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Biomedical subjects

C A MacGregor

Publications and source records attributed to C A MacGregor.

4 recordsLinked to original sources
PubMed2005

A randomised double-blind controlled trial of oral soy supplements versus placebo for treatment of menopausal symptoms in patients with early breast cancer.

Menopausal symptoms are a major survivorship issue for patients treated for breast cancer. There are increasing concerns over the use of hormone replacement therapy (HRT) in this setting and a growing consumer interest in "natural" therapies. It had been suggested that soy phyto-oestrogens might be beneficial in the treatment of menopausal symptoms. Seventy-two patients with a histologically confirmed pre-existing diagnosis of breast cancer who were having menopausal symptoms were randomised between 12 weeks of treatment with soy capsules or placebo. Quality of life and menopausal symptom scores were assessed at baseline, 4, 8 and 12 weeks. There was no statistical difference in menopausal symptom scores or quality of life between the two arms of the study.

Adult↗
PubMed1996

Hypothalamic and plasma total nitrate/nitrite concentrations in spontaneously hypertensive rats.

Stable end-products of nitric oxide (NO) metabolism, nitrates and nitrites, were measured in hypothalamic extracts and plasma samples of Okamoto spontaneously hypertensive (SH) rats. The mean total nitrate/nitrite concentration was significantly lower in the hypothalami of SH rats compared with the normotensive Wistar Kyoto (WKY) control animals (P < 0.01). In contrast, their plasma concentrations were significantly higher (P < 0.05). These results indicate that the hypertensive state in SH rats is associated with a diminished production of hypothalamic NO, while the raised plasma nitrate/nitrite levels could reflect an increased compensatory endothelial NO synthase activity in these animals compared with the WKY controls.

Animals↗
PubMed1983

Effect of dietary concentration of total nonstructural carbohydrate on energy and nitrogen metabolism and milk production of dairy cows.

Two complete blended diets with a ratio of concentrate: silage dry matter of 60:40 were fed to 12 Holstein cows in the first 12 wk of lactation in an incomplete changeover arrangement of treatments. Diets differed (dry basis) in content of total nonstructural carbohydrate (24.9% versus 32.9%), neutral detergent fiber (37.0% versus 32.1%), and hemicellulose (19.6% versus 15.7%) but were similar in amounts of lignin, crude protein, soluble nitrogen, and acid detergent insoluble nitrogen. The diet with more total nonstructural carbohydrate was associated with greater dry matter intake as a percentage of body weight and greater yields of milk and solids-not-fat. Cellulose digestibility and mean rumen ammonia concentration were lower with this diet. Despite similar protein solubilities, the diet with more total nonstructural carbohydrate contained more rumen degradable nitrogen (80% versus 60%) but similar amounts of rumen degradable dry matter (82% versus 79%). The metabolizable energy of this diet was used more efficiently for the combined functions of maintenance and production, and net energy for lactation was larger (2.2 versus 1.9 Mcal/kg dry matter), as measured calorimetrically.

Ammonia↗