[The association between ankylosing spondylitis, Crohn's disease and HLA-B27. A study of seven patients].
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Adult↗
Biomedical subjects
C Barrios
Publications and source records attributed to C Barrios.
Determinants of infant responses to vaccines in presence of maternal antibodies.
Presence of maternally-derived antibodies at time of immunization is known to often interfere with active infant immunization, although with variable degrees of clinical significance. In order to progressively decipher the rules that form the basis for these inhibitory effects on infant vaccine responses, two antigens (measles, tetanus) and various antigen presentation systems were evaluated in murine early life immunization models either in absence or presence of maternal antibodies. Both conventional (proteins, conjugate vaccines) and new (live viral vectors, DNA plasmids) antigen presentation systems were found to be similarly susceptible to the inhibitory influence of maternal antibodies. Factors emerging as crucial determinants of maternal antibody-mediated effects on responses to both live and non-live vaccines include (i) the level of maternal antibodies present at immunization, (ii) the use of distinct vaccines in mothers and pups and (iii) their distinct influence on B cell and T cell vaccine responses.
Animals↗
Longitudinal growth pattern of the radius after forearm fractures conservatively treated in children.
In a 3-year prospective study, the growth pattern of the radius following fracture was analyzed in 64 children < 15 years old with forearm fractures treated by conservative methods. Comparative radiographic studies of the fractured and the uninjured radius were carried out in all patients at 3, 6, 12, and 18 months after fracture. Only 40 patients, 28 boys and 12 girls, with an average age of 9 years, completed the follow-up period. The series included 19 buckle fractures of the radius, 11 green-stick, and 10 complete fractures. Fracture of the ulna was associated in 11 cases. Maximal average radial growth rate was observed from age 9 through 12 years. Overall, the length discrepancy between the fracture and the healthy radius at the end of the follow-up period averaged 0.03 cm (range -0.50 to +1). In nine cases (21%), the fractured radius showed an average overgrowth of +0.44 cm. In 10 other patients (25%), a radial shortening could be detected (average discrepancy -0.29). Five of the nine cases with radial overgrowth had an associated fracture of the ulna. This association was not found in any of the 10 patients with radial shortening. These observations allow us to reconsider the classic etiopathogenic theories concerning overgrowth in the long bones of children following fracture. Factors other than the increased vascularity of the growth plate--as is postulated for the femur and tibia--must be investigated further to explain the frequent absence of radial overgrowth following fracture.
Adolescent↗
Amplification of the c-myc proto-oncogene in soft tissue sarcomas.
Soft tissue sarcoma fresh specimens from 23 patients were screened for genetic abnormalities of 3 cellular oncogenes, i.e., c-myc and c-myb and c-Ha-ras. Southern blot hybridization analysis demonstrated amplification of the c-myc gene (4- to 8-fold) in 7 cases, i.e., 3 malignant fibrous histiocytomas, 1 liposarcoma, 1 fibrosarcoma, 1 lymphoma of the soft tissues and 1 synovial sarcoma. Amplification of the c-myc gene was not associated to other genetic alterations such as gene rearrangement. Hybridizations with c-myb and c-Ha-ras probes showed no gene abnormalities in this series. Our results indicate that c-myc oncogene amplification may play an important role in the development of certain soft tissue sarcomas as it has been found for other human malignancies. The clinical significance of these features remains to be established.
Adult↗
[Adenomatous polyps in colon and rectum after cholecystectomy].
The frequency of rectal and colonic polyps was compared in 33 patients with history of cholecystectomy and 37 patients without it. The data were evaluated retrospectively from our medical bank records. We found a major incidence of adenomatous polyps in the group of patients with cholecystectomy, the same in females as in males, with a female prevalence in 2.7:1 ratio in contrast with the group without surgery, where the ratio was 1.5:1 with a male prevalence. We didn't find any association between cholecystectomy and colorectal cancer. All the patients with adenocarcinoma were in the group without cholecystectomy.
Adenocarcinoma↗
[Gastric cancer and routine upper digestive endoscopy].
In this paper we analyzed 5,401 upper G.I. endoscopies performed in a period of 5 years (1985-89), in the Gastroenterology Service at Hospital Jesús Yerena, in Caracas, Venezuela. We found 53 cases of stomach cancer, only 2 of them were early gastric cancer. We studied personal and epidemiological data, symptoms, place of the lesion, treatment, surgical mortality, macroscopic morphology and histopathology. We discuss the results concluding that: cancer of the stomach is a prevalent disease in our Hospital; that fibrogastroscopy is a very good diagnostic procedure; that we must organize a Program of Early Detection for this disease and that we should improve the Oncological Register.
Adenocarcinoma↗
[Gastric epithelioid leiomyosarcoma (malignant leiomyoblastoma). Report of a case and review of the world literature].
The authors report a case of gastric epithelial leiomyoma. (Leiomyoblastoma). Macroscopically, such tumors resemble leiomyoma, with a biological behavior between leiomyoma and leiomyosarcoma. A review of the medical literature indicates that gastrointestinal bleeding in the most usual manifestation. The endoscopy biopsy, many times, is unable to confirm the malignant or benign of the tumor. It is emphasized the importance of identifying the potentially malignant tendency of the tumor, indicated, mainly, by histology consist in total gastric resection. Radiology, Ultrasound and Endoscopy are the most frequently used methods to arrive at diagnosis. In our case a patient with a presumed diagnosis of gastric cancer with a severe upper gastrointestinal hemorrhage was operated on as an emergency. A radical extended total gastrectomy was performed. Intraoperative findings included multiple pancreatic, hepatic, splenic, hilium, greater and lesser omental metastases. The patient was released in good condition but died 3 months later.
