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Biomedical subjects

C A Greene

Publications and source records attributed to C A Greene.

At least 19 recordsLinked to original sources
PubMed1998

Abnormalities for chromosomes 13 and 21 detected in spermatozoa from infertile men.

Sperm samples from infertile men with oligozoospermia or teratozoospermia were studied by multicolour fluorescence in-situ hybridization (FISH) using DNA probes for chromosomes 13 and 21. A total of 90 809 sperm nuclei from nine infertile men and 182 799 sperm nuclei from 18 control donors were analysed. There was a highly significant increase in the frequency of spermatozoa disomic for chromosome 13 in infertile patients (0.28%) compared to control donors (0.13%) (two-tailed Z statistic P < 0.0001) and for chromosome 21 (0.48% in infertile men versus 0.37% in controls, P < 0.0001). Also there was a significantly increased frequency of diploid spermatozoa in infertile men (0.85%) compared to control donors (0.66%) (P < 0.0001). Our previous studies on these same infertile patients demonstrated increased frequencies of sperm disomy for chromosomes 1 and XY. This suggests that infertile men, who are prime candidates for intracytoplasmic sperm injection, may be at a very small increased risk of aneuploid offspring.

Adult↗
PubMed1995

Falloposcopic cannulation, oviductal appearances and prediction of treatment independent intrauterine pregnancy.

The purpose of this study was to determine whether there is an association between the appearance of the oviductal lumen during falloposcopic examination, and the occurrence of intrauterine pregnancy or ectopic pregnancy independent of treatment. Sixty-two consecutive women were recruited who were examined falloposcopically in-office, and who did not require subsequent surgical intervention to restore tubal patency. There was a heterogeneous group of presentations including unilateral and bilateral proximal tubal occlusion, unexplained infertility and the presence of minor laparoscopic abnormalities which might suggest the possibility of occult endotubal pathology. A stepwise Cox's model of life table analysis selected the number of falloposcopically normal and patent Fallopian tubes as the only variable significantly associated with intrauterine pregnancy, when all clinical, demographic and investigative data were analysed. The presence of minor distal intra-tubal adhesions was selected on stepwise analysis as the only variable significantly associated with the occurrence of ectopic pregnancy. A number of falloposcopic abnormalities were significantly associated with outcome in the clinical sub-group who presented with bilateral proximal tubal occlusion. These data suggest that falloposcopy is a valuable clinical tool which provides useful prognostic data for the prediction of intrauterine pregnancy or ectopic pregnancy.

Adult↗
PubMed1995

Human embryo implantation following in-vitro fertilization: is there a seasonal variation?

The purpose of this study was to determine whether there is a seasonal variation in implantation and pregnancy rates following natural cycle replacement of cryopreserved embryos. A total of 321 consecutive cycles were analysed. There were 59 pregnancies (18.4%) and 48 live births or ongoing pregnancies (15.0%). Indicator variables for each month and variables representing temporal cycles of 12, 6, 4, 3 and 2 months were related to outcome. In addition, an analysis of periodicity was performed. No temporal, clinical or demographic variable was significantly related to pregnancy. This study indicated that there was no clear seasonal variation in the pregnancy rate following natural cycle replacement. However, the power of this study was low, and it was estimated that 963 subjects would be required to detect a 10% seasonal difference in pregnancy rates.

Adult↗
PubMed1995

The bidirectional relationship between achievement and externalizing behavior problems of students with learning disabilities.

The current study examined the bidirectional relationship between academic achievement and externalizing behavior problems of adolescents with learning disabilities. Forty-three students attending a residential school were assessed for externalizing behavior problems via parent and teacher reports on the Child Behavior Checklist and the Children's Attention and Adjustment Survey. The Wide Range Achievement Test-Revised was used to estimate academic achievement in reading, spelling, and arithmetic. Achievement measures did not predict externalizing behavior problems 1 to 2 years later, although verbal IQ predicted parent reports. Teacher reports of externalizing behavior problems predicted reading and spelling achievement scores 1 year later, and parent reports of externalizing behavior problems predicted changes in reading achievement. There was evidence that attentional problems were the component of externalizing behavior accounting for these relations, consistent with the explanation that inattentive students have difficulty achieving in an intensive learning environment.

