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C A Primavesi

Publications and source records attributed to C A Primavesi.

10 recordsLinked to original sources
PubMed1990

Inhibitory and bactericidal activity of cefpirome and cefotaxime against blood culture isolates.

Using a broth microtiter dilution method, minimum inhibitory (MIC) and minimum bactericidal concentrations (MBC) were determined for the aminothiazolyl cephalosporins cefpirome and cefotaxime against 436 blood culture isolates. At concentrations of less than or equal to 16 mg/l, cefpirome inhibited 82.3% of the isolates and cefotaxime 66.5%. At the same concentrations, cefpirome killed 60.0% of the isolates and cefotaxime 46.7%. Whereas the MIC values indicated a far better activity of cefpirome than cefotaxime against oxacillin-resistant Staphylococcus aureus, Enterococci and Pseudomonas aeruginosa, the MBC values showed a poor activity of both drugs against these strains. By comparison, cefpirome was the more active agent, covering a similar spectrum to that of cefotaxime with a slight additional activity against oxacillin-susceptible S. aureus and Staphylococcus epidermidis.

Bacterial Infections↗
PubMed1987

[Results of virologic studies in 620 children with abacterial meningitis over a 15-year period (1971-1985)].

Cases of non-bacterial meningitis being hospitalized at the Children's Hospital of the University of Bochum in the years 1971 to 1985 were analysed retrospectively according to etiological and epidemiological aspects. Altogether 620 non-bacterial cases of meningitis were included in this study. For 378 (60.9%) children the infecting agent could be identified while in 242 cases (39.1%) the etiology remained open. In 237 cases enterovirus had been the causative agent. The average age of the patients was 6.5 years, boys were more frequently involved than girls (65% versus 35%). The majority of enterovirus infections occurred during the summer months July to September whereas (mumps) parotitis infections were equally distributed over the whole year. Yearly increases in certain enterovirus types were correlated to an increase in ECHO 11-infections in 1982, Coxsackie B5-infection in 1983 and 84 and ECHO 7-infection in 1985 based on data from the whole Federal Republic of Germany. However the majority of enterovirus-caused meningitis occurred during local endemics.

Adolescent↗
PubMed1979

[Cefazedone in infectious diseases in gynecology. Clinical tests on efficacy and tolerance].

A clinical trial on efficacy and tolerance of Cefazedone, a new semisynthetic Cephalosporine-derivate, was carried out in a gynaecological clinic on 75 patients. In 38 of these cases, besides the gynaecological affection, urinary tract infections were determined microbiologically (E. coli, P. mirabilis, klebsiella or enterococci). Inflammation of the lower abdominal area was established in the remaining 37 patients (adnexitis, pelvic peritonitis, endometritis, salpingitis). The average duration of treatment was 10 to 11 days. Cefazedone was injected intravenously twice a day, the daily dose was 2 to 4 g. The clinical assessment of the treatment was very good in 28 cases, good in 43 cases, moderate in 3 patients and poor in 1 case. All initially identified pathogens were eliminated after treatment. A slight transitory diarrhea was observed in 5 cases. There were no further side-effects. The values of gamma-GT, serum-creatinin, hemoglobin and erythrozytes were controlled before and after medication and showed no detremental effect of the drug. The local tolerance of Cefazedone was good in more than 90% of the cases treated.

Adult↗
PubMed1979

In vitro studies with cefazedone.

The minimum inhibitory concentrations of the new cephalosporin derivative (6R,7R)-7-(2-[3,5-dichloro-4-oxo-1(4H)-pyridyl]-acetamido)-3-([(5-methyl-1,3,4-thiadiazol-2-yl)-thio]methyl)-8-oxo-5-thia-1-azabicyclo[4,2,3]oct-2-ene-2-carboxylic acid (cefazedone, Refosporen) were tested in vitro against 358 bacterial strains. The antibacterial activity of cefazedone corresponds largely to that of cephalothin. Cefazedone is also active at a concentration of 16 micrograms/ml against 100% of enterococci, which can be classified as moderately effective, compared to cephalothin, which is completely ineffective. The MIC values from the dilution broth technique are in good correlation with the results determined by agar diffusion tests.

Bacteria↗