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C Adair

Publications and source records attributed to C Adair.

23 records · Page 2Linked to original sources
PubMed1984

Dialysate flow rate and peritoneal clearance.

We evaluated the influence of dialysate flow rates upon peritoneal clearance of urea, creatine, protein losses into dialysate, glucose disappearance from dialysate, sodium removal from the patient during dialysis, and ultrafiltration rate in 64 patients undergoing intermittent peritoneal dialysis. We evaluated three dialysate flow rates: 2 L/h, 3 L/h, and 4 L/h. All dialysate contained 1.5% glucose. The clearance of urea in milliliters per minute (2-L series 14.0, 3-L series 15.1, 4-L series 17.6) and creatinine in milliliters per minute (2-L series 9.3, 3-L series 10.6, 4-L series 11.6) determined at a dialysate flow rate of 4 L/h was significantly greater than the clearances determined at 3 and 2 L/h of dialysate flow (P less than 0.05). The clearance of glucose from the peritoneal cavity in milliliters per minute (2-L series 6.9, 3-L series 7.9, 4-L series 8.9) was significantly greater for the 4-L series as compared with the 2-L series (P less than 0.05). There were no other significant differences. Neither sex, race, previous episodes of peritonitis, nor etiology of renal failure influenced the results. Given the high cost of dialysate, we recommend dialysate flows of 2 L/h if a patient has a residual renal clearance of 2.5 mL/min. Although increasing dialysate flow rate may compensate for renal clearances significantly less than this, we believe the patient should be offered hemodialysis, continuous cyclic peritoneal dialysis (CCPD), or continuous ambulatory peritoneal dialysis (CAPD).

Creatinine↗
PubMed1982

Augmentation of peritoneal clearance by dipyridamole.

We performed a double blind crossover trial in which dipyridamole was administered to ten patients undergoing intermittent peritoneal dialysis at 2 liters/hour (10 min infusion, 30 min intraperitoneal dwell of dialysate and 20 min drainage of dialysate). After the patients received the drug for 3 days at a dose of 75 mg three times daily, peritoneal inulin clearance increased by 1.2 ml/min (P less than 0.05), and glucose absorption increased by 12.1 g (P less than 0.05). The mechanism of the observed drug-induced effects is unknown.

Adult↗
PubMed1982

Stereospecific lactate absorption during peritoneal dialysis.

Patients undergoing peritoneal dialysis were studied to determine if peritoneal absorption was selective. Dialysis was performed using dialysate exchange schedules similar to those for intermittent peritoneal dialysis and continuous ambulatory peritoneal dialysis. The clearance rate from the peritoneal cavity during hourly dialysate exchanges was 6.2 ml/min for D (-)-lactate and 8.7 ml/min for L(+)-lactate (p less than 0.01). L(+)-Lactate disappeared more rapidly from the dialysate during the long-cycle exchanges. Our results suggest that clearance of lactate from the peritoneal cavity is relatively stereospecific and raises the question of selective absorption for other organic anions.

Adult↗
PubMedDate not supplied

Rare primary CNS anaplastic large cell lymphoma in an immunocompetent adult: a clinical-pathologic case report and review case of the literature.

OBJECTIVE AND IMPORTANCE: Isolated anaplastic large cell lymphoma (ALCL) presenting in the primary central nervous system is distinctly uncommon. The authors describe a case that clinically and radiographically simulated a primary glial neoplasm. CLINICAL PRESENTATION: A 39-year-old immunocompetent male presented with seizures and a rapidly enlarging right occipital/parietal lesion. Magnetic resonance images demonstrated a right occipitoparietal lesion, hypodense on T1WI, with patchy contrast enhancement with gadolinium and significant white matter edema pattern on T2WI along with mass effect and midline shift. INTERVENTION: The patient underwent a frameless stereotactic assisted needle biopsy. There appeared to be a clear demarcation between white matter and tumor with no obvious necrosis. Biopsy showed a proliferation of single cells and poorly cohesive groups of cells with large, pleomorphic nuclei, many containing prominent nucleoli, and a moderate amount of cytoplasm. Immunohistochemical staining revealed CD-30 and ALK-positivity typical of ALCL, a rare form of T-cell lymphoma. An extensive workup revealed neither systemic disease nor evidence of immunocompromise. CONCLUSION: Reported in less than 20 patients, primary ALCL in an immunocompetent patient is rarely found intracranially; however, its ability to mimic glial neoplasms as well as other pathologies underlines its importance.

Adult↗