Biomedical subjects
C B Moore
Publications and source records attributed to C B Moore.
Psoralen-DNA photoreaction: controlled production of mono- and diadducts with nanosecond ultraviolet laser pulses.
Samples of DNA which contain adducts of a new psoralen derivative, but no cross-links, have been prepared by irradiating mixtures of DNA and the derivative with single, 15-nanosecond pulses of laser light. Succeeding pulses introduce cross-links. The ability to rapidly and selectively create monoadducts and corss-links may allow the use of psoralens as probes of dynamic processes in living cells.
Coronary artery bypass for acute myocardial infarction.
Coronary artery bypass has been done on 20 patients for acute mmyocardial infarction associated with shock, arrhythmia, and/or cardiac arrest. Twelve had had catheterization before the time of infarction. There were 3 hospital deaths, 2 late deaths, and 15 survivors. Survivors are angina-free and active 4 to 40 months postoperatively. Five patients have been recatheterized since operation, and in 4 all grafts are patent and functioning. Ventricular function was not improved in one patient, has remained the same in one, and improved in 3 patients. Although the time interval from infarction to revascularization is important, success is just as dependent on the patient's existing coronary collateral circulation. Lesions of the left main coronary artery were associated with the highest mortality. The rationale for operation in patients with acute myocardial infarction is to revascularize the marginal myocardium adjacent to the infarct and other underperfused areas when indicated. Chance for survival may thereby be increased by improvement of cardiac pumping or reversal of cardiac arrest or arrhythmia.
The sick sinus syndrome: treatment by permanent transvenous atrial pacing (a new approach).
"Sick sinus syndrome" is characterized by alternating tachyarrhythmias and bradyarrhythmias, diverse origin, generalized conduction abnormalities, and symptoms of heart failure, systemic embolization, and syncope. Proper treatment requires demand atrial or ventricular pacing. A patient with this syndrome was treated with a new transvenous atrial electrode catheter which has successfully controlled her symptoms for 33 months with unrestricted physical activity and without further paroxysms of atrial arrhythmia.