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Biomedical subjects

C Arion

Publications and source records attributed to C Arion.

At least 19 recordsLinked to original sources
PubMed1991

[Infantile spasms (infantile myoclonic encephalopathy with hypsarrhythmia)].

The paper reports on a very important aspect in a pediatric practice, referring to one of the most severe forms of epilepsy of the infant, known in the modern specialty literature as infantile spasms. The paper reviews the etiologic data of the disease in its secondary form, with emphasis on the form of the disease better studied in the last years, i.e. the so-called infantile benign epileptic spasms. The paper also analyzes the clinical and electroencephalographic aspects, discuss the most important aspects of the differential diagnosis that includes some entities recently individualized and appreciates, on the basis of the most topical literature data, the nature of the different treatment means used, and of the evolution and prognosis.

Brain↗
PubMedDate not supplied

[Antiviral chemotherapy in pediatrics--its present and prospects].

Authors discuss the general aspects of viral infections and the principles of antiviral chemotherapy. First section deals with the stages, the types of viral infections and the basic principles for action of antiviral drugs. Authors review also the up-to-date situation of antiviral therapy in pediatrics, the problem of resistant strains and formulate the expected progress in the field of antiviral chemotherapy.

Antiviral Agents↗
PubMedDate not supplied

[The diagnostic algorithm in neonatal infections].

Authors review the principles of diagnosis in neonatal bacterial infections (local and systemic), in congenital, peri- and postnatal viral infections and also in Candida spp. and other mycotic infections of the neonatal period. They try to delineate the clinical and epidemiological criteria of suspicion and modalities of confirmation of the neonatal infections by specific paraclinical methods. Attention is focused on modern diagnostic methods (such as immunofluorescent techniques, counterimmunoelectrophoresis and so on), which are important for the early etiological diagnosis and for thr rapid initiation of specific therapy. Authors made a practical diagnostic algorithm for the most frequent encountered neonatal infections. They also focused on the recent changes in the etiology of neonatal infections and their therapeutic significance.

Algorithms↗
PubMedDate not supplied

[Pathogenetic mechanisms in neonatal infections].

The authors reviewed the pathogenetic mechanisms of ante-, intra- and postnatal infections of the newborn. They also discussed the results of the antenatal infections on embryo and foetus, and the clinical variants of intra- and postnatal infections. The attention is focused on the relationship between pathogenetic mechanisms and the relevant clinical and paraclinical alterations for the diagnosis of the most frequent encountered infections of the newborn.

Communicable Diseases↗
PubMedDate not supplied

[The characteristics of the anti-infectious defenses in newborn infants].

The authors reviewed the up to date conceptions concerning the temporary alterations of the host defense mechanisms in the neonatal period (natural barriers, macrophages, complement system, cell-mediated and humoral immunity). They try to establish correlations between this temporary alterations and the high infectious risk and the severity of most of the infections in the newborn. A special attention is paid to the peculiar situation of the premature, and also to the modifications needed in the therapeutic schedules for serious neonatal infections.

Antigen-Antibody Reactions↗
PubMedDate not supplied

[Neonatal convulsions: the current concepts and classification].

The authors presented a new classification of the neonatal convulsions, based on prolonged EEG registrations related to concomitant clinical or videorecording of fits. They focussed on the atypical neonatal convulsions and on the differential diagnosis between epileptic and nonepileptic seizures. Finally, they discussed the therapeutical consequences of these new conceptions about the conclusions in the neonate.

Electroencephalography↗
PubMedDate not supplied

[The diagnosis of conjugated bilirubin jaundice in children].

The paper reports on the development of the diagnosis algorithm in jaundices with conjugated bilirubinemia in children. The clinical hepatobiliary semeiology, the data of the objective clinical examination and the laboratory and paraclinical examinations of hepatic exploration are analyzed. The paper also presents the diagnosis phases in the main clinical biological syndromes met in the child with jaundice and conjugated bilirubinemia: acute hepatic syndrome, chronic hepatic syndrome and cholestatic syndrome.

Algorithms↗
PubMedDate not supplied

[Risk factors in infant morbidity and mortality].

The authors approach a notion of great present day interest--namely risk factors determining infantile morbidity and mortality. They review the methods for study and identification of risk factors and analyse the relative frequency and importance depending on the maternal-infantile biosystem and exogenous, environmental factors, showing the strategy of the control (reduction) of infantile mortality based upon the identification and knowledge of risk factors. The study is of practical value allowing pediatricians at all levels of the maternal-infantile network to perfect medical surveillance of the population at risk and to plan differentiated individual care for infants and children whose health status exposes them especially to risk.

Adult↗
PubMedDate not supplied

[Immunologic anomalies in inflammatory diseases of connective tissue in children].

A comparison was made between the results of an analysis of humoral immunological changes in 64 cases of inflammatory diseases of the connective tissue of children (32 cases of ACJ, 5 cases of systemic lupus erythematosus, 2 cases of polymyositis, and 25 cases of systemic vasculitis), and data reported in recent literature, the authors conclude as follows:--changes of the immunological parameters that were tested support the hypothesis of a humoral immunopathogenic mechanism in systemic lupus erythematosus, in some of the manifestations of ACJ, and in systemic vasculitis;--of particular value for the immunological diagnosis of ACJ is the detection of FR in the patients' serum (and especially of FR from the IgG and the IgA class), as well as changes of immunological parameters of the articular fluid (the presence of FR, of immune complexes, a reduction of the titer intra-articular complement, the presence of ragocytes);--demonstration of humoral immunological changes (polyclonal hypergammaglobulinemia, the presence in the serum of circulating immune complexes, and of cryoglobulins, the low titer of serum complement in active stages, the presence of antinuclear antibodies, and especially of antinative DNA, the presence of LE cells in peripheral blood, and of a varied range of autoantibodies) is mandatory for the diagnosis of systemic lupus erythematosus;--in the present stage of our knowledge humoral immunologic changes are not an absolutely certified criterion for the diagnosis of polymyositis, and of some cases of systemic vasculitis (Henoch-Schoenlein purpura).

Antibody Formation↗