PubMed Health⌕ Search

Biomedical subjects

C A Janicki

Publications and source records attributed to C A Janicki.

10 recordsLinked to original sources
PubMed1981

Xilobam: analysis, determination of decomposition products, and assessment of stability.

A stability-indicating UV assay was developed for xilobam, a member of a new class of CNS agents. The method was specific, precise, and accurate. TLC and high-pressure liquid chromatography were used to support method specificity. Xilobam is sensitive to heat, moisture, and basic conditions. The degradation products were identified as N-methylpyrrolidone, 2,6-dimethylaniline, and N,N'-bis(2,6-dimethyl-phenyl)urea. At high temperatures, the incorporation of molecular sieves into glass bottles of xilobam tablets was effective in preventing decomposition caused by moisture or volatile decomposition products.

Chromatography, High Pressure Liquid↗
PubMed1980

Stability-indicating assay for tolmetin sodium in solid dosage forms.

A spectrophotometric assay for determining tolmetin sodium in pharmaceutical solid dosage forms is described. Tolmetin sodium is separated from common pharmaceutical excipients and probable degradation products. Recovery, precision, and accuracy data are provided. Two TLC methods are included which can be used to monitor qualitatively the stability of aged dosage forms.

Chromatography, Thin Layer↗
PubMed1980

High-performance liquid chromatographic assay of codeine in acetaminophen with codeine dosage forms.

An accurate, rapid, and specific high-performance liquid chromatographic (HPLC) assay was developed for codeine in acetaminophen with codeine combination products. The internal standard (chlorpheniramine maleate), codeine, acetaminophen, and several other test compounds or impurities were well separated. A complete analysis took < 10 min. The relative standard deviations of the retention time, precision, and accuracy were 0.5, 0.4, and 0.5%, respectively. An excellent linear correlation was obtained between the HPLC and GLC methods.

Acetaminophen↗
PubMed1975

High-pressure liquid chromatographic determination of propoxyphene hydrochloride in tablets and capsules.

The determination of propoxyphene hydrochloride by gas chromatography (GC) has been examined. Under a number of operating conditions significant on-column decomposition has occurred. The amounts of decomposition have been found to be dependent on sample size, flow-rate, column temperature, liquid phase loading, and solid support material. In view of this work a high-pressure liquid chromatographic procedure for quantitating propoxyphene hydrochloride has been developed. This method has been found to be specific for propoxyphene hydrochloride in the presence of its heat decomposition products formed with and without acetaminophen. This method does not suffer from problems associated with GC procedures.

Capsules↗