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Biomedical subjects

C B Humphrey

Publications and source records attributed to C B Humphrey.

7 recordsLinked to original sources
PubMed1990

Cardiovascular and sensory responses to forearm ischemia and dynamic hand exercise.

The relationship between cardiovascular responses and pain produced by the submaximal-effort tourniquet procedure was evaluated in healthy humans. Graded increases in ischemic pain were associated with graded elevations in arterial blood pressure, forearm vascular resistance, and venous tone. Many of the vascular responses to muscle ischemia were typical of the cardiovascular components of the defense reaction and correlated with both the sensory and affective aspects of ischemic pain. The cardiovascular responses to arm ischemia were distinguishable from those produced by rhythmic hand exercise used to produce ischemia. Dynamic hand exercise produced a transient increase in arterial blood pressure, heart rate, and measures of hand discomfort. These responses were enhanced when dynamic hand exercise was conducted under ischemic conditions. The tightly coupled and coordinated cardiovascular responses elicited by ischemic pain represent integrated adaptive responses to painful stimulation.

Adult↗
PubMed1979

Gas pocket causing pacemaker malfunction.

Pacemaker malfunction was attributed to the increase in impedance to current flow caused by a pocket of air separating the anodal contact plate of a unipolar generator from the overlying skin. Lack of capture was noted 20 hours after implantation. The malfunction was permanently corrected by bedside aspiration of the gas with a sterile syringe.

Air↗
PubMed1977

Mediastinal teratoma masquerading as idiopathic enlargement of the right atrium.

A chest roentgenogram of an asymptomatic 22-year-old man revealed prominence of the right heart border characteristic of idiopathic dilatation of the right atrium. On further evaluation, a malignant teratoma was found. The importance of including teratoma and idiopathic enlargement of the right atrium in the differential diagnosis of abnormalities of the right heart border is discussed.

Adult↗
PubMed1976

An analysis of direct and indirect measurements of left atrial filling pressure.

Left ventricular function may be assessed by direct catheter measurements of left atrial pressure or by indirect measurements of pulmonary artery wedge pressure or pulmonary artery end-diastolic pressure. Controversy exists as to how closely the indirect measurements correlate with true left atrial pressure and to which is the most accurate. To clarify this probelm, we studied 43 patients undergoing cardiac surgical procedures with cardiopulmonary bypass. Both left atrial catheters for direct measurement and Swan-Ganz catheters were placed at the time of surgery. All patients were monitored continuously for 48 hours and hourly measurements were recorded. The resultant 1,620 left atrial pressure and pulmonary artery wedge pressure figures and 1,860 left atrial pressure and pulmonary artery end-diastolic wedge pressure measurements were subjected to computer analysis. The following conclusions have been found: (1) Pulmonary artery wedge pressure is a better indirect measure of left atrial pressure than is pulmonary artery end-diastolic wedge pressure (pooled correlation coefficient 0.629); (2) direct left atrial pressure measurement is more reliable and has fewer complications than indirect measurements; (3) there is no consistent correlation between left atrial pressure and central venous pressure (pooled correlation coefficient 0.3). A discussion of our results and the problems associated with left atrial catheters and Swan-Ganz catheters is presented.

Atrial Function↗
PubMedDate not supplied

Arteriovenous fistula of internal mammary artery after median sternotomy.

A female patient who had undergone median sternotomy for coronary artery bypass was found to have a continuous murmur on examination one month postoperatively. An arteriovenous fistula involving the right internal mammary artery, thymic, and second intercostal veins was diagnosed with selective angiography. An attempt at embolization of the fistula failed. Therefore, ligation and excision of the fistula was carried out. The etiology was attributed to parasternal wire placement during closure of the median sternotomy.

Arteriovenous Fistula↗