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Biomedical subjects

C Ball

Publications and source records attributed to C Ball.

At least 19 recordsLinked to original sources
PubMed1995

Esmarch's mask.

Explore the source record for details and available documents.

Anesthesia, Inhalation↗
PubMed1992

Simultaneous partial monosomy 10p and trisomy 5q in a case of hypoparathyroidism.

We report a case of monosomy for the distal region of the short arm of chromosome 10 (p13----ter) associated with trisomy for the terminal region of the long arm of chromosome 5 (q35.2----ter) that had originated from adjacent 1 segregation of a maternal reciprocal balanced translocation (5;10)(q35.2;p13). We review the clinical findings of previously reported cases of both partial monosomy for 10p and of partial trisomy for 5q, but to our knowledge there are no previous reports of the effects of these two chromosome anomalies together. Clinically our patient showed features typical of partial monosomy for 10p (including hypothyroidism) rather than partial trisomy 5q.

Chromosome Aberrations↗
PubMed1991

Assay of pyrogens by interleukin-6 release from monocytic cell lines.

A novel in-vitro system has been developed for the detection and quantification of pyrogen in pharmaceutical products. The measured variable was evoked secretion of the pyrogenic cytokine interleukin-6 from MONO MAC 6 monocytic cells incubated with the product. The interleukin-6 was detected using a specific and sensitive ELISA developed for this purpose. The test system detected pyrogenic contamination in 3 batches of therapeutic human serum albumin which had caused adverse reactions in recipients. The contamination was not detected in conventional tests: the rabbit pyrogen test and the limulus amoebocyte lysate test.

Animals↗
PubMed1991

Endoscopic retrograde cholangiopancreatography in infantile cholestasis.

The difficulty of distinguishing surgically correctable causes of conjugated hyperbilirubinaemia in infants from other causes means that some infants may undergo laparotomy and intraoperative cholangiography unnecessarily, and others may be referred for surgery too late. In an attempt to improve the diagnostic accuracy in infants with conjugated hyperbilirubinaemia when standard methods produced equivocal results, we have been using prototype paediatric duodenoscopes (PJF 7.5 and XPJF 8.0; Olympus) to perform endoscopic retrograde cholangiopancreatography (ERCP). From 159 infants with conjugated hyperbilirubinaemia, 11 were referred for ERCP, which was performed in nine. In four in whom bile ducts were definitely visualised laparotomy was avoided. Operative cholangiography confirmed patent bile ducts in one in whom visualisation had been uncertain. Three of four in whom bile ducts were not seen had extrahepatic biliary atresia. Visible bile drainage in the fourth excluded atresia. No major complications ensued but there was radiological evidence of gall bladder perforation in one (common hepatic duct block) and overinflation with air was a problem until finer cannulae (Wilson-Cook) were introduced. In appropriately selected patients with conjugated hyperbilirubinaemia, ERCP with paediatric duodenoscopes in experienced hands may provide useful diagnostic information.

Biliary Atresia↗
PubMed1988

Functional residual capacity related to hepatic disease.

Functional residual capacity was measured in 20 children (aged 3.1-11.2 years) with liver disease. Children with severe liver disease, regardless of diagnosis, had reduced functional residual capacities (less than 80% of expected). Children with alpha-1 antitrypsin deficiency had higher functional residual capacities than those with other hepatic diagnoses. Three children had a functional residual capacity greater than 120% of expected, all had alpha-1 antitrypsin deficiency.

Child↗
PubMed1984

[Inflammatory lymphadenoid reactions around basocellular epitheliomas].

The histological study of 3,960 basal cell epitheliomas (carcinomas) showed in 82 cases (2 p. 100) an inflammatory lymphoplasmocytic reaction of the lymphadenoid type characterized by the neoformation of differentiated germinative centers. These organoid structures are morphologically similar to those of normal lymphoid follicles of the lymph-nodes and occur most often around the basal cell carcinomas of the face and the neck (96 p. 100), mainly the temporal and peri-auricular skin areas (37,5 p. 100). The concerned tumours are mostly of the primordial type (90 p. 100); such a lymphadenoid reaction was never observed around morphea-like basal cell carcinomas and seldom around superficial spreading basaliomas of the trunk. In 85 p. 100 of the examined cases the tumours were ulcerated and invaded the depth of the reticular dermis (78 p. 100) or the subcutaneous fat (6 p. 100). The occurrence of a lymphadenoid stromal reaction seemingly does not limit the tumour growth and in most cases it concerns aggressive and ulcerated ulcus rodens of histologically nodular or large trabecular type (solid, pseudo-cystic or adenoid variants). It could account for the possible inhibition of the host T-cell mediated immune defense by the aggressive behaviour of the tumour and the induction of a B-lymphocytic secreting reaction with no evident efficiency on the proliferative pattern and activity of the tumour. Its prevalent occurrence around basal cell carcinomas of peri-auricular localization could be related to lymphopoietic remnants of this skin area.

Adult↗
PubMed1983

Management of acute brachial artery occlusion due to trauma or emboli.

Out of 37 patients requiring emergency surgery for upper limb ischaemia, 9 were due to spontaneous embolus, 7 to arterial laceration and 21 followed cardiac catheterization. Eleven of the initial operations (30 per cent) failed to relieve ischaemic symptoms though 6 were corrected by further operations. Success at the initial operation was associated with (i) repair with end-to-end anastomosis after resection, saphenous vein bypass or interposition graft, or generous vein patch, (ii) exposure of the radial/ulnar bifurcation, (iii) instillation of heparinized saline locally or (iv) restoration of the radial pulse at the end of the operation. In the cases studied in whom all the above recommendations were followed, the operation was entirely successful and all patients have a radial pulse and are currently symptom free.

Acute Disease↗
PubMed1983

Characteristics of colon cancer patients reported in population-based tumor registries and Comprehensive Cancer Centers.

The characteristics of colon cancer tumors diagnosed in patients seen at hospitals participating in the National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) Program and at Comprehensive Cancer Centers (CCC's) belonging to the Centralized Cancer Patient Data System (CCPDS) are compared. There were identified among cases diagnosed between July 1, 1977 and December 31, 1978, the first 18 months of registration for the CCPDS centers. A higher proportion of CCPDS colon tumors were diagnosed in black patients, 15.4% versus 6.8% for SEER, reflecting the urban location of many CCC's. The CCPDS has proportionally fewer patients aged 75 years or older, and a median age of 67.5 years versus 70 years for the SEER cases. Although surgery alone was the major form of therapy for both CCPDS and SEER patients with colon tumors, higher percentages of CCPDS patients than SEER patients were treated by chemotherapy alone or by modalities other than surgery, chemotherapy, and radiotherapy, particularly those with later stages of the disease. Few disagreements existed between the 2 groups in distribution by segment of the colon, stage, and histologic type. Few differences were found that would render invalid future comparative analyses of patient survival between the two data systems once adequate follow-up information is available. Such an evaluation may be a valuable instrument in measuring whether improvements in cancer patient management being developed at CCC's are, in fact, "filtering down" to the general series of colon cancer patients.

Adult↗
PubMed1980

A discussion of microbial genetics in fermentation process development with particular reference to fungi producing high yields of antibiotics.

When trying to improve antibiotic processes that are already high yielding, real industrial problems have to be faced. These include the use of organisms with non-ideal growth and recombination cycles, and problems of scale up from the laboratory to the main production plant. Many of the principles derived from academic studies have to be radically modified before they can be applied in the industrial context. These issues are a challenge to those who genuinely wish to contribute to the solution of industrial problems.

Anti-Bacterial Agents↗