NMS-Like syndrome with a lithium/doxepin combination.
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Depression↗
Biomedical subjects
C A Pearlman
Publications and source records attributed to C A Pearlman.
Neuroleptic malignant syndrome: a review of the literature.
The neuroleptic malignant syndrome (NMS) involves fever, extrapyramidal rigidity, and disturbances of autonomic function and consciousness. It occurs more often with high potency and depot forms, frequently 3 to 9 days after initiation and sometimes years later, and is not related to dose or previous exposure. About 40% of cases had evidence of an affective disorder. NMS apparently results from deficient compensatory mechanisms following blockade of dopaminergic regulation of muscle tone and autonomic function. Possible indicators of vulnerability and various treatments are discussed. Neuroleptic challenge resulted in recurrence of symptoms in about one third of cases. Symptoms sometimes subsided despite continued treatment. Early diagnosis and effective treatment have reduced the risk of such challenge.
Adolescent↗
Interference with taste familiarization by several drugs in rats.
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Animals↗
REM sleep and adaptation of psychiatric patients: an application of sleep studies.
The authors used sleep laboratory data to predict responses to psychiatric treatment. The predictions were based on the assumptions that REM latency reflects the need for dreaming and therefore the need for adaptation and that REM time reflects the capacity for the adaptive work associated with REM sleep. Dream recall and dream content were considered indicators of psychological mindedness and the patient's current conflicts. With this material, statistically significant predictions of such outcomes as good response to psychotherapy, elopement, or need for medication were made. The results of this study support the hypothesis that REM sleep is involved in adaptation.
Adaptation, Psychological↗