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Biomedical subjects

C A GORESKY

Publications and source records attributed to C A GORESKY.

9 recordsLinked to original sources
PubMed1965

THE HEPATIC UPTAKE AND EXCRETION OF SULFOBROMOPHTHALEIN AND BILIRUBIN.

Experimental evidence bearing on the hepatic uptake and excretion of sulfobromophthalein and bilirubin is considered. From this examination it is postulated that the hepatic handling of each compound consists of three steps: the uptake at the sinusoidal surface of the parenchymal cell by a concentrative membrane transport system of high capacity; the conjugation within the cell with glutathione and glucuronic acid, respectively; and the excretion into the biliary canaliculus of the respective conjugates by a second concentrative system of relatively low capacity. Two of the operating characteristics of this linked system, the easy attainment of saturation of the biliary excretory transport system and the presence of an intracellular storage phenomenon, have been shown to result from the disproportionate capacities of the two sequentially placed concentrative membrane transport systems. The disorders which may occur in the three steps underlying the handling of each of these compounds are also considered.

Bilirubin↗
PubMed1965

THE NATURE OF TRANSCAPILLARY EXCHANGE IN THE LIVER.

The nature of transcapillary exchange in the liver was explored by applying the single-injection multiple-indicator dilution technique to the liver. Labelled red cells and a group of passively distributed substances were introduced into the portal vein in the dog. The diffusible substances were delayed during their passage through the liver and the outflow pattern produced by the delay was found, in each case, to correspond to that situation in which the diffusion of these substances across the sinusoidal wall was so rapid in relation to flow that it could be considered complete at every point along the length, a situation which may be termed flow-limited. The calculated volume of distribution for water corresponded to the actual water volume in the excised liver. The volume of distribution for the extracellular diffusible substances was shown to decrease with increase in molecular weight.

Animals↗
PubMed1964

RENAL FAILURE IN CIRRHOSIS OF THE LIVER.

The clinical course and autopsy findings of three patients with acute renal failure terminating the course of cirrhosis of the liver are presented. Review of the literature demonstrated that where decompensated cirrhosis is present the renal blood flow is characteristically low, although the total cardiac output is elevated. This circulatory disturbance results in the production of urine low in sodium, although normal in solute content. It also renders the kidney more vulnerable to further, sometimes minor, reductions in renal blood flow. As more patients with hepatic cirrhosis live through episodes of gastrointestinal bleeding and hepatic coma, death in acute renal failure will undoubtedly become more common.

Acute Kidney Injury↗