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Biomedical subjects

C A Macleod

Publications and source records attributed to C A Macleod.

14 recordsLinked to original sources
PubMed1999

Malignant fibrous histiocytoma of the trachea.

Primary tracheal sarcomas are rare. Only 23 cases have previously been reported in the English literature. The present case describes a 72-year-old woman with a malignant fibrous histiocytoma of the trachea. She underwent an endoscopic resection followed by radiotherapy and is well at 12 months follow up. Other cases are reviewed. Tracheal resection is the standard care. However, local resection with postoperative radiotherapy remains an option. Adjuvant chemotherapy may improve local control. Long-term survival has been documented.

Aged↗
PubMed1994

Haemophilus influenzae: the efficiency of reporting invasive disease in England and Wales.

This study compares the efficiency of a special regional survey with routine laboratory reporting to measure the incidence of invasive disease caused by Haemophilus influenzae before routine immunisation against type b strains was introduced. Incomplete reporting does not prevent the monitoring of trends, but it becomes important if the level of underreporting changes with time. This study illustrates the importance of assessing the quality of surveillance data before using them to inform policy or evaluate intervention. Underreporting to the regional survey was found to be 17% and underreporting to the Public Health Laboratory Service (PHLS) Communicable Disease Surveillance Centre (CDSC) was 24%. In response to this study a system has been set up to send reference laboratories a weekly list of reports to CDSC. Manual cross checking helps to complete the ascertainment of cases. All isolates of H. influenzae from cases of invasive disease should be sent to the reference laboratories for serotyping as well as being reported to CDSC.

Bacterial Capsules↗
PubMed1975

Cardia venous blood flow in atrial pacing versus exercise-induced angina pectoris.

Thirteen patients with angina pectoris underwent measurements of great cardiac vein blood flow at rest, with the onset of angina pectoris induced by atrial pacing, and again during angina pectoris induced by exercise in order to compare the regional coronary blood flow response to differing myocardial stresses. All patients had significant obstructions of the left anterior descending artery. Exercise-induced angina, compared to pacing-induced angina, was associated with a higher systolic pressure, higher left ventricular end-diastolic pressure, and a lower heart rate. Indices of myocardial oxygen demand, that is, the systolic pressure-heart rate product and the tension-time index, increased to a similar degree during both types of myocardial stress and great cardiac vein blood flow paralleled these changes. We conclude that in a given patient the level of regional coronary blood flow is similar at the onset of either pacing- or exercise-induced angina, despite significant differences in the hemodynamic response to these myocardial stresses.

Adult↗
PubMedDate not supplied

Measuring outcome of diabetes: a retrospective survey.

The feasibility of using hospital discharge data to monitor six outcome indicators for diabetes care was assessed by reviewing retrospectively the occurrence of these events recorded in hospital records. The population studied was that of the Orkney Islands (19,500) over a 10-year period (1976-1985). During that time, 230 Orkney diabetic patients were treated in Orkney and/or Aberdeen hospitals. The six outcome indicators were: hospital admission rates for diabetic patients (609 in 230 patients), hospital admission rates specifically for diabetic ketoacidosis (29 in 20 patients), rates of diabetes-related lower limb amputations (36 in 23 patients), perinatal mortality rates related to maternal diabetes (nil), visual loss or blindness (13 eyes in 9 patients) and end-stage renal failure (one patient). Scottish Morbidity Returns (which collect data similar to that in the Hospital In-patient Enquiry in England) were shown by case note review to underestimate these outcomes by 41%. Cardiovascular disease, cerebrovascular disease, and peripheral vascular disease accounted for half of all in-patient bed use by diabetic patients (6077 of 13,951 days). The routinely available Scottish hospital discharge data, which are collected for a different purpose, are not sufficiently accurate or complete to reflect variations in actual diabetic events.

Amputation, Surgical↗