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C Benasco

Publications and source records attributed to C Benasco.

34 records · Page 2Linked to original sources
PubMed1987

Human chorionic gonadotropin in colorectal carcinoma. An immunohistochemical study.

To assess the biological significance of human chorionic gonadotropin (HCG) detection in large bowel carcinomas, we have studied immunohistochemically 50 colorectal carcinomas, 20 adenomas, 8 ulcerative colitis, and 10 normal colonic mucosae. The HCG-immunoreactive cells were found in 26 carcinomas (52%). Positivity was not detected in any normal mucosa or benign lesions. Cells containing HCG predominated in mucinous (80%) and poorly differentiated carcinomas (92%). No trophoblastic differentiation could be demonstrated in any tumor. Human chorionic gonadotropin was detected more frequently in carcinomas invading the entire bowel wall (67%) than in those confined to the submucosa or muscularis propria (30%). Fifteen of 19 cases (79%) with lymph node and/or hepatic metastases had HCG in the primary tumor, whereas only 9 of 23 cases (32%) without metastases showed HCG immunoreactivity. The eight patients with hepatic metastases had HCG in the primary tumor. Thus, the immunohistochemical detection of HCG in colorectal carcinomas may be a biological marker of prognostic significance.

Carcinoma↗
PubMed1985

Superficial esophageal carcinoma: a report of 12 cases.

Twelve cases of superficial carcinoma of the esophagus, representing 4.9% of patients with carcinoma of the esophagus, were evaluated. All the patients were male smokers who drank alcohol excessively. The main clinical features were dysphagia, asthenia, anorexia, and weight loss. Most of the lesions were elevated and all endoscopic biopsies were positive for cancer. Half of the cases showed invasion of the submucosa; the remainder involved mucosa only. Ten patients are alive and free of metastatic disease.

Aged↗
PubMed1983

Primary liposarcoma of the right ventricle and pulmonary artery: surgical excision and replacement of the pulmonic valve by a Björk-Shiley tilting disc valve.

A case of primary liposarcoma of the right ventricle and pulmonary artery is presented. The clinical picture, diagnostic studies, operative treatment and postoperative evolution are commented upon. Attention is drawn to the fact that this is the third case of liposarcoma of the heart to be operated upon, and the first needing pulmonary valve replacement. The literature related to this exceedingly rare primary neoplasm of the heart is reviewed.

Female↗
PubMedDate not supplied

Ferritin immunohistochemical localization in normal and neoplastic colonic mucosa.

High levels of ferritin have been detected in serum and tumoral extracts of gastrointestinal neoplasms. However, its histological localization is not well known. An immunoperoxidase technique (PAP) was used for detecting ferritin in 30 colorectal carcinomas, 20 polyps and 8 cases of non-neoplastic mucosae. Ferritin staining was detected in stromal cells (98%) much more than in epithelial cells (21%). Connective cells were positive in 5 cases of normal mucosae (62%), 19 polyps (95%) and all carcinomas (100%). The number of positive cells gradually rose from normal mucosa to carcinoma with an intermediate score in adenomas. However, no relation could be found between the stromal ferritin score and dysplasia in polyps. Likewise, no relation was found between the stromal ferritin score and the differentiation grade, invasion or metastases in carcinomas. The positive epithelial pattern seen in 12 cases (21%) suggests non-specific staining due to passive diffusion from the stroma. Thus, these immunohistochemical findings suggest that in colonic neoplasms, ferritin could be a tumor marker produced mainly by stromal cell reaction more than by the epithelial cells.

Adenoma↗
PubMedDate not supplied

Plant thorn synovitis.

A boy with an inflammatory monoarthritis due to penetration of the joint by palm thorn is presented. The clinical presentation was that of an acute synovitis of 2 months' duration, that improved quickly after arthroscopy for biopsy, and articular washout. Microscopic examination of the biopsy showed a granulomatous synovitis with vegetable tissue identified as a palm thorn.

Child↗