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Biomedical subjects

C B Tuttle

Publications and source records attributed to C B Tuttle.

6 recordsLinked to original sources
PubMed1985

Drug management of pain in cancer patients.

Chronic severe cancer pain is often not well controlled because both patient and physician have a poor understanding of the nature of the pain and of the actions of various potent analgesics. Physicians often fail to tailor analgesic dosages to the needs of the individual and unnecessarily limit the dosage because they have an ill founded fear that the patient will become addicted. The basis of rational management of cancer pain with drugs is an appropriate analgesic given regularly in doses adequate to suppress pain continuously. This review compares the potent analgesics and identifies and discusses those that have a role in treating chronic cancer pain. It emphasizes the value of morphine sulfate and gives information on starting and individualizing dosages and managing side effects.

Administration, Oral↗
PubMed1984

Guidelines for phenytoin infusions.

Until recently, phenytoin sodium injection was not recommended for dilution in intravenous fluids because insolubility results in precipitation of phenytoin acid. The formation of rod-shaped crystals primarily reflects the failure to maintain the pH of the admixture above 9.5 to 10. Investigations have clarified this problem and point out that stable solutions of phenytoin sodium can be prepared which are safe for intravenous infusion provided the injection is diluted in small volumes of 0.9 percent sodium chloride or Ringer's. Lactate injection and administered freshly prepared. Specific guidelines are suggested for the preparation and administration of phenytoin sodium infusions.

Drug Compounding↗
PubMed1977

Intramuscular injections and bioavailability.

Bioavailability of drugs following intramuscular injection is reviewed, with particular emphasis on diazepam, chlordiazepoxide, phenytoin, digoxin and lidocaine. Clinical experience with these drugs has shown that i.m. absorption may be slow, erratic or incomplete. Factors which play a role in the bioavailability of i.m. medications include the water solubility of the drug, dispersion of the injected solution and blood flow at the muscle site. For many drugs, intravenous injection is the parenteral route of choice, and oral administration may be more efficacious than i.m. injection.

Absorption↗