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Biomedical subjects

C Ayrolles

Publications and source records attributed to C Ayrolles.

At least 19 recordsLinked to original sources
PubMed1989

High diagnostic value in rheumatoid arthritis of antibodies to the stratum corneum of rat oesophagus epithelium, so-called 'antikeratin antibodies'.

Serum antibodies to the stratum corneum of rat oesophagus epithelium, so-called 'antikeratin antibodies', have been largely demonstrated in rheumatoid arthritis (RA). IgM and IgG antibodies to this epithelium were studied by semiquantitative immunofluorescence in 528 patients with perfectly characterised rheumatic diseases, including 178 with classical or definite RA. Histological analysis of IgG antibodies showed that only antibodies which produce a linear laminated pattern restricted to the stratum corneum (IgG antikeratin antibodies) are highly specific for RA; all the other labelling patterns are not disease specific. By a semiquantitative evaluation of the stratum corneum fluorescence intensity it was shown that the diagnostic value of IgG antikeratin antibodies closely depends on their titre and it was established in objective conditions that the sensitivity is 43.26% when the specificity reaches 99.14%. A high titre of IgG antikeratin antibodies was actually pathognomonic for RA. Both the histological and semi-quantitative analyses showed that IgM antibodies to rat oesophagus epithelium, though frequently detected, are of no diagnostic value, either for RA or for any other rheumatic disease that was studied. From a review of all the international reports on IgG antikeratin antibodies it was found that, to date, 4080 patients, including 1694 with RA, have been assayed for antikeratin antibodies by 11 different research groups. Analysis of all the results obtained under comparable technical conditions showed that IgG antikeratin antibodies constitute the most specific serological criterion for the diagnosis of RA. Furthermore, it was found that their incidence does not depend on disease duration: they are present in one third of rheumatoid factor negative patients with RA, and they seem to be related to disease severity or activity, or both. Their detection in the diagnosis of rheumatic diseases should become systematic.

Adolescent↗
PubMed1983

[Double-blind comparative study of Bi-Profenid tablets and Profenid capsules in inflammatory rheumatism].

The effectiveness of Bi-Profenid tablets and Profenid capsules was studied comparatively in patients with inflammatory joint disease. 43 patients with rheumatoid arthritis or various chronic inflammatory joint diseases were given 300 mg of Bi-Profenid in 2 daily oral doses and 300 mg of Profenid in 3 daily oral doses, for two consecutive 7 day periods. This double blind cross-over study was carried out in two rheumatology centers. Effectiveness of the two forms of ketoprofen on morning stiffness and pain scale was found to be comparable. However, patients more often preferred Bi-Profenid (15 cases) to Profenid (10 cases); 12 patients reported no difference. Tolerance was excellent in 92.7% of cases under Profenid capsules and in 94.8% of cases under Bi-Profenid tablets.

Adolescent↗
PubMed1982

[Pirprofen in the treatment of rheumatoid arthritis].

The efficacy and tolerance of pirprofen and ketoprofen in rheumatoid arthritis were compared in a cooperative, double-blind, cross-over trial involving 124 patients. Pirprofen 600 mg/day and ketoprofen 300 mg/day were given one after the other in a random order for two consecutive weeks. One hundred and ten patients were evaluated. Both drugs were comparable in efficacy, as evaluated on 12 different clinical and biological criteria with a tendency toward superiority for pirprofen. Pirprofen was very well tolerated by 79% and ketoprofen by 72% of the patients. Most of the side effects encountered were digestive disorders. In patients who received no other concomitant treatment, pirprofen was better tolerated than ketoprofen. Side effects were noted in only 9% of the patients under pirprofen, as against 25% under ketoprofen.

Adult↗
PubMed1978

[The failures of D penicillamine].

On the basis or a study of 50 cases of rheumatoid polyarthritis treated with D penicillamine comments are made on the failure of this form of treatment by comparison of the apparent and real efficacy. Taking account of withdrawals the percentage of true success is no more than a quarter of the patients treated with D penicillamine. Failure are due to overall inefficacy, dropouts from treatment and intolerance. The practical data on the indications and contra-indications of treatment, its conduct and supervision are defined.

Adolescent↗
PubMed1977

[A test for acute hypocalcemia using swine and salmon calcitonin].

The production of acute hypocalcemia was investigated using either 80 U. MRC of salmon calcitonin or 160 1. mrc of pork calcitonin in 117 subjects (58 patients with Paget's disease, 22 with osteoporosis, 22 with Sudeck-Leriche algodystrophy and 15 control subjects). The results obtained with the two types of calcitonin did not differ. Induced acute hypocalcemia was more pronounced in patients with Paget's disease than in the other subjects studied. In patients with Paget's disease there were statistically significant correlations between the hypocalcemia produced and the initial levels of alkaline phosphatase and total 24 hours urinary hydroxyproline.

Acute Disease↗
PubMed1976

A clinical study of ketoprofen suppositories.

Ketoprofen administered via the rectal route seemed to be valuable when given at night to patients with various rheumatic syndromes and may be particularly useful for patients who show gastric intolerance of the capsules. Anal intolerance was noted in 12% of the patients.

Anti-Inflammatory Agents↗
PubMedDate not supplied

[Clinical study of benorilate. Co-ordinated multi-centre test (author's transl)].

During a co-ordinated test realized by four centres of rheumatology, 91 patients had been treated by benorilate,giving so the possibility to appreciate its efficiency and its tolerance as well in the articulary fits of degeneration as in the inflammatory rheumatisms. The observations had been collected during ambulatory treatments and consequently in the conditions of daily practice. The efficiency of benorilate has been estimated by the two big disadvantages of the rheumatic person: importance of pains and capacity to do principal movements of daily life. The almost totality of patients having been preliminarily treated by another anti-inflammatory and/or antalgesic, the judgement aimed at the amelioration given by the benorilate : 41% of patients affected by arthropathy of degeneration feeled better or much better after taking benorilate. The amelioration reaches 61% for cases of rheumatoid polyarthritis. About the four criterions which could have been numerically quoted, the amelioration that had been observed is statistically significant. No anomaly had been pointed out as for the biological tolerance. The suspension form is well accepted by the rheumatic persons.

Adult↗