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Biomedical subjects

C B Brown

Publications and source records attributed to C B Brown.

At least 163 records · Page 9Linked to original sources
PubMed1967

Circadian rhythms of liver enzymes and their relationship to enzyme induction.

Tyrosine alpha ketoglutarate transaminase, which is rapidly induced by various agents, shows circadian rhythmicity in the intact rat. This rhythmicity is only slightly altered after adrenalectomy, indicating that adrenal hormones do not play a major role in the metabolic control of the activity of tyrosine alpha ketoglutarate transaminase. On the other hand, phenylalaninepyruvate transaminase, which is not inducible over the same time period, does not show circadian variation. The results suggest that the sensitivity of an enzyme's regulating system to inducing agents may be related to the inherent circadian rhythm of the enzyme.

Adrenalectomy↗
PubMedDate not supplied

Fluid dynamics in man of an intraperitoneal drug delivery solution: 4% icodextrin.

Interest in targeting drugs into the peritoneal cavity for intra-abdominal cancers or infections is undergoing a revival as recent clinical trials have demonstrated, not only a regional advantage in concentration of the active agent, but also improved long-term outcomes. Solutions currently used for intraperitoneal (IP) drug delivery have short residence times, however, which can limit the exposure of all areas of the peritoneum to the active agent. Icodextrin 4% solution was compared with saline and a glucose-based peritoneal dialysis solution in a clinical study of IP residence time. The study was carried out during the fortnightly rest phase in 9 patients undergoing 5-fluorouracil (5-Fu) IP treatment for colorectal cancer. The volume remaining in the peritoneal cavity was measured at 0, 12, 24, 48, 72, and 96 hr after an instillation of 2 liters of each fluid. Saline (n = 3 dwells) and glucose (n = 3 dwells) peritoneal dialysis solutions were almost fully absorbed by 24 hr, and the patients experienced discomfort when using these solutions. In contrast, icodextrin 4% solution (n = 188 dwells) maintained its instilled volume for up to 48 hr, and half the instilled volume remained after 72 and 96 hr. This result would allow extensive and prolonged coverage of the peritoneal surface. Icodextrin 4% solution may be an effective vehicle to deliver therapeutic agents into the peritoneal cavity.

Aged↗
PubMedDate not supplied

Membranous nephropathy long-term follow-up and association with neoplasia.

A ten years follow-up has been made on 66 patients with membranous glomerulonephritis. Eighty per cent of them showed nephrotic syndrome, one third elevated diastolic pressure and in 50% of the patients the GFR was reduced. Histopathologic stating and evolution were made as described by Ehrenreich histology with clinic and prognosis. Seven of 76 cases (11%) showed association with neoplasia; different pathogenetic hypothesis could be risen by this observation. The five year survival was 84% and the ten year survival about 50%. Increasing age and the presence of nephrotic syndrome mainly contribute to a poor prognosis.

Adult↗