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Biomedical subjects

C A Sczupak

Publications and source records attributed to C A Sczupak.

7 recordsLinked to original sources
PubMed1979

Outpatient oral anticoagulation: guidelines for long-term management.

The experience with outpatient anticoagulation services (ACSs) in two municipal teaching hospitals has been reviewed. These two ACSs have provided therapy with a major hemorrhagic morbidity of 4.1% based on patient treatment years and with no anticoagulation-related mortality. Their major goal has been to provide safe, efficient monitoring of anticoagulation control for the patients of a wide variety of primary care physicians in the hospital clinics. With careful patient selection and education, monitoring of the duration of therapy, and close communication among patient, primary care physician, and pharmacist, this goal has been achieved.

Administration, Oral↗
PubMed1978

Liquid-chromatographic determination of serotonin in serum and plasma.

Using high-performance liquid chromatography with electrochemical detection, we determined serotonin in plasma from parkinsonian patients being treated with L-3,4-dihydroxyphenylalanine or N-(DL-seryl)-N'(2,3,4-trihydroxybenzyl)hydrochloride plus L-3,4-dihydroxyphenylalanine ("Sinemet") and in serum from a blood bank, from "normal" persons, and a pooled specimen from a hospital clinical laboratory. The values obtained for the two groups of Parkinson's disease patients showed no significant difference. Long-term storage on solid CO2 was xhown to be an adequate technique for preserving samples. The mean (+/-SEAM) normal value obtained for serotonin in serum was 146 +/- 46 microgram/liter (n = 23), a result in harmony with that previously obtained [Clin. Chem. 20, 812 (1974)] by fluorometry. In comparison to other methods for measurement of serotonin in serum or plasma, we believe that the present scheme offers greater selectivity, sensitivity, and precision.

Biogenic Amines↗