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Biomedical subjects

C A Pedersen

Publications and source records attributed to C A Pedersen.

94 records · Page 6Linked to original sources
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Thyroid and adrenal measures during late pregnancy and the puerperium in women who have been major depressed or who become dysphoric postpartum.

Prior studies of thyroid, adrenal and mood measures during pregnancy and the puerperium, which we review, have not examined hormone-mood relationships over the full peripartum period during which hormone levels change nor have they compared prior depression history with hormone changes. In a pilot study we measured thyroid and adrenal hormones as well as mood at 38 weeks of pregnancy, and 1, 3, 6, 9 and 12 weeks postpartum in 12 women with major depression history and 14 women with negative psychiatric history. Subjects with prior depressions had significantly higher T3, T4, TSH and cortisol levels during the puerperium. Subjects with higher levels of postpartum dysphoria had lower T4 and free T4 levels as well as higher T3 uptake at 38 weeks of pregnancy and higher cortisol levels during the puerperium. The pathophysiological implications of these findings are discussed.

Adult↗
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Psychological aspects of premenstrual syndrome. I: Cognition and memory.

Fourteen women with PMS and ten without PMS were evaluated with a battery of neuropsychological tests during the follicular and late luteal phases of two consecutive menstrual cycles. Classification was determined with NIMH diagnostic criteria and prospective record keeping. The results indicated that (1) the PMS women had significant difficulty in learning new material and this problem was not phase-dependent, (2) both groups performed better on a test of frontal lobe function during the follicular phase, and (3) mood did not account for any of the differences in cognitive functioning.

Adult↗
PubMedDate not supplied

Blood pressure-related hypoalgesia in bulimia nervosa.

OBJECTIVE: This study examined pain sensitivity and its relationship to arterial blood pressure in bulimia nervosa (BN). METHODS: Fourteen women who met Diagnostic and Statistical Manual of Mental Disorders, 4th Edition, criteria for BN, purging subtype, and 14 controls were tested for ischemic pain sensitivity after an extended baseline period. Blood pressure, cardiac output, stroke volume, and total peripheral resistance were assessed during baseline, during ischemic pain testing, and at the point of voluntary tolerance. RESULTS: Women with BN had significantly greater ischemic pain tolerance than controls. Additionally, only for BN women was blood pressure related to pain sensitivity. Systolic blood pressure during the pain procedure and at the point of tolerance was positively related to pain threshold and tolerance times and negatively related to rated unpleasantness of pain in BN, whereas no relationships involving blood pressure and pain sensitivity were observed in controls. CONCLUSIONS: These results may have implications for maladaptive changes in central pain-cardiovascular regulatory systems for women with BN.

Adult↗