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Biomedical subjects

C Appel

Publications and source records attributed to C Appel.

10 recordsLinked to original sources
PubMed2001

Outpatient biochemotherapy with interleukin-2 and interferon alfa-2b in patients with metastatic malignant melanoma: results of two phase II cytokine working group trials.

PURPOSE: The Cytokine Working Group performed a randomized phase II trial of two outpatient biochemotherapy regimens to identify an outpatient regimen with high antitumor activity and less toxicity than inpatient regimens which might be compared with chemotherapy or inpatient biochemotherapy regimens in future phase III trials. PATIENTS AND METHODS: Eighty-one patients with metastatic malignant melanoma received dacarbazine 250 mg/m(2)/d intravenously (IV) and cisplatin 25 mg/m(2)/d IV on days 1, 2, and 3, plus interferon (IFN) alfa-2b 5 mU/m(2) subcutaneously (SC) on days 6, 8, 10, 13, and 15, given every 28 days. Interleukin-2 (IL-2) was given daily on days 6 to 10 and 13 to 15. In group 1, IV IL-2 was given at 18.0 MU/m(2), and in group 2, SC IL-2 was given at 5.0 mU/m(2). RESULTS: In group 1 (IV IL-2), there were five complete responses (CRs) and 11 partial responses (PRs) among 44 patients (objective response rate [ORR], 36%; 95% confidence interval [CI], 22% to 51%). In group 2 (SC IL-2), there was one CR and five PRs among the 36 patients (ORR, 17%; 95% CI, 4% to 29%). The median survival was 10.7 months in group 1 and 7.3 months in group 2. Eleven patients in group 1 and four patients in group 2 remain alive as of the last follow-up. Toxicities in both groups were similar. No patient required hospitalization for neutropenic fever. CONCLUSION: Biochemotherapy has activity in these outpatient regimens with acceptable toxicity. The antitumor activity observed with the IV IL-2 regimen seems similar to that of inpatient biochemotherapy regimens. If inpatient biochemotherapy regimens develop an established role in the management of melanoma, future phase III trial comparisons with this outpatient IV IL-2 regimen would be appropriate.

Adult↗
PubMed1996

Expression of a Na,K-ATPase beta 3 subunit during development of the zebrafish central nervous system.

Zebrafish beta 3, a full length cDNA clone encoding a zebrafish Na,K-ATPase beta subunit, was isolated. The protein shares highest homology with the beta 3 subunits of amphibians and mammals, slightly less homology with the beta 2 subunits, and is distinct from the beta 1 subunits. The fish beta subunit co-assembled with alpha subunits to form Na,K-ATPase enzymes when expressed in Xenopus oocytes. Embryonic expression was first detected by whole-mount in situ hybridization between 8-12 hr post-fertilization (hpf) in the head mesoderm. Subsequently, and up to 24 hpf, the mRNA was confined to four dorsal domains in the anterior neural tube. After a transient downregulation during the second day, expression was again conspicuous in the nervous system of 3-day-old larvae. Based on its distribution pattern, the fish beta subunit could be involved in setting up regional identities in the developing fish CNS and in the differentiation of distinct cell types.

Amino Acid Sequence↗
PubMed1994

Phase II evaluation of oral estramustine and oral etoposide in hormone-refractory adenocarcinoma of the prostate.

PURPOSE: Estramustine and etoposide (VP-16) have been demonstrated to inhibit the growth of prostate cancer cells in experimental models. This led us to evaluate the effectiveness of this combination in the treatment of patients with metastatic prostate carcinoma refractory to hormone therapy. PATIENTS AND METHODS: Estramustine 15 mg/kg/d and VP-16 50 mg/m2/d, were administered orally in divided doses for 21 days. Patients were then taken off therapy for 7 days and the cycle then repeated. Therapy continued until evidence of disease progression. RESULTS: Forty-two patients have been enrolled onto this trial with a minimum of 40 weeks follow-up. Of 18 patients with measurable soft tissue disease, three demonstrated a complete response (CR) and six a partial response (PR) for longer than 2 months. Of these 18 patients, pretreatment prostate-specific antigen (PSA) levels decreased by at least 75% in five men (28%) and by at least 50% in nine (50%). The median survival duration has not been reached in those patients who demonstrated a response either by soft tissue or PSA criteria. Of 24 patients with disease limited to bone, six (25%) demonstrated improvement and nine (38%) demonstrated stability in their bone scans. Five men (21%) demonstrated a decrease of at least 75% in pretreatment PSA levels and 14 (58%) demonstrated at least a 50% decrease; the median survival duration has not been reached in these patients. Pretreatment performance status is an important predictor of survival. CONCLUSION: We conclude that the combination of estramustine and VP-16 is an active oral regimen in hormone-refractory prostate cancer.

Adenocarcinoma↗
PubMed1987

[Diagnostic value of magnetic resonance tomography in disseminated encephalomyelitis].

In 83 of 86 patients with multiple sclerosis (MS) cranial magnetic resonance imaging (MRT) demonstrated lesions consistent with the clinical diagnosis. All the patients had either clinically typical MS oralaboratory-confirmed diagnosis of MS. The sensitivity of MRI is compared to those of computed tomographic (CT) scanning, evoked potential testing and cerebrospinal fluid analysis. The features of MS revealed by MRI are interpreted in terms of the macroscopic pathology and correlated with the clinical findings. The importance of particular findings (cystic appearance of lesions, spread of periventricular patches into the centrum semiovale) for the patients prognosis in stressed.

Adolescent↗
PubMed1977

Virus transfer from surf to wind.

Bubbles in the sea surf adsorb and carry viruses to the surface where they are propelled into the air on tiny jets of seawater when the bubble bursts. The ejected jets become tiny drops of aerosol. The buble adsorption and virus concentration in the surf is analagous to industrial bubble levitation processes that concentrate metallic ores, enzymes, and finely divided organic crystals. Bubble levitation of viruses delibrately injected into the surf produced 200 times more virus per milliliter in the aerosol than were present in samples from the surf. Some aerosol drops created by the surf and carried by the wind fall out on the beach. The frequency of virus-bearing drops, that is, the number of plaques on seeded plates exposed on the beach, decreased exponentially with the distance downwind from the surf.

Aerosols↗
PubMed1975

[The electro-oculogram in the early postoperative period following fistulizing operations (author's transl)].

EOGs were obtained from 2 groups of patients suffering from glaucoma chronicum simplex the day before surgery and 3, 5, 8, 11 and 14 days after trephining or fistulizing operation after Scheie. Though and peak potentials of the treated eyes were significantly less than those of the untreated fellow eyes five days after surgery. In addition on the 11. postoperative day after Scheie a second potential decrease was seen. The EOG-changes observed appear to reflect disturbances of the choroidal circulation after fistulizing operations.

Aged↗