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C A Reese

Publications and source records attributed to C A Reese.

13 recordsLinked to original sources

Psychological measures: reliability in the assessment of stroke patients.

OBJECTIVE: To determine whether acute stroke patients can give reliable responses to standardized psychological measures. DESIGN: Survey design with retrospective review of Neurobehavioral Cognitive Status Examination (NCSE) scores. SETTING: A rehabilitation hospital in Philadelphia. PATIENTS: 106 consecutive admissions to stroke services at a rehabilitation hospital were evaluated according to the following inclusion criteria: Patients at least 65 years of age, English speaking, having a documented history of cerebrovascular accident (CVA), possession of receptive speech comprehension, and the ability to maintain attention adequate for participation in the study interview. Of the 47 eligible for participation, 10 patients refused participation and 13 were discharged before the interview could be completed. Thus 24 patients were interviewed, with one patient unable to complete the second half of the interview. MAIN OUTCOME MEASURES: In phase 1, the patient's performance on a structured interview (including the Multidimensional Health Locus of Control Scales (MHLC), Life Orientation Test (LOT), and Center for Epidemiological Studies Depression Scale (CES-D) scales) produced a Total Reliability Score, indicating the overall reliability of the patient's responses. In phase 2, NCSE scores were examined (retrospectively) for their ability to predict the patient's Total Reliability Score on the structured interview. RESULTS: Using Total Reliability Scores, 9 patients were categorized as "passing," 9 were categorized as "uncertain," and 5 were categorized as "failing" the interview. The NCSE was predictive for individuals who had a very low likelihood of being able to respond consistently. The NCSE failed to identify which individuals would respond in a reliable fashion. CONCLUSIONS: It is both possible and important to assess response reliability when using psychological measures soon after stroke. Future research will need to document other potential predictors of interview performance, including combinations of NCSE subscales.

Aged↗

Characterization of a highly soluble collagenous molecule isolated from chicken hyaline cartilage.

Recently, we have isolated a new collagenous molecule from chicken hyaline cartilage after limited pepsin digestion. This molecule, which contains interchain disulfide bonds, has been called the high molecular weight fraction or HMW [Reese, C. A., & Mayne, R. (1981) Biochemistry 20, 5443-5448]. We now present a detailed model for the structure of HMW, the model being derived from analyses both of components of HMW obtained after denaturation either with or without reduction and from electron microscopic observation of replicas of HMW obtained after rotary shadowing. We propose that HMW is a typical, triple-helical collagen molecule of length 134 nm, in which one of the chains has been cleaved at a distance of 96 nm from one end of the triple helix, while the other two chains remain uncleaved. The result of this cleavage is the appearance of a recognizable kink in molecules of HMW when visualized after rotary shadowing.

Amino Acids↗

Medication compliance in hyperactive children.

Medication compliance was studied over an 18-week period in 12 male children, ages 6 to 12 years, who were receiving medication for "hyperactivity." Subjects were randomly assigned to receive placebo (PB), d-amphetamine (AMP), and methylphenidate (MPH) for 6 weeks each in a triple-blind, crossover design. Urine samples were obtained weekly and assayed for MPH and AMP to assess compliance. Individual patient compliance varied from 0.00% to 100% (x = 67%) while taking MPH and from 20% to 83% (x = 60%) while taking AMP. The percent of patients compliant for a given week varied from 55% to 80% (x = 67%) when taking MPH and from 25% to 83% (x = 61%) when taking AMP. Significant positive noncompliance also occurred; ie, MPH was found in urine during the PB period in five of 12 individuals. Poor compliance in taking medication may explain, in part, the variable and conflicting results reported in many studies of the effect of medication on improving the behavior of hyperactive children.

Attention Deficit Disorder with Hyperactivity↗