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Biomedical subjects

C A Sullivan

Publications and source records attributed to C A Sullivan.

59 records · Page 4Linked to original sources

Parous patients' estimate of birth weight in postterm pregnancy.

Our objective was to determine among postterm gestations (gestational age > or = 41 weeks) the accuracy of a parous patient's (n = 70) estimate of her newborn's birth weight and to compare the accuracy of clinical prediction with the assessment by the parturient (n = 40). During early labor 70 postterm parous subjects were asked to predict the birth weight of their neonate on the basis of their prior obstetric experiences. For comparison, a concurrent clinical estimate of the birth weight by the provider was also obtained in 40 of these patients. The incidence of macrosomia (birth weight > or = 4000 gm) among postterm parous mothers was 25.7%. The mean standardized error of the maternal estimate of birth weight was 85 +/- 76 gm/kg and 71.4% of their estimates were within +/- 10% of actual birth weight. Maternal estimate of birth weight > or = 4000 gm had a 94% specificity and 77% positive predictive value for a macrosomic fetus. Among 40 postterm parous women the clinical estimate had a mean standardized error (75 +/- 71 gm/kg) comparable to that of the maternal prediction (92 +/- 81 gm/kg) of birth weight (p = not significant). The mean standardized error among estimates for 11 macrosomic newborn infants who underwent both methods of estimation of birth weight was not significantly different. In conclusion, postterm parous women are at risk for delivery of a macrosomic fetus. Among these parturients, an estimate of birth weight by parous women is comparable to the clinical prediction of newborn weight by their providers.

Adult↗

Diabetic ketoacidosis complicating pregnancy.

OBJECTIVE: This report describes the physiologic alterations that predispose pregnant women to diabetic ketoacidosis and the experience in a tertiary center after adoption of aggressive management of diabetics. STUDY DESIGN: In 1982 a protocol for strict surveillance of glucose homeostasis for pregnant diabetic patients and the early recognition and aggressive treatment of patients who do have diabetic ketoacidosis was initiated and has resulted in improved maternal and neonatal outcomes. RESULTS: From 1986 through 1991 the incidence of diabetic ketoacidosis was 3% compared with an incidence of 22% from 1976 to 1981. During this same time the incidence of fetal death associated with diabetic ketoacidosis decreased from 35% to 10%. CONCLUSION: Diabetic ketoacidosis and fetal morbidity/mortality can be reduced by aggressive management during pregnancy.

Adult↗

Sleep patterns in pregnancy: a longitudinal study of polysomnography recordings during pregnancy.

OBJECTIVE: To evaluate the differences in sleep of women throughout pregnancy compared with those of nonpregnant control subjects. STUDY DESIGN: Four pregnant women were studied longitudinally during their pregnancy using inpatient polysomnography. Measurements included electroencephalography, electrocardiography, and continuous-pulse oximetry. Four healthy nonpregnant women matched for age and weight were used as control subjects. The total sleep time was recorded, and percentages of each sleep stage were generated. RESULTS: Qualitative differences in sleep between pregnancy patients and control subjects were evident. Control subjects displayed a normal appearance of slow-wave sleep in stages 3 and 4 (delta sleep). When pregnant patients did display delta sleep, it appeared abnormal secondary to extensive alpha-wave intrusion. Even when including this abnormal delta sleep in a quantitative comparison, the pregnant patients had a significantly shorter percentage of total sleep time in delta sleep (4.9+/-1.9% vs 21.9+/-6.0%, p=0.03). CONCLUSION: Sleep in pregnancy is characterized by loss of normal slow-wave sleep. Thus, sleep stages 3 and 4 are shortened during pregnancy. This sleep alteration is persistent when followed longitudinally during pregnancy.

Adult↗