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Biomedical subjects

C B Swezey

Publications and source records attributed to C B Swezey.

5 recordsLinked to original sources
PubMed1984

Liquid chromatographic determination of lidocaine in serum.

A method is described for the quantitation of lidocaine in serum by high performance liquid chromatography (HPLC). The analysis utilizes UV detection at 210 nm with a Whatman ODS-3 5-micron analytical column and reverse phase precolumn held at 60 degrees C. The mobile phase consists of acetonitrile, potassium dihydrogen phosphate buffer, phosphoric acid and water. One hundred microlitres of serum sample are required and the analysis time is rapid, at eight minutes. Serum extraction is a two-step process using chloroform, sodium carbonate and hydrochloric acid. This method provides selectivity and sensitivity with a precision of 2.0%, recovery of 97.4%, average accuracy of 98.6% and no interference from eighteen commonly administered drugs.

Arrhythmias, Cardiac↗
PubMed1984

Determination of disopyramide phosphate in serum by high-performance liquid chromatography.

A method is described for the quantitation of disopyramide phosphate (Norpace) in serum by high-performance liquid chromatography. The analysis utilizes ultraviolet detection at 254 nm with a 5-micrometers reversed-phase column and a mobile phase consisting of acetonitrile, ammonium dihydrogen phosphate buffer, acetic acid, and water. The determination requires 100 microliters of serum sample and the analysis time (9 min) is rapid. Serum extraction is a two-step process using chloroform, sodium carbonate, and hydrochloric acid. Although acid is used, columns produced sharp peaks with consistent retention times for 6-8 months. This method provides selectivity and sensitivity with a precision of 3.8%, average recovery of 92.9% and no interference from 18 commonly administered drugs.

Chromatography, High Pressure Liquid↗
PubMed1981

Computer-based calibration of the DuPont ACA II.

Desk-top computers equipped with 16K memory and programmed in BASIC can be used to produce calibration calculations for the DuPont ACA II. Entries are made by the operator in accordance with the ACA-supplied calibration format and results may be displayed on a video screen and/or programmed for hard copies to be produced by the use of an interfaced line printer. The operator is provided with the option of computing the Y-intercept from a hand-drawn graph, or allowing the computer to calculate it from the slope. The final printout supplies the averages necessary for plotting the calibration curve, slope and intercept of the line, new intercept, new starting point, and new scale factor. The calibration involved on the ACA II is time-consuming and frequently may produce mathematical errors, both of which are eliminated by the use of the described computer program.

Calibration↗
PubMed1980

Computer-based diagnostic reporting for serum electrolytes.

Desk-top computers equipped with 16K memory and programmed in BASIC can be used to produce interpretive reports of selected laboratory data by the assignment of a numerical code. A tetral algorithm is programmed in a three-dimensional matrix, charted by columns designating specific diagnostic considerations for serum electrolyte abnormalities (an adaptation of Dito's coding procedure for protein electrophoresis). The code consists of the numbers 4 (high), 2 (normal), and 1 (low), with no basis for borderline abnormal results. The program is easily updated with additions of diagnostic considerations (column headings) or with additional codes corresponding to such conditions (code listings under column headings). Diagnostic reports can be easily produced by the use of a tractor-feed printer or similarly interfaced printing equipment for use on the patient chart, and file copies are easily generated by a "rerun" loop incorporated into the software.

Acid-Base Equilibrium↗