Biomedical subjects

C A Matthew

Publications and source records attributed to C A Matthew.

4 recordsLinked to original sources

PubMed1992

Biocompatibility of particulate polymethylmethacrylate bone cements: a comparative study in vitro and in vivo.

The biocompatibility of particles of four different commercial polymethylmethacrylate (PMMA) bone cements was evaluated by exposing human synovial fibroblasts and mouse peritoneal macrophages to particles of cement. Cell integrity and inflammatory potential were assessed using enzyme release and microscopical examination. Results suggested the occurrence of cell damage in both cell types and macrophage studies indicated inflammatory potential. The response in vivo was investigated by intra-articular injection of the particles into mouse knee joints. Clinical and histological evaluation was performed over 2-52 wk. Particles of all four cements were well tolerated in the joints.

Acetylglucosaminidase↗

PubMed1991

Regeneration of rat extensor digitorum longus tendon: the effect of a sequential partial tenotomy on collagen fibril formation.

Alterations in collagen fibril diameter distribution were measured in rat extensor tendons subsequent to two-successive partial tenotomies, 30 days apart. Subsequent to surgery three areas were created. The primary lesion area, consisted of a regenerating window in the central half of the tissue. Secondary lesion areas consisted of strips at the lateral margin of the tissue, removed during the second operation. Between the lesion areas were the non-lesion areas consisting of tissue not removed during surgery. Tissue was examined 40, 60, 120 and 240 days after the initial operation. Within each group, primary and secondary lesion areas remained unimodal in collagen fibril diameter distribution throughout the period of the study. This distribution was initially unimodal in the non-lesion areas but became multimodal by 240 days postoperatively. Both the primary lesion area and non-lesion areas exhibited an increase in frequency of small diameter fibrils between 40 and 60 days postoperatively. It is suggested that all observations may be related to the level of applied stress.

Animals↗

PubMed1991

Collagen fibril morphometry in transected rat extensor tendons.

The regenerative potential of completely transected tendon has been assessed in rat extensor tendon. Collagen fibril diameter distributions were calculated within the gap region of the healing tissue at 10, 30, 60, 120 and 240 days postoperatively. At each age the distribution was found to be unimodal with no indication of any return of bimodality. These results suggest that mechanical stimuli may be a controlling factor in determining fibril diameters and that mature tendon may be unable to reproduce a bimodal collagen fibril diameter distribution subsequent to trauma.

Animals↗

PubMed1987

Numbers of myonuclei and satellite cell nuclei in latissimus dorsi muscles of the chicken.

In the 3-, 33- and 66-day-old chicken, two muscles, the oxidative slow tonic anterior latissimus dorsi and the glycolytic fast twitch posterior latissimus dorsi were compared by the measurement of muscle fibre diameter and the fraction of total muscle tissue nuclei which were either myonuclei or satellite cell nuclei. Between 3 and 33 days there was a period of rapid growth (more marked in the posterior latissimus dorsi) which coincided with a sharp fall in numerical density of myonuclei and satellite cell nuclei (number per cubic millimetre muscle tissue). The fraction of all nuclei which were satellite cell nuclei declined steadily. The higher levels of myonuclei and satellite cell nuclei in the anterior latissimus dorsi were thought to be a reflection of its oxidative metabolism and the presence of multiple endplates. The volume of sarcoplasm occupied by single myonuclei in anterior and posterior latissimus dorsi muscles was shown to be considerably greater than that occupied by nuclei in other cell systems.

Aging↗