Biopsy↗
Surgical management of nerve injuries of the upper extremity in children: a 15-year survey.
In a 15-year retrospective study, the results of 37 surgically treated nerve lesions of the upper extremity in 33 children were reviewed after a mean follow-up of 2 years. Children ranged in age from 4 to 15 years. There were 19 ulnar, 12 median, and 6 radial nerve injuries. Discontinuity of the nerve trunk was found in 23 patients operated by interfascicular grafting (18 patients) or epineural suture (5 patients). The other 14 lesions were treated by decompressive external neurolysis. Useful sensory function (S4-S3) assessed at the autonomous zone was restored in 31 patients (84%). Satisfactory motor recovery was achieved in 25 patients (67%). Independent of the type of lesion, the median nerve showed the best ability to regain complete motor and sensory function. In lesions with continuity of the nerve trunk, those affecting the radial nerve had a worse prognosis regarding motor function recovery. Unfavorable prognosis was mainly related to a time interval of more than 1 year between nerve damage and surgery.
Adolescent↗
[Early management of foreign bodies in the upper digestive tract with flexible fiberendoscopy].
We present our five year experience (1983-1988) in 74 patients who intentionally or accidentally ingested foreign bodies, and their management with flexible fibroendoscopy. A higher incidence was observed in children under 6 years of age, and adults between 30 and 50 years of age. The major presenting symptom was the "sentation of foreign body", and 24% of patients presented no symptomatology. The most commonly encountered foreign bodies were: fishbone, coins, chicken bones, and meat fragments. An esophageal location was the most commonly found, predominantly in the proximal third. Flexible endoscopy performed in 59 patients (80%), successfully removing the foreign body in 93.2%. In the remaining cases it was demonstrated previously that the foreign body could not be reached by the endoscope.
Adolescent↗
Expression of c-myc in canine mammary tumours.
The expression of the protooncogene c-myc was examined in twelve canine mammary tumours of different histological type. Only in one tumour--a poorly differentiated carcinoma--was the amount of RNA that hybridized with our cDNA probe for the myc gene significantly increased. Restriction fragment length analysis of genomic DNA from this tumour did not reveal any amplification or other rearrangements in this gene locus.
Animals↗
Expression of the myc protooncogene in canine rhabdomyosarcoma.
The expression of the protooncogene c-myc in a canine rhabdomyosarcoma was examined. It was found that this highly malignant tumour contained vast quantities of RNA that hybridized with a cDNA probe for c-myc. Restriction fragment length analysis after endonuclease digestion of tumour DNA did not reveal any rearrangements in this gene locus. The potential role of this oncogene in the development of canine rhabdomyosarcoma is discussed.
Animals↗
[Normality patterns according to dimensional analysis of the pancreas, portal system and common bile duct by ultrasonics].
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Adolescent↗
Sporadic amplification of the c-fms proto-oncogene in human musculoskeletal sarcomas.
Fresh samples of bone and soft tissue sarcoma from 31 patients were analyzed by the Southern technique for amplification or other structural abnormalities of the c-fms oncogene. As a sole finding, amplification of the c-fms (4- and 10-fold) was detected in 2 of 3 cases with a histologic diagnosis of liposarcoma. RFLP analysis disclosed no gene rearrangements associated with the c-fms amplification. The case with the highest amplification of the c-fms gene was disease-free at review. The 2 fms-amplified liposarcomas were aneuploid according to DNA flow cytometry. This is the first study demonstrating amplification of the c-fms proto-oncogene in human liposarcoma. The fact that this structural abnormality of the c-fms gene was only detected in liposarcomas might point to an uncommon but tissue-specific phenomenon.
Blotting, Southern↗
Spinal cord and bone metastasizing renal tumor of childhood.
In recent reports on renal tumors of childhood with bone involvement neoplasms originally considered to be Wilms tumor have been assigned to new groups. After reviewing the literature, we knew that Wilms tumor rarely metastasizes in this way. Our case illustrates the unique biological feature of the rare, unfavorable histology Wilms tumor variant know as 'clear cell sarcoma of the kidney' (CCSK). Metastases to the spinal cord, as observed in our patient are distinctly unusual. To our knowledge, only two previous cases have been reported in the world literature.
Bone Neoplasms↗
Treatment of adolescent Blount disease by asymmetric physeal distraction.
An alternative treatment is presented for late-onset Blount disease in a 14-year-old boy. The technique consists of asymmetric physeal distraction of the proximal tibial growth plate by using a modified Wagner fixator-distractor device that allows progressive angular correction. The patient had a 23 degrees varus deviation of the left tibia, and no physeal bone bridges were detected. Once the fixator was assembled, distraction started 24 h after surgery at a rate of 1.5 mm/day (2 x 0.75). Complete correction was achieved in 25 days. No osteotomy of the fibula was required. The Wagner device was removed in the outpatient clinic 10 weeks postoperatively. After a 4-year follow-up, there was no loss of correction, showing a satisfactory alignment of the operated-on lower extremity. As compared with acute conventional osteotomies, asymmetric physeal distraction entails several advantages for treatment of Blount disease such as less invasive surgery, progressive and adjustable correction taking place at the apex of the deformity, and the possibility of bone lengthening if needed. Furthermore, physeal distraction does not require a second surgical step for bonegraft harvesting or for removal of the internal fixation.
Adolescent↗
[Congenital dilatation of the intrahepatic biliary tract].
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Adolescent↗