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Biomedical subjects

C B Yu

Publications and source records attributed to C B Yu.

11 recordsLinked to original sources
PubMed2003

Bacteriocidal effects and inhibition of cell separation of cinnamic aldehyde on Bacillus cereus.

AIMS: In this study, bacteriocidal effects of cinnamic aldehyde on Bacillus cereus were investigated. METHODS: The bacterial culture or cell suspension in 0.85% NaCl was treated with cinnamic aldehyde at a concentration of 0.3 ml l(-1). Viable cells were counted on a nutrient agar plate. Protein leakage from the cell was determined using a protein dye. Cell morphology was observed using a scanning electron microscope. RESULTS: Bacillus cereus cells were the most sensitive to cinnamic aldehyde among four different food-borne pathogens. When the cells were treated with 0.3 ml l(-1) of cinnamic aldehyde, the viable counts decreased about 6 log cycles after 6 h of incubation. The bacterial cells remained unlysed although they were killed by cinnamic aldehyde. Treatment of cinnamic aldehyde to the exponential phase cells resulted in no significant protein leakage but strong inhibition of cell separation. CONCLUSIONS: The present findings suggest that cinnamic aldehyde exhibits bacteriocidal effects and inhibition of cell separation on B. cereus. SIGNIFICANCE AND IMPACT OF THE STUDY: These data represent an interesting background for a possible mechanism for antibacterial effects of cinnamic aldehyde.

Acrolein↗
PubMed2001

Effect of carbon source on the mycelial growth and exo-biopolymer production by submerged culture of Paecilomyces japonica.

A significant difference was observed in the production pattern of exo-biopolymer and broth rheology during submerged culture of Paecilomyces japonica when two efficient carbon sources (maltose and sucrose) were employed. The maximum concentration of biopolymers in maltose medium (30 g/l) was higher than that in sucrose medium (25 g/l), whereas maximum mycelial concentration displayed an inverse result (i.e., 25 g/l in sucrose medium and 20 g/l in maltose medium). The broth rheology and morphology of P. japonica were also markedly different between the two culture media.

Journal Article↗
PubMed2000

Fornix-based trabeculectomy with Wise's suture technique in Chinese patients.

OBJECTIVE: To assess the safety and efficacy of fornix-based trabeculectomy with Wise's suture technique in Chinese subjects. DESIGN: A retrospective noncomparative case series. PARTICIPANTS: Forty-eight eyes of 44 Chinese subjects that underwent fornix-based trabeculectomy combined with intraoperative 0.4 mg/ml mitomycin-C for 3 to 5 minutes were studied. INTERVENTION: Conjunctival wound closure of all eyes was with the Wise's technique using 9-0 nylon suture to prevent leakage at the corneolimbal interface. MAIN OUTCOME MEASURES: The success rate, with or without antiglaucoma medication, the complication rate, and the longevity of the drainage blebs were analyzed. RESULTS: At a mean follow-up period of 21.8 +/- 4.5 months, 75% (36 eyes) had postoperative intraocular pressure of 21 mmHg or less. Of these, 23 eyes (47.9%) required no antiglaucoma medication, 7 eyes (14.6%) required one medication, 3 eyes (6.3%) required two medications, and 3 eyes (6.3%) required three medications. Ten eyes (21%) had early wound leak. Two eyes (4.2%) required surgical repair. Two eyes (4%) had hypotonous maculopathy. No other major complications were encountered. CONCLUSIONS: Fornix-based trabeculectomy with adjunctive mitomycin-C using Wise's suture technique appears to be both safe and effective in Chinese subjects.

Antimetabolites, Antineoplastic↗
PubMed1996

Long-term results of combined cataract and glaucoma surgery versus trabeculectomy alone in low-risk patients.

PURPOSE: To compare the long-term results of combined extracapsular cataract extraction (ECCE), intraocular lens (IOL) implantation, and trabeculectomy with those of trabeculectomy alone in low-risk patients. SETTING: An ophthalmic department in a British general district hospital. METHODS: We did a retrospective analysis of the case records of all low-risk patients who had either combined ECCE, IOL implantation, and trabeculectomy (combined group) or trabeculectomy alone between August 1991 and February 1993 with a minimum of 12 months follow-up (mean 21 months). The combined group comprised 21 patients (14 women) and the trabeculectomy group, 24 patients (18 women). The mean ages were 79.8 years (range 66 to 90 years) and 76.0 years (range 61 to 87 years), respectively. We measured final intraocular pressure (IOP), number of medications used, best corrected visual acuity, visual field, and complication rates. RESULTS: Average IOPs at diagnosis, the preoperative visit, and last follow-up visit were 27.6, 23.1, and 15.6 mm Hg, respectively, in the combined group and 31.8, 26.7, and 15.3 mm Hg, respectively, in the trabeculectomy group. The differences between groups were not statistically significant at any stage. All patients had an IOP lower than 22 mm Hg at the last follow-up. In more than 75% of patients in the combined group, visual acuity improved by more than one Snellen line. CONCLUSIONS: The combined procedure compared favorably with trabeculectomy alone in low-risk patients.

Aged↗
PubMed1985

Dose finding double-blind clinical trial with praziquantel in schistosomiasis japonica patients.

A double-blind clinical trial with praziquantel was carried out. A total of 400 cases was treated with four different dosages, namely, 60, 50, 40 and 30 mg/kg body weight of praziquantel. The drug was given in one day divided into two doses. Identical placebo tablets were used to make up a total of 60 mg/kg. Tolerance was good in all with the exception of one case suffering from asthmatic attack with papule rashes over large area of the body surface. 394 patients were able to be followed up parasitologically six months post-treatment. 79.8%, 71.7%, 78.8% and 70.1% of the patients were negative in the groups with the total dose of 60, 50, 40 and 30 mg/kg respectively. The cure rates as well as the side effects were similar for the four groups. The efficacy was lower than that reported by other authors and the possibility of reinfection was incriminated. In villages with few snails the negative hatching rates in aforementioned four groups were 89.1%, 91.1%, 88.9% and 81.8%, while in villages with abundant snails the rates were 68.2%, 46.5%, 66.7% and 54.8%. The difference between the two areas was statistically significant. Higher efficacy was observed in adults with an average cure rate of 80.0% than in children under 15 years of age, the average cure rate being 57.1%.(ABSTRACT TRUNCATED AT 250 WORDS)

Adolescent↗