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C Börnke

Publications and source records attributed to C Börnke.

13 recordsLinked to original sources
PubMed2004

Differential response in choice reaction time following apomorphine based on prior dopaminergic treatment.

Choice reaction time (CRT) paradigms demonstrated deficits in the preparation and execution of movements in patients with Parkinson's Disease (PD). Predominantly these trials did not consider an influence of acute and long-term dopaminergic substitution. Objective was to determine the acute effect of apomorphine on the response to a repeatedly performed CRT task. We repeatedly executed the CRT paradigm before and after subcutaneous apomorphine injection in previously treated, untreated and long-term dopamine substituted PD patients, who took placebo. No significant change of CRT and movement time (MT) appeared in PD patients with chronic dopaminergic drug intake after apomorphine injection. CRT and MT both significantly worsened in untreated PD patients. Placebo application induced no significant alteration. Binding of apomorphine to presynaptic autoreceptors with subsequent sedation or inhibition of locomotor activity hypothetically explain our results in before untreated PD patients. Previous long-term dopaminergic substitution may cause a certain tolerance to this phenomenon.

Adult↗
PubMed2003

Neurophysiological findings in SPG4 patients differ from other types of spastic paraplegia.

The authors examined 12 families with autosomal dominant hereditary spastic paraplegia for phenotypic characteristics predicting the underlying genotype. They found no clinical differences between patients with or without mutations in the spastin gene (SPG4). Motor evoked potentials and nerve conduction studies were almost normal in those with SPG4. In contrast, non-SPG4 families had prolonged central motor conduction times or marked peripheral neuropathy, or both.

Adenosine Triphosphatases↗
PubMed2003

Repeated rating improves value of diagnostic dopaminergic challenge tests in Parkinson's disease.

Clinicians use acute challenges with levodopa (LD) and/or apomorphine (A) for diagnostic dopaminergic response tests in Parkinson's disease (PD) patients. We consecutively compared the value of both drugs with performance of repeated ratings and adverse effect recording. Oral administration of 200 mg LD was superior to subcutaneous injection of 4 mg A in terms of tolerability and onset of temporary UPDRS motor score decline ([previously untreated PD patients] LD: 4.02 [mean] +/- 2.45 [SD] [significant decrease: p = 1.42 E-07] vs. A: 1.58 +/- 3.38 [not significant decrease: p = 0.14], p = 0.0009; [treated PD patients] LD: 7.71 +/- 4.35 [significant decrease: p = 2.48 E-06] vs. A: 5.19 +/- 4.32 [significant decrease: p = 7.83 E-05], p = 0.07). We suggest diagnostic acute challenge test performance with LD as first- and A as second choice due to better tolerability and valuation in combination with repeated scoring procedures to improve sensitivity and specifity.

Administration, Oral↗
PubMed2002

Vertebral body infarction indicating midthoracic spinal stroke.

STUDY DESIGN: Case report. OBJECTIVE: To illustrate the significance of vertebral body infarction as the only confirmatory sign of spinal cord ischemic stroke. SETTING: Department of Neurology, St. Josef-Hospital, Bochum, Germany. CASE DESCRIPTION: A 65-year-old man presented with clinical features suggesting spontaneous spinal cord infarction in the territory of the left sulcocommissural artery at the level of Th 8. Sequential magnetic resonance imaging (MRI) investigations failed to demonstrate infarction of the spinal cord but T2-weighted images revealed bone marrow hyperintensities of vertebra Th 9 and 10 in their left and dorsal parts consistent with vertebral body infarction. CONCLUSION: In clinically presumed spontaneous spinal cord infarction and unremarkable signaling of the spinal cord during sequential MRI investigations vertebral body infarction may serve as the only confirmatory sign of spinal cord ischemic stroke.

Aged↗
PubMed2001

Delay of simple reaction time after levodopa intake.

BACKGROUND: Parkinsonian patients (PP) have deficits in the preparation and execution of movements. It is generally accepted that PP show delayed performance of simple reaction time (SRT) paradigms due to impaired response preprogramming. To date, no trial considered putative effects of dopaminergic substitution on SRT performance in PP. OBJECTIVES: To determine short-term effects of acute levodopa intake and impact of long-term dopaminergic substitution on the results of a SRT task. METHODS: We repeatedly performed a SRT paradigm in previously untreated- and treated PP, taken off medication for at least 12 h, before and after intake of levodopa/benserazide and in PP, who received placebo. RESULTS: Reaction time significantly increased and movement time did not change after levodopa intake. Placebo application showed no effects. CONCLUSIONS: Levodopa delayed cognitive processing and/or behaviour. Sedative effects of levodopa and/or dopamine overflow in prefrontal regions with subsequent cholinergic dysfunction hypothetically caused this phenomenon.

Adult↗
PubMed1998

Kleine-Levin syndrome and Parkinsonian symptoms--a case report.

We report the case of a 54-year-old male patient, who developed the symptoms of Kleine-Levin syndrome (KLS) at the age of fifty. Four years later Parkinsonian symptoms (PS) appeared. The possible relationship between both KLS and PS, e.g. regarding neuroendocrinological similarities, will be discussed to explain the subsequent onset of PS after the manifestation of KLS in this patient.

Humans↗
PubMed1997

Power Doppler compared to color-coded duplex sonography in the assessment of the basal cerebral circulation.

Power-based transcranial duplex sonography (p-TDS) is a new promising ultrasound technique that generates intravascular color signals from the amplitude of the echo signal. The present investigation was undertaken to determine the advantages and limitations of power Doppler in the assessment of the basal cerebral circulation compared with transcranial color-coded real-time sonography (TCCS) and contrast-enhanced transcranial color-coded real-time sonography (CE-TCCS). Thirty-eight patients without cerebrovascular diseases were examined with p-TDS and TCCS, and in 11 patients CE-TCCS studies were performed. The M1 segment could be identified in 100% by both ultrasound techniques. p-TDS visualized M2 (67/70 vs 46/70, p < 0.0001), A2 (63/70 vs 46/70, p < 0.001), and P2 (67/70 vs 44/70, p < 0.0001) segments significantly more frequently and accurately compared to TCCS. The posterior communicating artery (25/70) and P3 segments (32/70) were only detectable by p-TDS and not by conventional TCCS. In comparison with CE-TCCS, p-TDS had no important advantages in the detection of intracranial vessels. In conclusion, p-TDS and CE-TCCS were superior to TCCS with regard to identification of the basal arterial circulation. Both methods permit noninvasive and reliable identification of the basal cerebral circulation.

Adult↗
PubMed1996

[Secondary cerebral vasculitis in suppurative meningitis. Clinical aspects and findings in color-coded transcranial duplex ultrasound].

Transcranial Doppler ultrasonography carried out in cases of bacterial meningitis has often shown a reversible increase in blood flow velocity in basal cerebral arteries, that is interpreted as caused by segmental vasospasm brought on by vasculitis. We report for the first time on findings of transcranial colour-coded duplex ultrasonography performed on a patient with pneumococcal meningitis who suffered a subcortical infarction in the territory of the right middle cerebral artery. Doppler ultrasonography revealed an increase in blood flow velocity of the right middle basal cerebral artery, while the B-scan revealed thickening of the main trunk on the right. These findings suggest an inflammatory thickening of the blood vessel wall with secondary narrowing of the lumen as a result of secondary vasculitis.

Adult↗