The effect of urea and mannitol on cochlear blood flow.
Explore the source record for details and available documents.
Animals↗
Biomedical subjects
C Angelborg
Publications and source records attributed to C Angelborg.
The microsphere surface technique for evaluation of cochlear vessels and circulation. A preliminary report.
A new technique for the evaluation of cochlear microcirculation and cochlear vessels is described. This method is a modification of two previously used techniques, the "soft-surface-specimen method" and the "microsphere method". In this preliminary paper it was found that the microspheres were easily visualised in all cochlear tissues. The absolute and relative distribution of microspheres was calculated. The method appears promising for experimental investigations of cochlear microcirculation.
Animals↗
Cochlear blood flow studied with microspheres. A comparison between two different modifications of the microsphere method.
In albino rabbits, spontaneously hypertensive rats, and guinea pigs, cochlear blood flow was measured with the microsphere method, using radioactively labelled microspheres technique and a gammaspectrometer. This 'conventional' microsphere method was compared with a new technique for measurements of cochlear blood flow: a modification of the 'radioactive' microsphere technique and the soft surface specimen technique. Values obtained for cochlear blood flow by the two different methods were similar. Consequently, the microsphere surface technique is a suitable alternative to the classical radioactive microsphere method for blood flow determinations in the cochlea.
Acid-Base Equilibrium↗
The vestibular blood flow during CO2-breathing in rabbits.
The microsphere method was used to measure the inner ear blood flow in albino rabbits before and during artificial ventilation with 5% CO2 in air. An increase in blood flow resulted in both the cochlear and the vestibular parts of the inner ear.
Animals↗
Cochlear blood flow in endolymphatic hydrops.
There is no animal model for Meniere's disease but by obliteration of the endolymphatic duct, endolymphatic hydrops may be achieved in several animal species. In order to measure the cochlear blood flow in ears with endolymphatic hydrops the endolymphatic duct was obliterated in 9 guinea pigs. The blood flow was measured with the microsphere method and the cochlear histology was studied. The regional and total blood flow was determined in the serially sectioned cochleas 2, 4 and 8 months after obliteration of the endolymphatic duct. No change in regional or total cochlear blood flow was observed in the hydropic ears.
Animals↗
Regional blood flow patterns along the length of the rodent cochlea.
The cochlear blood flow within the different vascular beds of the cochlea was examined in rats and guinea pigs. Using a computer-assisted reconstruction technique, the position of the microspheres within the cochlea was determined and their percentage distribution along the length of the sensory epithelium was calculated. In the present experiments, differences in blood flow were observed along the length of the cochlea. Within one species the pattern in each of three vascular areas varied independently of the other. When the two species are compared, the pattern for blood flow to the individual vascular beds along the length of the sensory epithelium is similar. The differences observed may reflect differences in cochlear anatomy, or correlate with biochemical and metabolic longitudinal gradients known to exist in the cochlea.
Animals↗