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Biomedical subjects

C A Salles

Publications and source records attributed to C A Salles.

At least 37 records · Page 2Linked to original sources
PubMed1980

Phospholipids associated with vitamin C in experimental atherosclerosis.

The favourable action of phospholipids and of Vitamin C in reverting the process of atherogenesis, already repeatedly described in the literature, was explored by the authors in applying an association of these two substances in experimental atherosclerosis. The obtained results not only confirm, once again, the prophylactic and therapeutic activity of phospholipids and vitamin C, but also demonstrate that these components, when associated, lead to much better results in the prevention and resolution of atheromatous plaques provoked in rabbits by cholesterol-feeding.

Animals↗
PubMed1977

Extraanatomical bypass of the aortic root: an experimental technique.

Endocarditis involving a prosthetic aortic valve is associated with persistently positive blood cultures and aortic regurgitation. With rare exception, it is a fatal disease. An experimental technique was developed that would allow for removal of the infected aortic prosthesis with debridement and permanent closure of the aortic root. An extraanatomical outflow for the left ventricle was created using a valve-containing conduit between the apex of the left ventricle and the descending thoracic aorta (apicoaortic anastomosis). The procedure was performed on 5 mongrel dogs through a left thoracotomy without use of cardiopulmonary bypass. Four survived the procedure and required no cardiotonic support. One died as a result of a technical problem. Intraoperative pressure determination revealed a 0 to 15 mm Hg gradient across the apioaortic prosthesis and a left ventricular end-diastolic pressure of 0 to 4 mm Hg. Both postoperative angiocardiogram and postmortem examination confirmed patency of the aortocoronary bypass grafts and good function of the prosthesis.

Adolescent↗
PubMed1976

Long-term patency of vein grafts preserved in liquid nitrogen in dimethyl sulfoxide.

Autogenous canine jugular veins were stored in 15% dimethyl sulfoxide (DMSO) in liquid nitrogen vapor for one to 28 days and then implanted in the carotid artery as autografts. The patency rate at one year was 62.5-87.5%. The patency rate of fresh jugular vein autografts placed in the carotid artery for one year was 75%. Similar autografts stored in liquid nitrogen vapor for one to 28 days without the cryopreservative DMSO exhibited a zero to 12.5% patency rate at one year. Scanning electron microscope studies revealed preservation of theendothelium in DMSO protected veins and a damaged or sloughed endothelium in veins frozen without DMSO cryopreservation.

Animals↗
PubMed1976

Focal infection of aortofemoral prostheses.

A canine model of unilateral aortofemoral bypass was utilized to study periprosthetic infections in woven, knitted, and velour Dacron vascular prostheses. These studies suggest that physical configuration, porosity, and time of inoculation all are important variables when managing an infected prosthesis, although size of inoculum seems less important.

Abscess↗
PubMed1976

The use of velour as a vascular prosthesis.

Knitted Dacron cloth fabricated into tubes has gained widespread acceptance as an arterial prosthesis. Continued research and development in the field of vascular prostheses is required because existing materials are not ideal. This paper relates general developments in vascular prosthesis research and focuses on specific results with Dacron velour materials. The nature of the velour surface offers several advantages that are important in designing a more satisfactory prosthesis.

Animals↗
PubMed1976

A different approach for the total correction of tricuspid atresia.

A new surgical procedure has been used successfully to correct tricuspid atresia in a 9-year-old girl. An external conduit containing a porcine aortic valve was positioned to lead from the right atrium to the underdeveloped right ventricle. The right ventricle was reconstructed with a large Dacron patch, thus providing a large cavity for the small hypoplastic right ventricle. The atrial and ventricular septal defects were closed. The patient made a satisfactory recovery and is doing well four months after the operation.

Cardiac Catheterization↗
PubMed1975

An infallible method for producing ascitic fluid from solid tumours.

Notwithstanding all precautions, the methods usually applied for the transformation of solid tumours into the ascitic form, frequently fail. This must certainly be ascribed to the still existing, considerably high intercellular adhesion forces despite the fact that cancer cells generally show lack of adhesiveness due to their higher electrical charge in comparison with normal cells. Hagmar recently stipulated that particularly anionic detergents increase the negative surface charge of tumour cells, while cationic detergents drastically reduce or even reverse this charge. A series of comparative experiments were undertaken by us in order to study the influence of anionic, nonionic and amphoteric detergents on the production of ascitic fluid from macerates of Yoshida sarcoma and fibrosarcoma BUSP. This latter tumour was produced and maintained in our laboratory and resisted to all our attempts to produce the ascitic form. Heparin, in concentrations of 0,2, 0,4 and 1,0 mg/ml, was used as an example of an anionic detergent; Pluronic F-68 and phosphatidylcholine, both in concentrations of 1, 2, and 5 mg/ml, represent a nonionic and an amphoteric detergent, respectively. The obtained results clearly show a most favourable action of the applied surfactants: whereas the controls, in which the detergents were not applied, failed to produce ascitic fluid in, sometimes, considerable percentages (up to 100% in the case of BUSP) of the treated animals, not a single animal remained free of ascite when the injected macerate was pre-treated with the emulsifier. It should here be mentioned, however, that heparin in the highest concentration applied (1 mg/ml) caused lysis of the tumour cells impeding, thus, whatever formations of ascitic fluid.

Animals↗