RUMMAGE--a high-throughput sequence annotation system.
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Biomedical subjects
Publications and source records attributed to C Baumgart.
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During interviews with physicians and nurses on the general pediatric intensive care unit (ICU) of the University of Heidelberg Children's Hospital personnel reported on various aspects of their work. One complex of questions dealt with the motivation to work in intensive medicine. Physicians and nurses showed different patterns of motivation. Physicians could be clearly divided into those who found intensive medicine fascinating and those who tended to fear it. Nurses' motivation is multifaceted and differentiated. The information gained from the interviews questions the sense of obligating physicians without interest or aptitude to rotate to an ICU during their specialty training in pediatrics. This policy is associated with corresponding risks for patients. The work of often superiorly qualified nurses becomes more difficult.
1. There are two 2,4-dienoyl-CoA reductases (EC 1.3.1.-) (formerly called 4-enoyl-CoA reductase, Eur. J. Biochem. (1978) 91, 533-544) in rat liver, one in mitochondria and another one in peroxisomes. 2. Treatment of rats with clofibrate increases the activities of the 2,4-dienoyl-CoA reductases in both cell organelles. 3. Isolated peroxisomes metabolize 4-cis-decenoyl-CoA, a metabolite of linoleic acid, via the 2,4-dienoyl-CoA reductase pathway. 4. From these results it is concluded that peroxisomes have the enzymatic apparatus necessary for the degradation of unsaturated fatty acids.