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Biomedical subjects

C Abramson

Publications and source records attributed to C Abramson.

At least 19 recordsLinked to original sources
PubMed1993

Infection and the older patient.

An increasing number of elderly patients are in and out of doctors' offices, hospitals, nursing homes, and so forth, under continual medical care. Numerous invasive procedures allow for casual transfer of infectious diseases by fellow patients as well as health care workers. Dramatic increases in infectious diseases such as foot infections, pneumonia, staphylococcal infections and, because of necessary invasive and blood transfusion procedures, AIDS can be expected in the future. The elderly patient is often a debilitated, compromised, immunodeficient host who is highly susceptible to any number of infections. With this in mind as the population grows older, clinicians must begin to apply Universal Precautions in their practices if they have not already done so, and not underestimate any disease or symptom in any patient, regardless of their age or their condition.

Aged↗
PubMed1992

Inhalation of nail dust from onychomycotic toenails. Part I. Characterization of particles. 1984.

Nail dust particles were analyzed by scanning electron microscopy for size and topography. The percentage of "fines" that could be inhaled and deposited in the alveoli and bronchioles were determined by quantitative particle size analysis. Distribution representing the largest total mass was graphed between 1 and 2 microns. The authors found that 86% of nail dust would reach the bronchioles and alveoli, and 31% could be expected to deposit in these areas.

Dust↗
PubMed1992

Nail dust aerosols from onychomycotic toenails. Part II. Clinical and serologic aspects. 1984.

The podiatric procedure of burring hyperkeratotic fungal infected toenails results in large quantities of nail dust aerosols. An extremely large percentage (31%) of podiatrists who were analyzed for immunoglobulin E (IgE) by antibody radioimmunoassay were found to have abnormally high levels. Incidence of precipitin antibodies to Trichophyton rubrum in sera of those in practice from 0 to 15 years was 23%, and those in practice 16 years or more was 29%. In this study, podiatrists who were chronically exposed to nail dust aerosols after years of practice presented with symptoms of conjunctivitis, rhinitis, asthma, coughing, hypersensitivity, and impaired lung function.

Aerosols↗
PubMed1991

Diagnosis and treatment of tinea pedis. A review and update.

Fungal foot infections are becoming an increasingly common public health problem as the population ages. New studies have shown that some of the traditional therapeutic antifungal agents have multiple actions that enable them to be more efficacious than previously thought, and more efficacious than other agents without multiple actions. In this review article, the pedal infections commonly referred to as tinea pedis, or athlete's foot, are described. The etiologic agents involved in the pathogenesis, the methodologies for proper diagnosis, and the therapeutic agents commercially available for treatment are reviewed.

Antifungal Agents↗
PubMed1990

Athlete's foot and onychomycosis caused by Hendersonula toruloidea.

Fungi other than the dermatophytes can cause infections of the foot, toes and toenails that simulate classic "athlete's foot." Unless diagnosed culturally and morphologically by the clinical laboratory, treatment failures may occur. The saprophyte Hendersonula toruloidea as well as other fungi and yeasts reported to cause such infections have been shown to be clinically indistinguishable from classic dermatophytic "athlete's foot." The clinical and laboratory diagnosis of these types of foot infections caused by Hendersonula toruloidea are described. Specific transport media required for laboratory diagnosis and therapeutic alternatives are reviewed.

Antifungal Agents↗
PubMed1982

Clinical usefulness of monoclonal-antibody phenotyping in childhood acute lymphoblastic leukemia.

Lymphoblasts from 59 children with non-T, non-B acute lymphoblastic leukaemia were studied with monoclonal antibodies to four cell-surface proteins. 87% of the children had lymphoblasts positive for HLA-DR, 82% for p30, 75% for p24, and 72% for CALLA. The commonest composite phenotype was HLA-DR+ p30+ CALLA+ p24+. Significant correlations were seen between expression of HLA-DR, p30, and CALLA, but not p24. p30- and CALLA phenotypes were found in patients with high white-blood-cell counts (WBC) and splenomegaly. With standard chemotherapy, disease-free survival from time of remission was shorter in p30- and CALLA- patients than in others. Splenomegaly was associated with poor disease-free survival and provided prognostic information independent of phenotype. High WBC was less significant than phenotype in predicting outcome and was not independent of phenotype.

Adolescent↗