Adolescent↗
PubMed1993

"Superimposition" digital subtraction angiography: evaluation of total anomalous pulmonary venous connection.

Total anomalous pulmonary venous connection (TAPVC) has a relatively high surgical mortality, especially the infracardiac variety. A small left atrium may limit postoperative cardiac output. Superimposition of digitally subtracted angiographic (DSA) images may be used to define pulmonary venous anatomy, left atrial size, and its spatial relationship to the common pulmonary vein. The technique for acquiring superimposed digitally subtracted images and the results of two cases with infracardiac TAPVC are presented. We have found that this superimposition technique is easily performed and may provide important preoperative information in infants with TAPVC.

Angiography, Digital Subtraction↗
PubMed1992

Exogenous control of the cycle simplifies thawed embryo transfer and results in a pregnancy rate similar to that for natural cycles.

To determine if a satisfactory PR could be achieved in thawed ET using a simplified protocol, standard monitoring in the natural cycle was compared with a controlled preparation of the endometrium with exogenous E2 and P without hormonal or ultrasonographic monitoring. All patients had normal ovarian function, and no GnRH-a were administered. Pregnancy rates, ongoing PRs, and embryo implantation rates were similar in the two groups. The use of exogenous E2 and P without GnRH-a suppression to control the cycle for thaw ET is safe, convenient, and results in PRs at least as good as in the natural cycle. It may be of particular value in patients with an irregular cycle or in those for whom prolonged monitoring is undesirable.

Cryopreservation↗
PubMed1991

The utility of transesophageal echocardiography during and after Fontan operations in small children.

Transesophageal echocardiography with Doppler examination was performed intraoperatively in 19 children undergoing modified Fontan operations and in 10 patients postoperatively. Comparisons were made with results of intraoperative epicardial imaging (9 patients) and with postoperative transthoracic imaging (10 patients). Transesophageal echocardiography optimally visualized atriopulmonary and cavopulmonary anastomoses. Epicardial echocardiography was successful in only three of nine patients. Intraoperative transesophageal echocardiography showed residua in 8 of 19 studies and led directly to surgical revision or medical therapy. These residua included stenosis of the cavopulmonary anastomosis (1 patient), unsatisfactory atrial fenestration (2 patients), patent ductus arteriosus (1 patient), residual cavoatrial shunting (1 patient), atrial thrombi (1 patient), and poor ventricular function (2 patients). Results of examination in the postoperative intensive care unit showed significant abnormalities in 4 of 10 patients. This study demonstrates that transesophageal echocardiography provides unique anatomic and physiologic information during and after modified Fontan operations in small children and therefore may have significant impact on patient management.

Child↗
PubMed1991

Successful catheter fulguration of the His bundle in a postoperative Mustard patient after unsuccessful fulguration of ectopic atrial foci.

Incessant supraventricular tachycardia (SVT) resistant to pharmacological agents may cause cardiac dysfunction requiring more aggressive therapy. We present the case of a 12-year-old postoperative Mustard patient who developed biventricular heart failure due to an atrial ectopic tachycardia resistant to amiodarone. Using endocavitary direct current fulguration techniques, catheter ablation of the His bundle was successfully performed after unsuccessful attempts at ablation of the ectopic atrial foci. After placement of a permanent transvenous rate responsive ventricular pacemaker, the patient's clinical status and cardiac function improved. Endocavitary fulguration of the His bundle is technically feasible after the Mustard procedure and should be considered for treatment of selective cases of pharmacologically resistant SVT.

Amiodarone↗
PubMed1979

The management of the hyperactive child: an overview.

Hyperkinesis has been increasingly recognized as a medical problem of great significance in everyday practice. Not infrequently, a child has been labeled hyperkinetic at an early age, with a battery of tests, psychological evaluations and multiple medications, in addition to the family frustration and anxiety that follow the diagnosis of hyperkinesis of the offspring.

Behavior Therapy↗