and HDL protein, and of LDL and HDL cholesterol were significantly reduced 10-12 weeks after the portacaval shunt. The reduced levels of LDL and HDL associated with normal fractional clearance rates imply a reduction in synthesis of LDL and HDL following portal diversion.

Animals↗
PubMed1975

Mercury levels in whole blood of Saskatchewan residents.

The study was undertaken to establish whole blood mercury levels in the Saskatchewan population and to identify characteristics of individuals with higher blood levels. The mean blood mercury level was 6.7 ng/ml, the median level 5 ng/ml and the range 1 to 42 ng/ml. Native persons living in northern Saskatchewan who had recently eaten local fresh-water fish had the higher levels. A greater consumption of fish and higher blood mercury levels were recorded during the fresh-water fishing season.

Adolescent↗
PubMed1975

The relationship between mercury levels in maternal and cord blood.

The object of the study was to discover the relationship between mercury levels in maternal and cord blood. Paired whole blood samples, maternal and cord blood were analysed for total mercury content; 45 paired samples from non-fish-eating women in southern Saskatchewan demonstrated no significant differences in mercury levels between maternal and cord blood; 43 paired samples from fish-eating women in northern Saskatchewan demonstrated a significant difference, cord blood levels being higher. The significant is discussed.

Animals↗